المؤلفون: Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Target, ONRs, orphan nuclear receptors, Parkinson's disease, Small-molecule compound, MPP+, 1-methyl-4-phenylpyridinium, Autolysosome, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, GBA, glucocerebrosidase β acid, Review, MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Disease, mTORC1, mTOR, the mammalian target of rapamycin, PD, Parkinson's disease, 0302 clinical medicine, CL, clearance rate, DAT, dopamine transporter, HDAC6, histone deacetylase 6, PD therapy, A2A, adenosine 2A, MYCBP2, MYC-binding protein 2, TFEB, transcription factor EB, AUTAC, autophagy targeting chimera, General Pharmacology, Toxicology and Pharmaceutics, SAS, solvent accessible surface, 0303 health sciences, α-syn, α-synuclein, ALP, autophagy-lysosomal pathway, AADC, aromatic amino acid decarboxylase, DJ-1, Parkinson protein 7, PI3K, phosphatidylinositol 3-kinase, COMT, catechol-O-methyltransferase, LUHMES, lund human mesencephalic, LRRK2, CMA, chaperone-mediated autophagy, KI, knockin, 030220 oncology & carcinogenesis, LRS, leucyl-tRNA synthetase, BBB, blood−brain barrier, SN, substantia nigra, IMPase, inositol monophosphatase, IPPase, inositol polyphosphate 1-phosphatase, HSPA8, heat shock 70 kDa protein 8, MAO-B, monoamine oxidase B, PREP, prolyl oligopeptidase, Parkinson's disease (PD), DR, dopamine receptor, PDE4, phosphodiesterase 4, AMPK, 5ʹAMP-activated protein kinase, 5-HT2C, serotonin 2C, SNCA, α-synuclein gene, TSC2, tuberous sclerosis complex 2, RM1-950, LIMP-2, lysosomal integrated membrane protein-2, CNS, central nervous system, 5-HT2A, Serotonin 2A, ER, endoplasmic reticulum, ATG, autophagy related protein, 03 medical and health sciences, PLC, phospholipase C, ROS, reactive oxygen species, ERRα, estrogen-related receptor alpha, SAR, structure–activity relationship, ULK1, UNC-51-like kinase 1, medicine, Autophagy, NMDA, N-methyl-d-aspartic acid, mAChR, muscarinic acetylcholine receptor, GWAS, genome-wide association study, LAMP2A, lysosome-associated membrane protein 2 A, Lamp2a, type 2A lysosomal-associated membrane protein, 030304 developmental biology, Parkin, parkin RBR E3 ubiquitin−protein ligase, PINK1, PTEN-induced kinase 1, ATTEC, autophagosome-tethering compound, ATP13A2, ATPase cation transporting 13A2, business.industry, ULK1, medicine.disease, LC3, light chain 3, PI3P, phosphatidylinositol 3-phosphate, SYT11, synaptotagmin 11, AUC, the area under the curve, UPS, ubiquitin−proteasome system, TFEB, DA, dopamine, Therapeutics. Pharmacology, business, BAF, bafilomycinA1, HSC70, heat shock cognate 71 kDa protein, Neuroscience, 3-MA, 3-methyladenine, F, oral bioavailability, LRRK2, leucine-rich repeat sequence kinase 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12dab43aca56bfd6a912c2aa71297ffTest
http://www.sciencedirect.com/science/article/pii/S2211383521000642Test

المؤلفون: Holly Hilton, Michael E. Burczynski, Saumya Pant

المصدر: Biochemical Pharmacology

مصطلحات موضوعية: AQP1, aquaporin 1, miRNA or miR, micro RNA, SNAREs, SNAP (soluble NSF attachment protein) receptor, HLA-DR, MHC class II cell surface receptor, Cell, Exosomes, Biochemistry, APCs, antigen presenting cells, MIF, macrophage migration inhibitory factor, iDex, immature D cell derived exosomes, I/R, ischemia reperfusion, DNA, deoxyribonucleic acid, DC, dendritic cell, GTPase, guanosine triphosphatase, TSG101, Rab GTPases, “Ras-related in brain” GTPase, Secretome, TGF, tumor growth factor, TNF, tumor necrosis factor, PSA, prostate-specific antigen, CXCL5, C-X-C motif chemokine 5, VEGF, vascular endothelial growth factor, mRNA, messenger RNA, MVB, multivesicular bodies, HIV, human immunodeficiency virus, medicine.anatomical_structure, AP2, clathrin adaptor protein, ATPase, adenosine triphosphatase, ESCRT, endosomal sorting complex required for transport, PCA3, prostate CAncer gene 3, Microvesicles, TSPAN, tetraspanin, Cell type, Microenvironment, WT1, Wilms tumor protein, PI3K, phosphatidyl inositol-3-kinase, CD, cluster of differentiation, Antigen presentation, KRAS, protein involved in cell cycle regulation, TSG101, tumor susceptibility gene 101, AKI, acute kidney injury, Biology, Exosome, Article, ESCRT, Hsc70, heat shock cognate 71 kDa protein, EBV, Epstein Barr virus, ILV, intraluminal vesicles, ELISA, enzyme linked immunosorbent assay, medicine, Humans, MHC, major histocompatibility complex, HLA-DR, MHC class II receptor encoded by human leukocyte antigen complex, SARS, severe acute respiratory syndrome, CCR1, chemokine (C–C motif) receptor 1, VLP, virion-like particles, Pharmacology, Fluidome, Cell growth, RT-PCR, reverse transcriptase PCR, CKD, chronic kidney disease, Membrane Proteins, ICAM1, inter-cellular adhesion molecule 1, FACS, fluorescence activated cell sorting, IL, interleukin, EGFR, epidermal growth factor receptor, Gene Expression Regulation, EMMPRIN, extracellular matrix metalloproteinase inducer, Cancer research, NKCC2, sodium–potassium–chloride co-transporter, LFA1, lymphocyte function-associated antigen 1, ATF3, cyclic AMP-dependent transcription factor, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817acf512d031baa3fedb41dd23f51abTest
https://doi.org/10.1016/j.bcp.2011.12.037Test