Risk associations between HLA-DPB1 T-cell epitope matching and outcome of unrelated hematopoietic cell transplantation are independent of HLA-DPA1
| العنوان: | Risk associations between HLA-DPB1 T-cell epitope matching and outcome of unrelated hematopoietic cell transplantation are independent of HLA-DPA1 |
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| المؤلفون: | Vijay Reddy, Fabio Ciceri, Susana R. Marino, Bronwen E. Shaw, David B. Miklos, Gregory A. Hale, Jason Dehn, Marilyn S. Pollack, Edmund K. Waller, P.L. McCarthy, Stephen R. Spellman, Lee Ann Baxter-Lowe, Martin B. A. Heemskerk, Minoo Battiwalla, Marcelo Fernandez-Vina, Machteld Oudshoorn, Stephanie J. Lee, James Gajewski, Katharina Fleischhauer, David Senitzer, Michael Haagenson, Tao Wang |
| المساهمون: | Fleischhauer, K, Fernandez Vina, Ma, Wang, T, Haagenson, M, Battiwalla, M, Baxter Lowe, La, Ciceri, Fabio, Dehn, J, Gajewski, J, Hale, Ga, Heemskerk, Mba, Marino, Sr, Mccarthy, Pl, Miklos, D, Oudshoorn, M, Pollack, M, Reddy, V, Senitzer, D, Shaw, Be, Waller, Ek, Lee, Sj, Spellman, Sr |
| المصدر: | Bone marrow transplantation |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Risk, HLA-DPB1 T cell epitope matching, Linkage disequilibrium, Transplantation Conditioning, Adolescent, medicine.medical_treatment, Medizin, Epitopes, T-Lymphocyte, Hematopoietic stem cell transplantation, Human leukocyte antigen, HLA-DP alpha-Chains, Article, Epitope, Cohort Studies, transplant related mortality, Young Adult, Unrelated HCT, HLA-DPA1, Humans, Medicine, Allele, Child, HLA-DP beta-Chains, relapse, Non-permissive mismatch, Transplantation, HLA-DPB1, business.industry, Hematopoietic Stem Cell Transplantation, Infant, Hematology, Middle Aged, medicine.disease, 3. Good health, Graft-versus-host disease, Child, Preschool, Immunology, Female, Unrelated Donors, business, Epitope Mapping |
| الوصف: | HLA-DP antigens are beta-alpha heterodimers encoded by polymorphic HLA-DPB1 and -DPA1 alleles, respectively, in strong linkage disequilibrium (LD) with each other. Non-permissive unrelated donor (UD)-recipient HLA-DPB1 mismatches across three different T-cell epitope (TCE) groups are associated with increased mortality after hematopoietic SCT (HCT), but the role of HLA-DPA1 is unclear. We studied 1281 onco-hematologic patients after 10/10 HLA-matched UD-HCT facilitated by the National Marrow Donor Program. Non-permissive mismatches defined solely by HLA-DPB1 TCE groups were associated with significantly higher risks of TRM compared to permissive mismatches (hazard ratio (HR) 1.30, confidence interval (CI) 1.06-1.53; P = 0.009) or allele matches. Moreover, non-permissive HLA-DPB1 TCE group mismatches in the graft versus host (GvH) direction significantly decreased the risk of relapse compared to permissive mismatches (HR 0.55, CI 0.37-0.80; P = 0.002) or allele matches. Splitting each group into HLA-DPA1*02:01 positive or negative, in frequent LD with HLA-DPB1 alleles from two of the three TCE groups, or into HLA-DPA1 matched or mismatched, did not significantly alter the observed risk associations. Our findings suggest that the effects of clinically non-permissive HLA-DPB1 TCE group mismatches are independent of HLA-DPA1, and that selection of donors with non-permissive DPB1 TCE mismatches in GvH direction might provide some protection from disease recurrence. OI Heemskerk, Martin/0000-0002-9432-7623 |
| تدمد: | 1476-5365 0268-3369 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a57c47296b1f6fdcc96974b9195662cTest https://doi.org/10.1038/bmt.2014.122Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4a57c47296b1f6fdcc96974b9195662c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765365 02683369 |
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