المؤلفون: Niamh C. Williams, Dylan G. Ryan, Ana S.H. Costa, Evanna L. Mills, Mark P. Jedrychowski, Suzanne M. Cloonan, Christian Frezza, Luke A. O'Neill

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Lipopolysaccharides, αKG, α-ketoglutarate, 2HGDH, 2-hydroxyglutarate dehydrogenase, immunometabolism, OXPHOS, oxidative phosphorylation, IDH, isocitrate dehydrogenase, L-2-hydroxyglutarate, macrophage, Biochemistry, Glutarates, 03 medical and health sciences, IL-1β, interleukin 1β, 0302 clinical medicine, TET, ten-eleven translocation DNA hydroxylase, Humans, 2HG, 2-hydroxyglutarate, Molecular Biology, KDM, Jmjj-domain containing histone lysine demethylases, 030304 developmental biology, 0303 health sciences, LDH, lactate dehydrogenase, Macrophages, PHD, HIF prolyl hydroxylase, Cell Biology, MDH, malate dehydrogenase, Macrophage Activation, glycolysis, Hypoxia-Inducible Factor 1, alpha Subunit, interleukin 1β (IL-1β), hypoxia-inducible factor (HIF), BMDM, bone-marrow-derived macrophages, mtROS, mitochondrial reactive oxygen species, HEK293 Cells, inflammation, 030220 oncology & carcinogenesis, SDH, succinate dehydrogenase, HIF-1α, hypoxia-inducible factor 1α, LPS, lipopolysaccharide, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349c95bf1633c1057ab765daa0319a9aTest
https://pubmed.ncbi.nlm.nih.gov/34929172Test

المؤلفون: Weilong Zhong, Qiang Zhang, Kailiang Qiao, Lan Yang, Guang Yang, Jia-Huan Yang, Yanrong Liu, Yuan Qin, Huijuan Liu, Cheng Yang, Tao Sun, Denghui Zhai, Meng Li, Yuanhao Tang

المصدر: EBioMedicine

مصطلحات موضوعية: Hypoxic tumor microenvironment, 0301 basic medicine, Research paper, OXA, oxaliplatin, Drug resistance, Mice, chemistry.chemical_compound, 0302 clinical medicine, Glucosides, Cell Movement, Tumor Microenvironment, Hypoxia, media_common, DDP, cisplatin, Chemistry, Liver Neoplasms, Salidroside, General Medicine, ECM, extracellular matrix, 030220 oncology & carcinogenesis, HCC, hepatocellular carcinomas, medicine.symptom, EMT, epithelial–mesenchymal transition, Signal Transduction, medicine.drug, Drug, Epithelial-Mesenchymal Transition, Cell Survival, media_common.quotation_subject, PCNA, proliferating cell nuclear antigen, Sal, salidroside, HIF-1α, Antineoplastic Agents, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Phenols, In vivo, Cell Line, Tumor, parasitic diseases, medicine, Animals, Humans, Epithelial–mesenchymal transition, Cisplatin, Gene Expression Profiling, MDR, multi-drug resistance, MRP, multidrug resistance-associated protein, Computational Biology, CI, combination index, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, Xenograft Model Antitumor Assays, Oxaliplatin, Disease Models, Animal, 030104 developmental biology, Drug Resistance, Neoplasm, HIF-1α, hypoxia-inducible factor 1α, Cancer research

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145543069c6046cdd445435da8576d8cTest
https://doi.org/10.1016/j.ebiom.2018.10.069Test

المؤلفون: Xiaojuan, Zhang, Chuanchuan, He, Yun, Sun, Xiaoguang, Liu, Yan, Chen, Chen, Chen, Ruicong, Yan, Ting, Fan, Tan, Yang, Yao, Lu, Jun, Luo, Xiang, Ma, Guangya, Xiang

المصدر: Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Transportation, CTGF, connective tissue growth factor, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Nanoparticle, FBS, fetal bovine serum, DSPE-PEG2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000], NP, nanoparticle, P-gp, P-glycoprotein, Chemotherapy, MS, monostearin, Hypoxia, TEM, transmission electron microscopy, EPR, enhanced permeability and retention, HA, hyaluronic acid, Tumor, MCTS, multicellular tumor spheroids, HIF-1, TME, tumor microenvironment, OA, oleic acid, DOX, doxorubicin, HAase, hyaluronidase, ECM, extracellular matrix, PDT, photodynamic therapy, HIF-1α, hypoxia-inducible factor 1α, Original Article, CaO2, MnO2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::460386643ca1b16bac3281f4e9c23847Test
https://pubmed.ncbi.nlm.nih.gov/34900540Test

