نتائج البحث - "HF, high fat"

1

6-Gingerol Ameliorates Hepatic Steatosis via HNF4α/miR-467b-3p/GPAT1 CascadeSummary

المؤلفون: Chang Hwa Jung, Hyunjung Lee, Hyo-Deok Seo, Jiyun Ahn, Young In Kim, Tae-Youl Ha, Seung Yeon Ha

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1201-1213 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, Male, HFD, high-fat diet, Catechols, Gene Expression, ACC, acetyl-CoA carboxylase, RC799-869, Pathogenesis, Mice, 0302 clinical medicine, Genes, Reporter, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, miRNA, microRNA, Original Research, chemistry.chemical_classification, Chemistry, Fatty liver, Gastroenterology, MicroRNA, 1-Acylglycerol-3-Phosphate O-Acyltransferase, Diseases of the digestive system. Gastroenterology, mRNA, messenger RNA, ChIP, chromatin immunoprecipitation, Hepatocyte nuclear factors, HF, high-fat diet–fed group, UTR, untranslated region, Hepatocyte Nuclear Factor 4, 030211 gastroenterology & hepatology, RNA Interference, Fatty Alcohols, Intracellular, medicine.medical_specialty, TAG, triacylglycerol, DNL, de novo lipogenesis, HNF4α, hepatocyte nuclear factor 4α, 6-G, 6-gingerol, GPAT1, 03 medical and health sciences, Structure-Activity Relationship, cDNA, complementary DNA, GPAT, glycerol-3-phosphate acyltransferase, Internal medicine, NAFLD, microRNA, FFA, free fatty acid, medicine, Animals, Humans, HNF4α, Hepatology, DARTS, drug-affinity–responsive target stability, TLDA, TaqMan low-density arrays, Fatty acid, medicine.disease, Lipid Metabolism, Disease Models, Animal, MicroRNAs, 030104 developmental biology, Endocrinology, Gene Expression Regulation, LysoPA, lysophosphatidic acid, NAFLD, nonalcoholic fatty liver disease, Steatosis, 6-gingerol

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3294865d4fb01bb2374fab59ed3691Test
http://www.sciencedirect.com/science/article/pii/S2352345X21001223Test

2

High-fat diet activates liver iPLA2γ generating eicosanoids that mediate metabolic stress

المؤلفون: Shaoping Guan, Xinping Liu, Richard W. Gross, Harold F. Sims, Beverly Gibson Dilthey, Sung Ho Moon

المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100052-(2021)

مصطلحات موضوعية: 0301 basic medicine, obesity, Bioenergetics, AA, arachidonic acid, 030204 cardiovascular system & hematology, Mitochondrion, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, hydroxyeicosatetraenoic acids, 0302 clinical medicine, Endocrinology, mitochondrial respiration, EET, epoxyeicosatrienoic acid, HEPiPLA2γKO, hepatocyte-specific iPLA2γ-knockout, NDGA, nordihydroguaiaretic acid, ANT, adenine nucleotide translocase, LOX, lipoxygenase, LDH, lactate dehydrogenase, MPTP, phospholipases A2, mitochondria, cell death, NC, normal-chow, diet and dietary lipids, Research Article, medicine.medical_specialty, Programmed cell death, TAG, triacylglycerol, mPTP, mitochondrial permeability transition pore, QD415-436, Diet, High-Fat, eicosanoids, 03 medical and health sciences, Insulin resistance, HF, high-fat, Internal medicine, HETE, hydroxyeicosatetraenoic acid, FFA, free fatty acid, medicine, hepatocyte, FCCP, 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-propanedinitrile, iPLA2γ, calcium-independent phospholipase A2γ, mitochondrial permeability transition pore, Cell Biology, medicine.disease, AMPP, N-(4-aminomethylphenyl) pyridinium, 030104 developmental biology, chemistry, Mitochondrial permeability transition pore, Hepatic stellate cell, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac707a6479481fac40eba79f66d3ab5bTest
http://europepmc.org/articles/PMC8010217Test

3

The Structure and Function of the Human Small Intestinal Microbiota: Current Understanding and Future Directions

المؤلفون: Gary D. Wu, Arthur Kastl, Lindsey Albenberg, Natalie A. Terry

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 33-45 (2020)

