نتائج البحث - "HET, Heterozygous"

1

High-throughput genotyping of high-homology mutant mouse strains by next-generation sequencing

المؤلفون: Shaheen Akhtar, Joanna Bottomley, Edward Ryder, Daniel M Barrett, Michaela Bruntraeger, Sanger Mouse Genetics, James Bussell, Jonathan Burvill, Radka Platte, Debarati Sethi, Diane Gleeson

المصدر: Methods (San Diego, Calif.)

مصطلحات موضوعية: FASTQ format, Genotyping, Genotype, Genotyping Techniques, Mouse, Computational biology, Biology, Polymerase Chain Reaction, Genome, Article, General Biochemistry, Genetics and Molecular Biology, DNA sequencing, Mice, 03 medical and health sciences, PCR, polymerase chain reaction, Animals, CRISPR, CRISPR, clustered regularly interspaced short palindromic repeat, hom, homozygous, Allele, Molecular Biology, Alleles, QC, 030304 developmental biology, 0303 health sciences, fungi, 030302 biochemistry & molecular biology, sgRNA, single guide RNA, Mutant, food and beverages, High-Throughput Nucleotide Sequencing, NGS, next generation sequencing, het, heterozygous, Amplicon, WT, wild-type, Mice, Mutant Strains, QC, quality control, NHEJ, non-homologous end joining, NGS

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef79b367f901763da5e833510b51bcdcTest
https://doi.org/10.1016/j.ymeth.2020.10.011Test

2

Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes

المؤلفون: Chakera, Ali J., Hurst, Paul S., Spyer, Gill, Ogunnowo-Bada, Emmanuel O., Marsh, William J., Riches, Christine H., Yueh, Chen-Yu, Markkula, S. Pauliina, Dalley, Jeffrey W., Cox, Roger D., Macdonald, Ian A., Amiel, Stephanie A., MacLeod, Kenneth M., Heisler, Lora K., Hattersley, Andrew T., Evans, Mark L.

المساهمون: Dalley, Jeffrey [0000-0002-2282-3660], Evans, Mark [0000-0001-8122-8987], Apollo - University of Cambridge Repository

المصدر: Molecular Metabolism, Vol 17, Iss, Pp 17-27 (2018)
Chakera, A J, Hurst, P S, Spyer, G, Ogunnowo-Bada, E O, Marsh, W J, Riches, C H, Yueh, C Y, Markkula, S P, Dalley, J W, Cox, R D, Macdonald, I A, Amiel, S A, MacLeod, K M, Heisler, L K, Hattersley, A T & Evans, M L 2018, ' Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes ', Molecular Metabolism . https://doi.org/10.1016/j.molmet.2018.08.001Test
Molecular Metabolism

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3790757ba77e77647b9ef28458dabd9aTest
http://www.sciencedirect.com/science/article/pii/S2212877818307506Test

3

Hop2 interacts with the transcription factor CEBPα and suppresses adipocyte differentiation

المؤلفون: Yang Zhang, Rita A. Steckler, Xiangli Yang, Tonghui Lin, Tingting Zhang

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: ATF4, activating transcription factor 4, TF, transcription factor, Hop2, An, adiponectin, Adipose tissue, Cell Cycle Proteins, Ab, antibody, Pepck, phosphoenolpyruvate carboxykinase, Biochemistry, Mice, Transactivation, chemistry.chemical_compound, Adipocyte, transcription factor, Mice, Knockout, qRT–PCR, quantitative RT–PCR, Adipogenesis, Ccaat-enhancer-binding proteins, biology, C3, complement 3, Chemistry, CEBPα, VAT, visceral adipose tissue, Cell Differentiation, 3T3 Cells, differentiation, het, heterozygous, Neo, neomycin-resistant gene, Lep, leptin, Cell biology, CEBP, CCAAT enhancer binding protein, ChIP, chromatin immunoprecipitation, ON, overnight, NE, nuclear extract, Dgat, diglyceride acyltransferase, Research Article, adipocytes, ORO, Oil Red O, CD36, cluster of differentiation 36, Hop2, homologous pairing protein 2, cDNA, complementary DNA, aMSC, adipocyte-derived mesenchymal stem cell, GST, glutathione-S-transferase, Animals, adipocyte protein 2, Molecular Biology, Transcription factor, co-IP, coimmunoprecipitation, Cell Biology, Antigens, Differentiation, Glut4, glucose transporter 4, PPARγ, peroxisome proliferator–activated receptor γ, aP2, adipocyte protein 2, Gene Expression Regulation, CCAAT-Enhancer-Binding Proteins, biology.protein, HA-Hop2, HA-tagged Hop2, Chromatin immunoprecipitation, HA, hemagglutinin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322a2e4a50834fb6641d926cce968207Test
https://doi.org/10.1016/j.jbc.2021.101264Test

4

Hepatocyte-Specific Deletion of Mouse Lamin A/C Leads to Male-Selective Steatohepatitis

المؤلفون: Xin Tong, Lei Yin, Ram K. Menon, Colin L. Stewart, Min-Jung Park, Makayla J. Brunt, M. Bishr Omary, Raymond Kwan, Maria Brzozowski, Graham F. Brady, Sujith V.W. Weerasinghe, Hope Martin

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 4, Iss 3, Pp 365-383 (2017)

مصطلحات موضوعية: WT, wild type, 0301 basic medicine, Premature aging, HFD, high-fat diet, Stat, signal transducer and activator of transcription, Nonalcoholic Fatty Liver Disease, Lipodystrophy, Laminopathy, Growth Hormone Signaling, % liver weight, liver percentage of body mass, PBS, phosphate-buffered saline, Igf1, insulin-like growth factor 1, Biology, FPLD2, Dunnigan familial partial lipodystrophy, Het, heterozygous, Erk, extracellular signal–regulated kinase, LMNA, 03 medical and health sciences, Hepatocyte homeostasis, Jak2, Janus kinase 2, medicine, lcsh:RC799-869, STAT5, Original Research, KO, knockout, Hepatology, ND, normal diet, Gastroenterology, medicine.disease, Fibrosis, GH, growth hormone, 3. Good health, Cell biology, 030104 developmental biology, Cancer research, biology.protein, qPCR, quantitative polymerase chain reaction, Nuclear lamina, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease, Steatohepatitis, Lamin