دورية أكاديمية
Microvascular vasodilator properties of the angiotensin II type 2 receptor in a mouse model of type 1 diabetes
| العنوان: | Microvascular vasodilator properties of the angiotensin II type 2 receptor in a mouse model of type 1 diabetes |
|---|---|
| المؤلفون: | Begorre, Marc-Antoine, Dib, Abdallah, Habchi, Khalil, Guihot, Anne-Laure, Bourreau, Jennifer, Vessieres, Emilie, Blondeau, Bertrand, Loufrani, Laurent, Chabbert, Marie, Henrion, Daniel, Fassot, Céline |
| المصدر: | Scientific Reports ; volume 7, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Multidisciplinary |
| الوصف: | Diabetes Mellitus is associated with severe cardiovascular disorders involving the renin-angiotensin system, mainly through activation of the angiotensin II type 1 receptor (AT1R). Although the type 2 receptor (AT2R) opposes the effects of AT1R, with vasodilator and anti-trophic properties, its role in diabetes is debatable. Thus we investigated AT2R-mediated dilatation in a model of type 1 diabetes induced by streptozotocin in 5-month-old male mice lacking AT2R (AT2R −/y ). Glucose tolerance was reduced and markers of inflammation and oxidative stress (cyclooxygenase-2, gp91phox p22phox and p67phox) were increased in AT2R −/y mice compared to wild-type (WT) animals. Streptozotocin-induced hyperglycaemia was higher in AT2R −/y than in WT mice. Arterial gp91phox and MnSOD expression levels in addition to blood 8-isoprostane and creatinine were further increased in diabetic AT2R −/y mice compared to diabetic WT mice. AT2R-dependent dilatation in both isolated mesenteric resistance arteries and perfused kidneys was greater in diabetic mice than in non-diabetic animals. Thus, in type 1 diabetes, AT2R may reduce glycaemia and display anti-oxidant and/or anti-inflammatory properties in association with greater vasodilatation in mesenteric arteries and in the renal vasculature, a major target of diabetes. Therefore AT2R might represent a new therapeutic target in diabetes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/srep45625 |
| الإتاحة: | https://doi.org/10.1038/srep45625Test https://www.nature.com/articles/srep45625.pdfTest https://www.nature.com/articles/srep45625Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.7BF21A36 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/srep45625 |
|---|