المؤلفون: Jonathan A. Cappel, Mark A. Cappel, David A. Wetter

المصدر: Mayo Clinic Proceedings

مصطلحات موضوعية: nsp, nonstructural protein, Erythema, STAT3, signal transducer and activator of transcription 3, ADAM17, a disintegrin and metalloproteinase 17, MxA, myxovirus resistance protein A, Plasmacytoid dendritic cell, Review, rash, 030204 cardiovascular system & hematology, infectious diseases, IFN-I, type I interferon, pDC, plasmacytoid dendritic cell, Pathogenesis, Renin-Angiotensin System, 0302 clinical medicine, PCR, polymerase chain reaction, RAAS, renin-angiotensin-aldosterone system, Interferon, Medicine, 030212 general & internal medicine, AT2R, angiotensin type 2 receptor, TMPRSS2, transmembrane protease serine 2, STAT1, signal transducer and activator of transcription 1, COVID-19, coronavirus disease 2019, ANGII, angiotensin II, Vasospasm, General Medicine, Chilblains, dermatology, S2, spike protein 2, Disease Susceptibility, medicine.symptom, JAK, Janus kinase, medicine.drug, medicine.medical_specialty, TLR7, toll-like receptor 7, ACE, angiotensin-converting enzyme, ANG1-7, angiotensin-(1-7), SARS-CoV, severe acute respiratory syndrome coronavirus, Treg, regulatory T cell, ACE2, angiotensin-converting enzyme 2, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Fingers, 03 medical and health sciences, Immune system, IFN-α, interferon α, Humans, IFN, interferon, SARS, NO, nitric oxide, TREX1, 3′ repair exonuclease 1, IFN-β, interferon β, business.industry, SARS-CoV-2, COVID-19, Toes, S1, spike protein 1, medicine.disease, Dermatology, Angiotensin II, Ig, immunoglobulin, ANG, angiotensin, IL, interleukin, TH17, helper T cell 17, Vasoconstriction, AT1R, angiotensin type 1 receptor, HIF-1α, hypoxia-inducible factor 1α, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5efab0d6fd00dce62f7a2bd4da04fabTest
http://europepmc.org/articles/PMC7826004Test

المؤلفون: Hisataka Sabe, Mei Horikawa, Yasuhito Onodera

المصدر: Translational Oncology
Translational Oncology, Vol 15, Iss 1, Pp 101258-(2022)

مصطلحات موضوعية: Cancer Research, PRKD2, Immunoprecipitation, PRKD2, protein kinase D2, LAMP-1, lysosomal-associated membrane protein 1, PIAS3, CA9, Extracellular, Transcriptional regulation, RC254-282, Original Research, Gene knockdown, Chemistry, PIAS3, protein inhibitor of activated STAT3, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, HIF1A, Protein kinase D2, Cell biology, ECM, extracellular matrix, ASAP1, Blot, Oncology, CAIX, carbonic anhydrase IX, AMAP1, A Multiple-domain Arf-GAP Protein 1, HIF-1α, hypoxia inducible factor 1α, Intracellular

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c57043e219f7342c5e82dd3bfaf6bfTest
http://hdl.handle.net/2115/84125Test

المؤلفون: Jing Li, Shuang Li, Chaohua Tang, Tengfei Zhan, Qingyu Zhao, Kai Zhang, Xiaoqing Guo, Junmin Zhang, Yunsheng Han

المصدر: Redox Biology
Redox Biology, Vol 36, Iss, Pp 101519-(2020)

