المؤلفون: Jinze Li, Maria M. Disotuar, Nai-Pin Lin, Jake A. Smith, Danny Hung-Chieh Chou, Steve L. Alam

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2719-2725 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Alb, albumin, Insulin degludec, pAkt, phosphorylated protein kinase B, Boc, tert-butyloxycarbonyl, medicine.medical_treatment, Lysine, DMSO, dimethyl sulfoxide, EDT, 1,2-ethanedithiol, 0302 clinical medicine, Diabetes mellitus, HATU, 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, NBD-X, 6-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoic acid, t-Bu, tert-butyl, General Pharmacology, Toxicology and Pharmaceutics, HTRF, homogeneous time resolved fluorescence, Mtt, 4-methyltrityl, Insulin detemir, Long-acting insulin, 0303 health sciences, Chemistry, Albumin-binding peptide SA21, i.p., intraperitoneal, Therapeutic Insulin, DCM, dichloromethane, Biochemistry, HPLC, high performance liquid chromatography, 030220 oncology & carcinogenesis, Sortase A, DMF, dimethylformamide, Fmoc, 9-fluorenylmethoxycarbonyl, medicine.drug, DOI, desoctapeptide (B23−30) insulin, Short Communication, RM1-950, DMEM, Dulbecco's Modified Eagle Medium, STZ, streptozotocin, TIS, triisoproylsilane, 03 medical and health sciences, FBS, fetal bovine serum, Insulin synthesis, medicine, ITT, insulin tolerance test, 030304 developmental biology, Insulin, THF, triflouroacetic acid, HBTU, O-(benxontriazol-1-yl)-1,1,3,3-tetramethyluronium, Sortase A (SrtA) ligation, medicine.disease, IR-B, human insulin receptor isoform B, LC‒MS, liquid chromatography mass spectrometry, DIEA, N,N-diisopropylethylamine, Therapeutics. Pharmacology, Ligation, SrtA, sortase A

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1984559319e185f56741a54626eb56Test
http://www.sciencedirect.com/science/article/pii/S2211383520308017Test

المؤلفون: Wenfu Tan, Huaqian Ding, Xiaohua Liu, Chunyong Ding, Juan Wang, Yalei Li, Ao Zhang, Yu Zhang, Hongchun Liu, Wenjing Huang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 488-504 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: SAR, structure−activity relationship, Hedgehog signaling pathway, BRD4, p.o., per os, medicine.medical_treatment, WNT, wingless, PK, pharmacokinetic, Targeted therapy, BRD4, bromodomain-containing protein 4, 03 medical and health sciences, 0302 clinical medicine, medicine, General Pharmacology, Toxicology and Pharmaceutics, BET, bromo and extra C-terminal bromodomain proteins, Hedgehog, BCC, basal cell carcinoma, 030304 developmental biology, Medulloblastoma, 0303 health sciences, MB, medulloblastoma, TGI, tumor growth inhibition, Oncogene, SHH, Sonic hedgehog, Chemistry, lcsh:RM1-950, medicine.disease, HH, hedgehog, Bromodomain, lcsh:Therapeutics. Pharmacology, Drug resistance, 030220 oncology & carcinogenesis, PTCH, patched, Cancer research, Original Article, i.v., intravenous injection, Smoothened, HTRF, homogeneous time-resolved fluorescence, hERG, human ether-a-go-go-related gene, SMO, smoothened, GLI

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301cde2b3eb755a22e93dd5c8eb925b1Test
https://doi.org/10.1016/j.apsb.2020.07.007Test

المؤلفون: Jianhong Ma, John R. White, Qi Liu

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: C3a desArg, CP, classical pathway, IgG, immunoglobulin G, Biochemistry, Classical complement pathway, MSD, ADCC, antibody-dependent cell-mediated cytotoxicity, Humans, ADCP, antibody-dependent cellular phagocytosis, mAb, monoclonal antibody, C3, CDC, complement-dependent cytotoxicity, Molecular Biology, Complement C1q, Complement Activation, Serum amyloid P component, classical complement pathway, Complement component 3, biology, Chemistry, FRET, fluorescence resonance energy transfer technology, Dezamizumab, Antibodies, Monoclonal, Cell Biology, Complement System Proteins, Surface Plasmon Resonance, MSD, meso scale discovery, Complement-dependent cytotoxicity, Complement system, LP, lectin pathway, Serum Amyloid P-Component, Lectin pathway, complement method, Immunoglobulin G, biology.protein, MAC, membrane attack complex, RS, reference standard, SAP, serum amyloid P, Complement membrane attack complex, SAP, HTRF, HTRF, homogeneous time-resolved fluorescence, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f933513331869a4d84c72fbc9ba7fdTest
http://europepmc.org/articles/PMC8463879Test

المؤلفون: Julie A. Pigza, Jared D. Hume, Jacques J. Kessl, Matthew Garrett Donahue, Jian Sun, Krunal Patel