مصطلحات موضوعية: 0301 basic medicine, Disease, Review, Pouchitis, IPAA, ileal pouch–anal anastomosis, SBS, short-bowel syndrome, Irritable Bowel Syndrome, 0302 clinical medicine, Small intestinal bacterial overgrowth, Intestine, Small, Function, Intestinal Mucosa, Irritable bowel syndrome, IBD, inflammatory bowel disease, Microbiota, Gastroenterology, medicine.anatomical_structure, BA, bile acid, Small Intestine, 030211 gastroenterology & hepatology, Sample collection, SIBO, small intestinal bacterial overgrowth, Blind Loop Syndrome, Short Bowel Syndrome, IBS, irritable bowel syndrome, Computational biology, Biology, EED, environmental enteric dysfunction, CFU, colony-forming units, 03 medical and health sciences, FXR, farnesoid X receptor, PN, parenteral nutrition, HF, high-fat, medicine, Dietary Carbohydrates, FAP, familial adenomatous polyposis, Animals, Humans, Microbiome, lcsh:RC799-869, Hepatology, Structure, Feeding Behavior, medicine.disease, Dietary Fats, Small intestine, Gastrointestinal Microbiome, GF, germ-free, UC, ulcerative colitis, Disease Models, Animal, 030104 developmental biology, Dysbiosis, lcsh:Diseases of the digestive system. Gastroenterology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f8557fbb801feaa7afdda0c8b8bbfaTest
http://europepmc.org/articles/PMC6881639Test

4

Metformin treatment reverses high fat diet- induced non-alcoholic fatty liver diseases and dyslipidemia by stimulating multiple antioxidant and anti-inflammatory pathways

المؤلفون: Ferdous Khan, Mohammad Maqsud Hossain, Didarul Islam, Shoumen Lasker, Ashraful Alam, Mizanur Rahman, Tahmina Yasmin, Raquibul Hasan, Sohel Rana, Fariha Kabir, Kamrun Nahar

المصدر: Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101168-(2021)
Biochemistry and Biophysics Reports

مصطلحات موضوعية: AST, aspartate aminotransferase, Protein oxidation, medicine.disease_cause, Biochemistry, LDL, low density lipoprotein, SOD, Superoxide dismutase, Lipid peroxidation, AUC, area under the curve, chemistry.chemical_compound, TBARS, Thiobarbituric acid reactive substances, Nonalcoholic fatty liver disease, OGTT, Oral glucose tolerance test, Biology (General), IL-6, interleukin-6, digestive, oral, and skin physiology, Fatty liver, PBS, Phosphate buffer saline, SREBP1c, sterol regulatory element-binding protein 1c, Malondialdehyde, Metformin, PGC-1α, peroxisome proliferator-activated receptor γ coactivator 1, ATP, Adinosine triphosphate, Research Article, medicine.drug, medicine.medical_specialty, QH301-705.5, HSCs, Hepatic stellate cells, MPO, Myeloperoxidase, Biophysics, QD415-436, IACUC, Institutional Animal Care and Use Committee, ROS, reactive oxygen species, ALT, alanine aminotransferase, Internal medicine, medicine, FAS, Fatty acid synthase, Obesity, MDA, Malondialdehyde, PPAR-γ, peroxisome proliferator-activated receptor γ, Inflammation, APOP, advanced protein oxidation product, NO, nitric oxide, ALP, alkaline phosphatase, business.industry, TBA, Thiobarbituric acid, nutritional and metabolic diseases, medicine.disease, HDL, high density lipoprotein, Met, Metformin, AMPK, AMP-activated protein kinase, Endocrinology, chemistry, HF, High fat, NAFLD, nonalcoholic fatty liver disease, CAT, catalase, Steatosis, business, Oxidative stress, Non-alcoholic fatty liver disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71282b5e76c3ceeef714c367923f6132Test
https://doi.org/10.1016/j.bbrep.2021.101168Test

5

Genome-wide circadian regulation: A unique system for computational biology

المؤلفون: Lingying Sun, Junjie Ma, Christoph W. Turck, Pin Xu, Guang-Zhong Wang

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1914-1924 (2020)

