Cerebral vasoconstriction reactions and plasma levels of ETBR, ET-1, and eNOS in patients with chronic high altitude disease
| العنوان: | Cerebral vasoconstriction reactions and plasma levels of ETBR, ET-1, and eNOS in patients with chronic high altitude disease |
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| المؤلفون: | Shizheng Wu, Tana Wuren, Junming Luo, Guisheng Hao, Dongmei Jiang, Shukun Zhang |
| المصدر: | Molecular Medicine Reports |
| بيانات النشر: | Spandidos Publications, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Cancer Research, Cerebral arteries, Blood Pressure, Constriction, Pathologic, Altitude Sickness, 030204 cardiovascular system & hematology, Biochemistry, 0302 clinical medicine, Heart Rate, Enos, health care economics and organizations, Altitude sickness, chronic mountain sickness, Endothelin-1, biology, Cerebral infarction, Articles, Middle Aged, Receptor, Endothelin B, Chronic mountain sickness, Oncology, endothelin B receptor, Cardiology, Molecular Medicine, Female, medicine.symptom, Adult, medicine.medical_specialty, Nitric Oxide Synthase Type III, cerebrovascular reactivity, Young Adult, 03 medical and health sciences, health services administration, Internal medicine, Genetics, medicine, Humans, Molecular Biology, endothelial nitric oxide synthase, business.industry, Cerebral Arteries, medicine.disease, biology.organism_classification, Endothelin 1, Transcranial Doppler, Vasoconstriction, Case-Control Studies, Immunology, business, Biomarkers, 030217 neurology & neurosurgery |
| الوصف: | The aim of the present study was to examine cerebral vasoconstriction in patients with chronic high altitude disease [cerebrovascular reactivity (CVR)], and to evaluate differences in alterations of brain vascular contractile reactivity of chronic mountain sickness (CMS) patients and healthy controls. Alterations of endothelin (ET) and its receptor, as well as endothelial nitric oxide synthase (eNOS) levels in the plasma were examined to determine the cerebral reservation capacities in CMS patients. Transcranial Doppler ultrasound and carbon dioxide analysis methods were used to detect the CVR variances. At the same time, enzyme-linked immunosorbent assay approaches were utilized to detect the ET and ET B receptor and the eNOS levels in serum of the CMS patients and healthy controls. CVR and CVRI levels in CMS patients were lower than those of the healthy control subjects and the difference was statistically significant (P0.05). However, the ET receptor concentration level was higher in CMS than the healthy controls. Thus, ET-1 may not be a direct etiological variation but may play compensatory roles in CMS patients. The results of the study may provide scientific clues for the prevention and treatment of CMS with higher blood coagulation states of cerebral infarction in patients with chronic high altitude disease. |
| تدمد: | 1791-3004 1791-2997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7961b244fd51aa836de7e8ccb97425Test https://doi.org/10.3892/mmr.2016.5555Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7b7961b244fd51aa836de7e8ccb97425 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17913004 17912997 |
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