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Integrase inhibitor, HIV Integrase, Virus Replication, Biochemistry, HIV-1, human immunodeficiency virus type 1, quinoline, HTRF, homogeneous time resolved fluorescence, human immunodeficiency virus, biology, Chemistry, CTD, C-terminal domain, DMSAO, dimethyl sulfoxide, Chromatin, Integrase, Cell biology, Quinolines, Intercellular Signaling Peptides and Proteins, CCD, catalytic core domain, I N, integrase, Research Article, Protein Binding, drug design, Virus Integration, Protein subunit, Allosteric regulation, ALLINI, allosteric IN inhibitors, Antiviral Agents, oligomerization, Protein–protein interaction, antiviral agent, 03 medical and health sciences, Allosteric Regulation, Humans, NTD, N-terminal domain, HIV Integrase Inhibitors, Binding site, Molecular Biology, RNP, ribonucleoprotein complex, 030102 biochemistry & molecular biology, Cell Biology, protein–protein interaction, HEK293 Cells, 030104 developmental biology, vDNA, viral cDNA, Viral replication, HIV-1, biology.protein, ALLINI, integrase, Protein Multimerization

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812afed44ebca78da55c911ffeaba508Test
https://doi.org/10.1016/j.jbc.2021.100363Test

المؤلفون: Jordan M. Mattheisen, Amanda R. Moore, Yu Chen, Ping Chi, Manija A. Kazmi, Tyler D. Hitchman, Mizuho Horioka, Thomas P. Sakmar, Emilie Ceraudo, Thomas Huber

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Uveal Neoplasms, 0301 basic medicine, Receptors, Vasopressin, Glutamine, MV, missense variant, Mutant, HTRF, homogeneous time-resolved fluorescence immunoassay, UVM, uveal melanoma, Biochemistry, Malignant transformation, CysLTR2, Receptor, Melanoma, β-arrestins, biased signaling, CA, constitutive activity, BRET, bioluminescent resonance energy transfer, LTD4, leukotriene D4, beta-Arrestin 2, CAM, constitutively active mutant, Cell biology, Gene Expression Regulation, Neoplastic, EPAC, exchange protein activated by cAMP, LiCl, lithium chloride, uveal melanoma, Signal transduction, signaling, Protein Binding, Signal Transduction, Research Article, PLCβ, phospholipase C-β, Recombinant Fusion Proteins, Green Fluorescent Proteins, V2(A)6, hexa-alanine variant, Biology, Models, Biological, RLuc3, Renilla Luciferase, DPBS, Dulbecco’s PBS, 03 medical and health sciences, FBS, fetal bovine serum, Downregulation and upregulation, Arrestin, Humans, BRET2, bioluminescent resonance energy transfer 2, constitutive activity, Molecular Biology, G protein-coupled receptor, Receptors, Leukotriene, CysLTR2, cysteinyl-leukotriene receptor 2, 030102 biochemistry & molecular biology, Lysine, G protein, Cell Biology, CI, confidence interval, Kinetics, HEK293 Cells, 030104 developmental biology, Cysteinyl leukotriene receptor 2, Amino Acid Substitution, G protein–coupled receptor, Mutation, GTP-Binding Protein alpha Subunits, Gq-G11, GPCR, G protein–coupled receptor, IP1, d-myo-inositol-1-phosphate, BSA, bovine serum albumin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5ec74a731e85fd58a86e6fd59224fdTest
https://doi.org/10.1074/jbc.ra120.015352Test

المؤلفون: Evi Kostenis, Nicole Merten, Max Crüsemann, Julian Patt, Nina Heycke, Uli Rick, Eva Marie Pfeil, Gabriele M. König, Funda Eryilmaz, Stefan Kehraus, Jan H. Voss, Xavier Deupi, Christa E. Müller, Asuka Inoue, Judith Alenfelder

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, loss-of-function mutagenesis, Biochemistry, G protein inhibitor, Adenylyl cyclase, chemistry.chemical_compound, FR900359, label-free biosensor, Arg60, arginine 60, SRE, serum response element, Depsipeptides, Heterotrimeric G protein, HBSS, Hanks' buffered salt solution, RTK, receptor tyrosine kinases, AC, adenylyl cyclase, HTRF, homogeneous time resolved fluorescence, biology, G proteins, guanine nucleotide-binding proteins, DMR, dynamic mass redistribution, Heterotrimeric GTP-Binding Proteins, GTP-Binding Protein alpha Subunits, Cell biology, Gq alpha subunit, PTX, pertussis toxin, FR, FR900359, Signal transduction, Signal Transduction, Research Article, heterotrimeric G protein, CCh, carbachol, G protein, UBO-QIC, YM-254890, YM, YM-254890, Peptides, Cyclic, GEF, guanine nucleotide exchange factor, 03 medical and health sciences, PLC, phospholipase C, PDB, Protein Data Bank, Humans, Gαq, dynamic mass redistribution (DMR), Molecular Biology, G protein-coupled receptor, IP1, inositol monophosphate, 030102 biochemistry & molecular biology, Phospholipase C, HEK 293 cells, Cell Biology, HEK293 Cells, 030104 developmental biology, chemistry, biology.protein, GTP-Binding Protein alpha Subunits, Gq-G11, GPCR, G protein–coupled receptor, FCS, fetal calf serum, HA, hemagglutinin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad14382365f90e4057dbc24db130542Test
https://doi.org/10.1016/j.jbc.2021.100472Test