مصطلحات موضوعية: ACAA2, 3-ketoacyl-CoA thiolase mitochondrial, Swine, IL1R1, IL-1β receptor, PLCG2, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, Biochemistry, 0302 clinical medicine, Selenium deficiency, ceRNA, competing endogenous RNA, GSH, glutathione, Glycolysis, ANPEP, aminopeptidase N, KLF15, krueppel-like factor 15, lcsh:QH301-705.5, GSSG, oxidized glutathione, SAM, S-adenosylmethionine, TG, triglycerides, PS, phosphatidylserine, Warburg effect, TGF-β, transfer growth factor β, Se-D, Se deficient, Sed-7p, sedoheptulose 7-phosphate, PDK4, pyruvate dehydrogenase kinase isozyme 4, PLPP3, phosphatidate phosphatase 3, PKLR, pyruvate kinase, lcsh:Medicine (General), Redox imbalance, PE, phosphatidylethanolamine, ICP-MS, inductively coupled plasma mass spectrometry, 03 medical and health sciences, Selenium, NADH, nicotinamide adenine dinucleotide, Se-A, Se adequate, CPT2, carnitine palmitoyltransferase 2, NF-κB, nuclear factor κ-light-chain-enhancer’ of activated B-cells, MDA, malondialdehyde, PGD, 6-phosphogluconate dehydrogenase, PAPSS2, bifunctional 3′-phosphoadenosine5′-phosphosulfate synthase 2, ISG15, ubiquitin-like protein ISG15, medicine.disease, IL, interleukin, Citric acid cycle, 030104 developmental biology, TKFC, dihydroxyacetone kinase, SELENO, selenoprotein, Diabetes Mellitus, Type 2, ACOX1, acyl-CoA oxidase 1, CAT, catalase, DGKZ, diacylglycerol kinase zeta, 030217 neurology & neurosurgery, 0301 basic medicine, ACSL5, long-chain-fatty-acid--CoA ligase 5-like, Clinical Biochemistry, FASN, fatty acid synthase, SEPHS2, selenophosphate synthetase 2, GPX, glutathione peroxidase, PG, phosphatidylglycerol, GST, glutathione S-transferase, GK, glycerol kinase, PC, phosphatidylcholine, TXNRD, thioredoxin reductase, TNF-α, tumor necrosis factor α, MSRB, methionine-R-sulfoxide, lcsh:R5-920, ncRNA, non-coding RNA, RIG-1, antiviral innate immune response receptor RIG-I, Chemistry, Metabolic reprogramming, TRX, thioredoxin, Liver, Ribu-5P, ribose-5-phosphate, GPAM, glycerol-3-phosphate acyltransferase 1, Oxidation-Reduction, TCA, tricarboxylic acid cycle, DG, diglycerides, Research Paper, SOD, super oxide dismutase, ATP, adenosine triphosphate, CL, cardiolipin, Mx1, interferon-induced GTP-binding protein Mx1, PPP, pentose phosphate pathway, Cysthi, l-Cystathionine, PI, phosphatidylinositol, Se, selenium, ROS, reactive oxygen species, IFIT, interferon-induced protein with tetratricopeptide repeats, medicine, Metabolome, Animals, Cer, ceramides, Inflammation, PCA, principal component analysis, 2-OG, Oxoglutaric acid, Catabolism, Organic Chemistry, SAH, S-adenosylhomocysteine, Lipid metabolism, NADPH, nicotinamide adenine dinucleotide phosphate, ADP, adenosine diphosphate, GLUD1, glutamate dehydrogenase 1, Glutamine, AMPK, AMP-activated protein kinase, lcsh:Biology (General), AMP, adenosine monophosphate, FA, fatty acids, CPT1A, carnitine O-palmitoyltransferase 1, HIF-1α, hypoxia-inducible factor 1α, Pig liver, CTH, cystathionase, GCLC, glutamate-cysteine ligase catalytic subunit

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c256895562836b68aac08f98cd61154aTest
http://europepmc.org/articles/PMC7287308Test

المؤلفون: Tomal Dattaroy, Santanu Dasgupta, Vinod Nagle, Jayanta Talukdar, Bhaskar Bhadra

المصدر: Biomedicine & Pharmacotherapy, Vol 132, Iss, Pp 110886-(2020)
Biomedicine & Pharmacotherapy