مصطلحات موضوعية: PER, Period, RF, Restricted feeding, Food intake, BMAL1, The aryl hydrocarbon receptor nuclear translocator-like (ARNTL), Energetic cost, Circadian transcriptome, LD, Light:dark, CCD, Cortical collecting duct, Review Article, SREBP, The sterol regulatory element binding protein, Biochemistry, Genome, Transcriptome, 0302 clinical medicine, Circadian regulation, Structural Biology, LS, Lomb-Scargle, ABSR, Autoregressive Bayesian spectral regression, ARSER, Harmonic regression based on autoregressive spectral estimation, Organism, HF, High fat diet, 0303 health sciences, LB, Ad libitum, RAIN, Rhythmicity Analysis Incorporating Nonparametric methods, CRY, Cryptochrome, JTK_CYCLE, Jonckheere-Terpstra-Kendall (JTK) cycle, Cycling genes, Computer Science Applications, Liver-RE, Liver clock reconstituted BMAL1-deficient mice, 030220 oncology & carcinogenesis, KD, Ketogenic diet, Biotechnology, NR, Night-restricted feeding, Positional cloning, lcsh:Biotechnology, Systems biology, Biophysics, Circadian regulatory network, Computational biology, Biology, 03 medical and health sciences, CR, Calorie-restricted diet, eJTK_CYCLE, Empirical JTK_CYCLE, NAD, Nicotinamide adenine dinucleotides, TTFL, Transcriptional-translational feedback loop, lcsh:TP248.13-248.65, Genetics, Circadian rhythms, Circadian rhythm, ND, Normal diet, SCN, Suprachiasmatic nucleus, PAS, PER-ARNT-SIM, 030304 developmental biology, AR, Arrhythmic feeding, DD, Dark: dark, AMPK, AMP-activated protein kinase, DCT/CNT, Distal convoluted tubule and connecting tubule, WT, Wild type

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3e2f2b6b0f53b6f9b9f0b638c1d68bTest
https://pubmed.ncbi.nlm.nih.gov/32774786Test

6

Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression

المؤلفون: Giuseppe Poli, Maria Blonda, Giorgia di Bello, Luigi Iuliano, Gaetano Serviddio, Gianluigi Vendemiale, Carlo Avolio, Giuseppina Iannelli, Antonio Facciorusso, Rosanna Tamborra, Francesco Bellanti, Rosanna Villani

المصدر: Redox Biology, Vol 15, Iss C, Pp 86-96 (2018)
Redox Biology

مصطلحات موضوعية: 0301 basic medicine, MMP, mitochondrial membrane potential, 5α, 6α-epoxy, 5α,6α-epoxycholesterol, Clinical Biochemistry, HF+HCh, high-fat+high-cholesterol, Respiratory chain, Apoptosis, Mitochondria, Liver, Mitochondrion, medicine.disease_cause, Biochemistry, SDM, standard deviation of the mean, cholesterol excess, fatty acids, mitochondria, non-alcoholic fatty liver disease, oxysterols, Nonalcoholic fatty liver disease, lcsh:QH301-705.5, ANOVA, analysis of variance, TNF, tumor necrosis factor, lcsh:R5-920, Chemistry, UCP2, uncoupling protein 2, Oxysterols, Cholesterol excess, Mitochondria, Mitochondrial respiratory chain, Lipotoxicity, Liver, CTRL, control, Disease Progression, lipids (amino acids, peptides, and proteins), FFAs, free fatty acids, lcsh:Medicine (General), Oxidation-Reduction, Research Paper, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, NASH, non-alcoholic steatohepatitis, Diet, High-Fat, 03 medical and health sciences, PA, palmitic acid, Δψ, mitochondrial membrane potential, HF, high-fat, Internal medicine, medicine, NAFL, non-alcoholic fatty liver, Humans, 5β, 6β-epoxy, 5β,6β-epoxycholesterol, Fatty acids, PGC1α, peroxisome proliferator-activated receptor-γ coactivator 1 α, TFAM, mitochondrial transcription factor A, NRF1, nuclear respiratory factor 1, Organic Chemistry, 6-oxo, 6-oxo-cholestan-3β,5α-diol, OA, oleic acid, CT, threshold cycle, medicine.disease, Lipid Metabolism, mtDNA, mitochondrial DNA, Oxidative Stress, 030104 developmental biology, Endocrinology, triol, 5α-cholestane-3β,5,6β-triol, Mitochondrial biogenesis, BN-PAGE, Blue Native bidimensional polyacrylamide gel electrophoresis, lcsh:Biology (General), Hepatocytes, 7β-OHC, 7β-hydroxycholesterol, Steatohepatitis, Reactive Oxygen Species, Oxidative stress, 7KC, 7-ketocholesterol, CYPs, cytochromes P450, Non-alcoholic fatty liver disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13897abda95ce40fb1e631f0e1a131eTest
http://www.sciencedirect.com/science/article/pii/S2213231717307425Test

7

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

المؤلفون: Jennifer E. Gallagher, Dorothy Kisielewski, John F. Dillon, Shaun V. Walsh, Diane Cassidy, David J. Harrison, Ritu Sharma, Tadashi Honda, John D. Hayes, Alison D. McNeilly, Michael L.J. Ashford, Albena T. Dinkova-Kostova, Rory J. McCrimmon

