دورية أكاديمية
Size Dependence of Gold Nanorods for Efficient and Rapid Photothermal Therapy
| العنوان: | Size Dependence of Gold Nanorods for Efficient and Rapid Photothermal Therapy |
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| المؤلفون: | Wei Zhou, Yanhua Yao, Hailing Qin, Xiaobo Xing, Zongbao Li, Min Ouyang, Haihua Fan |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 4, p 2018 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | size-dependent effects, gold nanorod, surface plasmon resonance, photothermal, cancer, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | In recent years, gold nanomaterials have become a hot topic in photothermal tumor therapy due to their unique surface plasmon resonance characteristics. The effectiveness of photothermal therapy is highly dependent on the shape and size of gold nanoparticles. In this work, we investigate the photothermal therapeutic effects of four different sizes of gold nanorods (GNRs). The results show that the uptake of short GNRs with aspect ratios 3.3–3.5 by cells is higher than that of GNRs with aspect ratios 4–5.5. Using a laser with single pulse energy as low as 28 pJ laser for 20 s can induce the death of liver cancer cells co-cultured with short GNRs. Long GNRs required twice the energy to achieve the same therapeutic effect. The dual-temperature model is used to simulate the photothermal response of intracellular clusters irradiated by a laser. It is found that small GNRs are easier to compact because of their morphological characteristics, and the electromagnetic coupling between GNRs is better, which increases the internal field enhancement, resulting in higher local temperature. Compared with a single GNR, GNR clusters are less dependent on polarization and wavelength, which is more conducive to the flexible selection of excitation laser sources. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/25/4/2018Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms25042018 |
| الوصول الحر: | https://doaj.org/article/b93d2bc82ead44428c9c8d30869035a6Test |
| رقم الانضمام: | edsdoj.b93d2bc82ead44428c9c8d30869035a6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25042018 |