مصطلحات موضوعية: 0301 basic medicine, ARDS, Exacerbation, MSCs, mesenchymal stem cells, MPO, myeloperoxidase, Review, ICAM-1, intercellular adhesion molecule-1, Xanthophylls, Cytokine storm, M-CSF, macrophage colony-stimulating factor, PDGF, platelet-derived growth factor, Pathogenesis, 0302 clinical medicine, Risk Factors, IkB, inhibitor nuclear factor-kappa B, GSH, glutathione, TGF, transforming growth factor, NT, nitrotyrosine, TNF, tumor necrosis factor, LDH, lactate dehydrogenase, Acute respiratory distress syndrome, IL-1ra, interleukin-1 receptor antagonist, General Medicine, VEGF, vascular endothelial growth factor, CCL-3, chemokine (C-C motif) ligand 3, 030220 oncology & carcinogenesis, COX-2, cyclooxygenase-2, CRP, C-reactive protein, LPS, lipopolysaccharide, Cytokines, Tumor necrosis factor alpha, dsRNA, double stranded ribonucleic acid, Antioxidant, GM-CSF, granulocyte-macrophage colony-stimulating factor, MIP, macrophage inflammatory protein, ALT, alanine transaminase, HCFs, human cardiac fibroblasts, HDAC4, histone deacetylase 4, RM1-950, Lung injury, Antiviral Agents, stat, 03 medical and health sciences, Immune system, Fibrinolytic Agents, SOD, superoxide dismutase, medicine, PGE2, prostaglandin E2, Animals, Humans, ComputingMethodologies_COMPUTERGRAPHICS, Pharmacology, MDA, malondialdehyde, NO, nitric oxide, business.industry, PPARs, peroxisome proliferator-activated receptors, SARS-CoV-2, Astaxanthin, COVID-19, MCP, monocyte chemoattractant protein, medicine.disease, G-CSF, granulocyte colony-stimulating factor, COVID-19 Drug Treatment, 030104 developmental biology, Immunology, FOXO3, forkhead box O3 gene, HGF, hepatocyte growth factor, MMPs, matrix metalloproteinases, HIF-1α, hypoxia inducible factor 1α, Therapeutics. Pharmacology, AST, aminotransferase, Anti-inflammatory, business, MAPK, mitogen-activated protein kinase, LFA-1, leukocyte function antigen 1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd7bf3aa8d9fd5d6f23a47947a5470cTest
https://pubmed.ncbi.nlm.nih.gov/33113418Test

المؤلفون: Jiguang Ma, Qingyong Ma, Qinhong Xu, Weikun Qian, Liang Cheng, Bin Yan, Liang Han, Han Liu, Wei Li

المصدر: Computational and Structural Biotechnology Journal, Vol 16, Iss, Pp 479-487 (2018)
Computational and Structural Biotechnology Journal

مصطلحات موضوعية: 0301 basic medicine, lcsh:Biotechnology, Biophysics, HIF-1α, PSC, pancreatic stellate cells, STZ, streptozotocin, Biochemistry, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, In vivo, SOD, superoxide dismutase, lcsh:TP248.13-248.65, Pancreatic cancer, Diabetes mellitus, Genetics, medicine, Hypoxia, TEM, transmission electron microscopy, EGF, epidermal growth factor, business.industry, GDNF, glial cell line-derived neurotrophic factor, CCL2, chemical chemokine 2, Hypoxia (medical), medicine.disease, Streptozotocin, VEGF, vascular endothelial growth factor, Computer Science Applications, CoCl2, cobalt chloride, ECM, endothelial cells, extracellular matrix, 030104 developmental biology, medicine.anatomical_structure, Hyperglycemia, H2O2, hydrogen peroxide, 030220 oncology & carcinogenesis, HIF-1α, hypoxia-inducible factor 1α, Cancer research, Immunohistochemistry, PNI, perineural invasion, medicine.symptom, EMT, epithelial-mesenchymal transition, Pancreas, business, Research Article, Biotechnology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92efc4506fb8f4b87b9567b9a58e1dc1Test
https://doi.org/10.1016/j.csbj.2018.10.006Test