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 367-398 (2018)

مصطلحات موضوعية: NQO1, NAD(P)H:quinone oxidoreductase 1, TNF-α, tumor necrosis factor-α, IRE1α, inositol requiring kinase-1α, SCAD, short-chain acyl-CoA dehydrogenase, C/EBP, CCAAT/enhancer-binding protein, PCR, polymerase chain reaction, UPR, unfolded protein response, 0302 clinical medicine, Fibrosis, MGPAT, mitochondrial glycerol-3-phosphate acetyltransferase, ATF4, activating transcription factor-4, DGAT2, diacylglycerol acyltransferase-2, LXRα, liver X receptor α, Glucose homeostasis, eIf2α, eukaryotic translation initiation factor 2A, IKK, IκB kinase, ACOT7, acetyl-CoA thioesterase 7, Original Research, TGFβ, transforming growth factor beta-1, SLC7A11, solute carrier family 7 member 11, GSSG, oxidized glutathione, MTTP, microsomal triglyceride transfer protein, NASH, Gastroenterology, TXN1, thioredoxin-1, 3. Good health, ChREBP, carbohydrate-responsive element-binding protein, 030220 oncology & carcinogenesis, NASH, nonalcoholic steatohepatitis, medicine.medical_specialty, PARP, poly ADP ribose polymerase, qRT-PCR, quantitative reverse transcriptase PCR, GSTM1, glutathione S-transferase Mu-1, GCLC, glutamate-cysteine ligase catalytic, Nrf2, ACACA, acetyl-CoA carboxylase alpha, 03 medical and health sciences, FXR, farnesoid X receptor, Nrf2, NF-E2 p45-related factor 2, COX2, cyclooxygenase-2, Keap1, Kelch-like ECH-associated protein-1, PPARα, peroxisome proliferator-activated receptor α, PTT, pyruvate tolerance test, HMOX1, heme oxygenase-1, RC, regular chow, p58IPK, p58 inhibitor of the PKR kinase, medicine.disease, TBE-31, 030104 developmental biology, Endocrinology, COL1A1, collagen, type I, alpha-1, Unfolded protein response, CAT, catalase, 0301 basic medicine, PDI, protein disulfide isomerase, GSH, reduced glutathione, FASN, fatty acid synthase, BCL-2, B-cell lymphoma, MPO, myeloperoxidase, AP-1, activator protein 1, DMSO, dimethyl sulfoxide, medicine.disease_cause, SHP, small heterodimer partner, CDDO, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid, CHOP, C/EBP homologous protein, TXNRD1, thioredoxin reductase-1, HF30Fr, high-fat diet with 30% fructose in drinking water, IκB, inhibitor of NF-κB, SFN, sulforaphane, ADRP, adipose differentiation-related protein, NAS, NAFLD activity score, GPX2, glutathione peroxidase-2, Chemistry, MCP-1, monocyte chemotactic protein-1, XBP1, X-box binding protein-1, SREBP-1c, sterol regulatory element-binding protein-1c, Lipogenesis, GTT, glucose tolerance test, PERK, PRK-like endoplasmic reticulum kinase, PTGR1, prostaglandin reductase-1, GSTA4, glutathione S-transferase Alpha-4, medicine.symptom, NAFLD, non-alcoholic fatty liver disease, α-SMA, alpha smooth muscle actin, ACOX2, acetyl-CoA oxidase 2, HFFr, high-fat diet with fructose in drinking water, NF-κB, nuclear factor-κB, GCLM, glutamate-cysteine ligase modifier, Inflammation, JNK1, c-Jun N-terminal kinase 1, CD36, cluster of differentiation 36, ER, endoplasmic reticulum, Insulin resistance, HF, high-fat, HF55Fr, high-fat diet with 55% fructose in drinking water, Internal medicine, ATF6, activating transcription factor-6, medicine, ApoB, apolipoprotein B, lcsh:RC799-869, CES1G, carboxylesterase 1g, ITT, insulin tolerance test, MCD, methionine- and choline-deficient, ACLY, ATP citrate lyase, Hepatology, SCD1, stearoyl-CoA desaturase-1, NOS2, nitric oxide synthase-2, PRDX6, peroxiredoxin 6, PPARγ, peroxisome proliferator-activated receptor γ, BIP, binding immunoglobulin protein, H&E, hematoxylin and eosin, lcsh:Diseases of the digestive system. Gastroenterology, Steatosis, CPT1A, carnitine palmitoyltransferase 1a, Oxidative stress