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المؤلفون: Yi-Chao Zheng, Yue-Jiao Liu, Li-Ying Ma, Yinghua You, Haojie Wang, Hong-Min Liu, Yang Feifei, Chao-Ya Ma
المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 9, Pp 1658-1668 (2020)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: MOE, molecular operating environment, animal structures, 1,2,3-Triazole, Pyrimidine, Stereochemistry, EMT, epithelial to mesenchymal transition, TCP, tranylcypromine, IC50, half maximal inhibitory concentration, LSD1, histone lysine specific demethylase 1, VDW, van der Waals, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, FBS, fetal bovine serum, PAINS, pan assay interference compounds, Moiety, General Pharmacology, Toxicology and Pharmaceutics, PDB, the Protein Data Bank, AML, acute myeloid leukemia, ANOVA, analysis of variance, Flavin adenine dinucleotide (FAD), 030304 developmental biology, Flavin adenine dinucleotide, 0303 health sciences, ESI, electrospray ionization, biology, LSD1 inhibitors, lcsh:RM1-950, RLU, relative light units, Cell migration, FAD, flavin adenine dinucleotide, Anticancer, lcsh:Therapeutics. Pharmacology, Histone, HRMS, high resolution mass spectra, chemistry, Docking (molecular), 030220 oncology & carcinogenesis, FAD binding, biology.protein, Original Article, SARs, structure–activity relationship studies, Gastric cancer
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8ed8f9fce726a289b0ae8847cad43dTest
https://doi.org/10.1016/j.apsb.2020.02.006Test -
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المؤلفون: Axel Knebel, Lorna Plater, Christoph H. Emmerich, Sam Strickson, Natalia Shpiro, Philip Cohen, David G. Campbell, Maria Stella Ritorto
المصدر: Biochemical Journal
مصطلحات موضوعية: Lipopolysaccharides, Ubiquitin-conjugating enzyme, Biochemistry, DMEM, Dulbecco’s modified Eagle’s medium, Mice, linear ubiquitin assembly complex (LUBAC), K63-pUb, Lys63-linked polyubiquitin, NF-KappaB Inhibitor alpha, Ubiquitin, MS/MS, tandem MS, nuclear factor κB (NF-κB), pUb, polyubiquitin, TRAF, tumour-necrosis-factor-receptor-associated factor, Sulfones, RBR, RING-between-RING, TAB, TAK1-binding protein, IKK, IκB kinase, IκB, inhibitor of NF-κB, GFP, green fluorescent protein, HOIP, haem-oxidized IRP2 ligase-1-interacting protein, NEMO, NF-κB essential modifier, K48-pUb, Lys48-linked polyubiquitin, biology, LUBAC, linear ubiquitin assembly complex, Kinase, NEDD8, neural-precursor-cell-expressed developmentally down-regulated 8, Ubiquitin ligase, HRMS, high-resolution mass spectra, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, TBK1, tumour-necrosis-factor-receptor-associated factor-associated NF-κB activator-binding kinase 1, JNK, c-Jun N-terminal kinase, LPS, lipopolysaccharide, Phosphorylation, I-kappa B Proteins, ubiquitin conjugating 13 (Ubc13), NF-κB, nuclear factor κB, DLBCL, diffuse large B-cell lymphoma, PAMP, pathogen-associated molecular pattern, Signal Transduction, Research Article, Proteasome Endopeptidase Complex, Molecular Sequence Data, lymphoma, MALDI–TOF, matrix-assisted laser-desorption ionization–time-of-flight, ERK, extracellular-signal-regulated kinase, HEK, human embryonic kidney, Ubc, ubiquitin conjugating, Cell Line, Tumor, Nitriles, MyD88, myeloid differentiation factor 88, Animals, Humans, Amino Acid Sequence, Molecular Biology, HIF1α, hypoxia-inducible factor 1α, IL-1R, IL-1 receptor, HTLV-1, human T-cell lymphotropic virus 1, Macrophages, HEK 293 cells, Ubiquitination, NF-kappa B p50 Subunit, Receptors, Interleukin-1, myeloid differentiation factor 88 (MyD88), TAK1, transforming growth factor β-activated kinase 1, Cell Biology, Hypoxia-Inducible Factor 1, alpha Subunit, Molecular biology, IL, interleukin, UBE, ubiquitin-activating enzyme, IκBα, proteasome, Gene Expression Regulation, Proteasome, IRAK, IL-receptor-associated kinase, Myeloid Differentiation Factor 88, Ubiquitin-Conjugating Enzymes, biology.protein, MAPK, mitogen-activated protein kinase, Interleukin-1, DAPI, 4′,6-diamidino-2-phenylindole
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af6008194e741619655a2e05fd75147Test
https://doi.org/10.1042/bj20121651Test -
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المؤلفون: Lawrence H. Pinto, Santiago Vázquez, Lieve Naesens, María D. Duque, Mathy Froeyen, Chunlong Ma, Eva Torres, Pelayo Camps, Evelien Vanderlinden
المصدر: Antiviral Research
مصطلحات موضوعية: wt, wild-type, Stereochemistry, viruses, Mutant, Hemagglutinin (influenza), Hemagglutinin Glycoproteins, Influenza Virus, MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, medicine.disease_cause, Antiviral Agents, Virus, Article, Structure-Activity Relationship, Influenza A Virus, H1N1 Subtype, Virology, Influenza, Human, Influenza A virus, medicine, Amantadine, Humans, Polycyclic Compounds, Amines, Hemagglutinin, M2 protein, Cytopathic effect, Pharmacology, biology, Molecular Structure, Chemistry, Influenza A Virus, H3N2 Subtype, TEV, two-electrode voltage clamps, Wild type, virus diseases, MDCK, Madin–Darby canine kidney, NMDA, N-methyl-d-aspartate, Polycyclic amines, M2 proton channel, CPE, cytopathic effect, HRMS, high resolution mass spectra, Amt, amantadine, biology.protein, Amine gas treating, HA, hemagglutinin, TM, transmembrane
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a47734c2752df8a5d424ccb9b16e8cTest
https://pubmed.ncbi.nlm.nih.gov/23800838Test