المؤلفون: Na Li, Yafang Wang, Tiffany Horng, Xin Zhang

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, mitochondrial metabolism, FADH2, flavin adenine dinucleotide hydride, OXPHOS, oxidative phosphorylation, GAPDH, glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase, PPAR, peroxisome proliferator-activated receptor, AST, aspartate aminotransferase, PGE2, Prostaglandin E2, Mitochondrion, SUCLG1, succinyl-CoA synthetase, medicine.disease_cause, Biochemistry, DNM1L, macrophage biology, UPR, unfolded protein response, AMP-activated protein kinase, oxidative stress, Citrate synthase, α-KG, α-ketoglutarate, NF-κB, nuclear factor kappa B, NLRP3, NOD-, LRR- and pyrin domain-containing 3, oxPAPC, 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine, GAD, glutamic acid decarboxylase, CIC, mitochondrial citrate carrier, biology, Mitochondria, Cell biology, SDH, succinate dehydrogenase, iNOS, inducible nitric oxide synthase, LPS, lipopolysaccharide, PARP, Poly (ADP-ribose) polymerase, TLR, Toll-like receptor, Mitochondrial DNA, NADH, adenine diphosphate hydride, ETC, electron transport chain, TCA, tricarboxylic acid, IDH, isocitrate dehydrogenase, mTOR, mammalian target of rapamycin, Oxidative phosphorylation, MAS, malate-aspartate shuttle, eIF5A, hypusination of translation factor eukaryotic initiation factor 5A, ER, endoplasmic reticulum, 03 medical and health sciences, ΔΨm, mitochondrial membrane potential, IRG1, Immune-Responsive Gene 1, KLF4, Krüppel-like factor 4, macrophage activation, PAMPs, pathogen-associated molecular patterns, mitochondrial dysfunction, Succinate receptor 1, medicine, Animals, Humans, DMF, Dimethyl fumarate, GSDMD, gasdermin D, IFNγ, interferon-γ, MDVs, mitochondria-derived vesicles, Molecular Biology, Drp1, dynamin-related protein 1, SIRT, Sirtuin, PHD, prolyl hydroxylases, NO, nitric oxide, ACLY, ATP citrate lyase, 030102 biochemistry & molecular biology, Macrophages, JBC Reviews, Cell Biology, SUCNR1, succinate receptor 1, HMGB1, high mobility group box 1, mtROS, mitochondrial reactive oxygen species, AMPK, AMP-activated protein kinase, 030104 developmental biology, DAMPs, damage-associated molecular patterns, MHC, Major Histocompatibility Complex, biology.protein, IL-4, interleukin-4, RET, reverse electron transport, GABA, γ-amino butyric acid, HIF-1α, hypoxia inducible factor 1α, OAA, oxaloacetate, FAO, fatty acid oxidation, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b40b8a29dfcab6952141869277a440Test
https://doi.org/10.1016/j.jbc.2021.100904Test

المؤلفون: Yumi Nakamura, Masato Yasui, Fukui Yuko, Mariko Hara-Chikuma, Tsuchiya Takatsugu

المصدر: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 24, Iss, Pp 100864-(2020)

مصطلحات موضوعية: 0301 basic medicine, EGCG, (−)-epigallocatechin, Grape, Skin moisturization, Biochemistry, Wine grape, C, (−)-catechin, C–C, procyanidin B3, chemistry.chemical_compound, 0302 clinical medicine, RA, retinoic acid, lcsh:QD415-436, Gallic acid, Food science, C-EC, procyanidin B4, lcsh:QH301-705.5, EC-EC-EC, procyanidin C1, ECG, (−)-epicatechin gallate, chemistry.chemical_classification, integumentary system, EC-C, procyanidin B1, food and beverages, AQP3, aquaporin-3, medicine.anatomical_structure, Proanthocyanidin, Aquaporin 3, 030220 oncology & carcinogenesis, Research Article, Flavan-3-ol, Biophysics, lcsh:Biochemistry, 03 medical and health sciences, Stratum corneum, medicine, Oligomeric proanthocyanidin, OPC, oligomeric proanthocyanidin, EC, (−)-epicatechin, Wine, GA, gallic acid, In vitro, LC-TOF-MS, liquid chromatography/time-of-flight/mass spectrometry, PPARγ, peroxisome proliferator-activated receptor γ, 030104 developmental biology, lcsh:Biology (General), chemistry, Vitis vinifera, HIF-1α, hypoxia-inducible factor 1α, EC-EC, procyanidin B2, Aquaporin-3, NHEK, normal human epidermal keratinocytes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b011e8d56b043387e98a230d995be56Test
https://doi.org/10.1016/j.bbrep.2020.100864Test