دورية أكاديمية
Evaluation of Lipocalin-2 and Twist expression in thyroid cancers and its relationship with epithelial mesenchymal transition
| العنوان: | Evaluation of Lipocalin-2 and Twist expression in thyroid cancers and its relationship with epithelial mesenchymal transition |
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| المؤلفون: | Celepli P., Bigat, Ä°rem, Karabulut S., Celepli S., HücümenoÄŸlu S. |
| بيانات النشر: | W.B. Saunders |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Epithelial-mesenchymal transition, Lipocalin-2, Thyroid cancer, Twist, biological marker, eosin, hematoxylin, neutrophil gelatinase associated lipocalin, transcription factor Twist, uvomorulin, vimentin, adult, aged, Article, carcinoma in situ, controlled study, epithelial mesenchymal transition, female, histopathology, human, human tissue, immunohistochemistry, lymph node metastasis, major clinical study, male, nodular hyperplasia, protein expression, thyroid adenoma, thyroid follicular carcinoma, thyroid hyperplasia |
| الوصف: | Objective: To evaluate the expressions of lipocalin-2 (LCN-2) and Twist in thyroid cancers and examine its relationship with epithelial-to-mesenchymal transition (EMT) and clinicopathological factors. Materials and methods: The expression of LCN-2 and Twist was immunohistochemically evaluated in a total of 249 cases, including 120 patients with papillary thyroid carcinomas (PTC), 34 with follicular thyroid carcinoma (FTC), 15 with medullary thyroid carcinomas (MTC), 20 with non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), 47 with follicular adenomas (FA), and 13 with nodular hyperplasia (NH). In addition, the relationship between the expression of EMT markers E-cadherin and vimentin was investigated in malignant cases. Results: A significant increase was observed in the LCN-2 and Twist expression from NH and FA to NIFTP, MTC, FTC, and PTC (p = 0.001). A high degree of LCN-2 expression was observed in the aggressive variants of PTC (p = 0.002). Twisthigh positivity was significantly higher in cases with the EMT-positive mesenchymal phenotype (p = 0.036). Conclusions: LCN-2 and Twist can be helpful diagnostic markers in the differentiation of benign and malignant thyroid nodules. Twisthigh expression supports the EMT process in thyroid cancer. LCN-2 and Twist expression may also serve as valuable predictive biomarkers in patients with thyroid cancer. In future, the determination of a LCN-2high expression in the aggressive variants of PTC may be integrated into targeted treatment strategies. © 2022 Elsevier Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1092-9134 |
| العلاقة: | Annals of Diagnostic Pathology; Makale - Uluslararası Hakemli Dergi - Ä°dari Personel ve Öğrenci; https://hdl.handle.net/20.500.11851/8633Test; https://doi.org/10.1016/j.anndiagpath.2022.151973Test; 59; WOS:000836436500003; 2-s2.0-85129955881; Q2 |
| DOI: | 10.1016/j.anndiagpath.2022.151973 |
| الإتاحة: | https://doi.org/20.500.11851/863310.1016/j.anndiagpath.2022.151973Test https://hdl.handle.net/20.500.11851/8633Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.BBE8EB83 |
| قاعدة البيانات: | BASE |
| تدمد: | 10929134 |
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| DOI: | 10.1016/j.anndiagpath.2022.151973 |