دورية أكاديمية
Genome-wide association studies to identify quantitative trait loci and positional candidate genes affecting meat quality-related traits in pigs
| العنوان: | Genome-wide association studies to identify quantitative trait loci and positional candidate genes affecting meat quality-related traits in pigs |
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| المؤلفون: | Jae-Bong Lee, Ji-Hoon Lim, Hee-Bok Park |
| المصدر: | Journal of Animal Science and Technology, Vol 65, Iss 6, Pp 1194-1204 (2023) |
| بيانات النشر: | Korean Society of Animal Sciences and Technology, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Animal culture |
| مصطلحات موضوعية: | Genome-wide association study (GWAS), Meat quality-related traits, HAUS8, lnc RNA, Pig, Animal culture, SF1-1100 |
| الوصف: | Meat quality comprises a set of key traits such as pH, meat color, water-holding capacity, tenderness and marbling. These traits are complex because they are affected by multiple genetic and environmental factors. The aim of this study was to investigate the molecular genetic basis underlying nine meat quality-related traits in a Yorkshire pig population using a genome-wide association study (GWAS) and subsequent biological pathway analysis. In total, 45,926 single nucleotide polymorphism (SNP) markers from 543 pigs were selected for the GWAS after quality control. Data were analyzed using a genome-wide efficient mixed model association (GEMMA) method. This linear mixed model-based approach identified two quantitative trait loci (QTLs) for meat color (b*) on chromosome 2 (SSC2) and one QTL for shear force on chromosome 8 (SSC8). These QTLs acted additively on the two phenotypes and explained 3.92%–4.57% of the phenotypic variance of the traits of interest. The genes encoding HAUS8 on SSC2 and an lncRNA on SSC8 were identified as positional candidate genes for these QTLs. The results of the biological pathway analysis revealed that positional candidate genes for meat color (b*) were enriched in pathways related to muscle development, muscle growth, intramuscular adipocyte differentiation, and lipid accumulation in muscle, whereas positional candidate genes for shear force were overrepresented in pathways related to cell growth, cell differentiation, and fatty acids synthesis. Further verification of these identified SNPs and genes in other independent populations could provide valuable information for understanding the variations in pork quality-related traits. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2672-0191 2055-0391 |
| العلاقة: | http://www.ejast.org/archive/view_article?doi=10.5187/jast.2023.e70Test; https://doaj.org/toc/2672-0191Test; https://doaj.org/toc/2055-0391Test |
| DOI: | 10.5187/jast.2023.e70 |
| الوصول الحر: | https://doaj.org/article/9162b9cb4f97468e88b728ff3545a968Test |
| رقم الانضمام: | edsdoj.9162b9cb4f97468e88b728ff3545a968 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26720191 20550391 |
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| DOI: | 10.5187/jast.2023.e70 |