المؤلفون: Helmut Pein, Alexia Ville, Simona Pace, Veronika Temml, Ulrike Garscha, Martin Raasch, Khaled Alsabil, Guillaume Viault, Chau-Phi Dinh, David Guilet, Fabiana Troisi, Konstantin Neukirch, Stefanie König, Rosella Bilancia, Birgit Waltenberger, Hermann Stuppner, Maria Wallert, Stefan Lorkowski, Christina Weinigel, Silke Rummler, Marc Birringer, Fiorentina Roviezzo, Lidia Sautebin, Jean-Jacques Helesbeux, Denis Séraphin, Alexander S. Mosig, Daniela Schuster, Antonietta Rossi, Pascal Richomme, Oliver Werz, Andreas Koeberle

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/8f5b1e43017943509f14b4b68fe07ec5Test

المؤلفون: Gabriele Möller, Veronika Temml, Antonio Cala Peralta, Océane Gruet, Pascal Richomme, Denis Séraphin, Guillaume Viault, Luisa Kraus, Petra Huber-Cantonati, Elisabeth Schopfhauser, Johanna Pachmayr, Janina Tokarz, Daniela Schuster, Jean-Jacques Helesbeux, Kenneth Allen Dyar

المصدر: Metabolites, Vol 12, Iss 2, p 99 (2022)

مصطلحات موضوعية: chalcone, aldo-keto reductase, cancer, AKR1C3, 17β-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, Microbiology, QR1-502

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2218-1989/12/2/99Test; https://doaj.org/toc/2218-1989Test

الوصول الحر: https://doaj.org/article/2ab68851bb2c41d1830b279e836dcadfTest

المؤلفون: Konstantin Neukirch (11153961), Khaled Alsabil (11153964), Chau-Phi Dinh (11153967), Rossella Bilancia (11153970), Martin Raasch (11153973), Alexia Ville (6195272), Ida Cerqua (6865439), Guillaume Viault (5536127), Dimitri Bréard (5536124), Simona Pace (1779802), Veronika Temml (1308846), Elena Brunner (11153976), Paul M. Jordan (1449052), Marta C. Marques (5006471), Konstantin Loeser (11153979), André Gollowitzer (11153982), Stephan Permann (11153985), Jana Gerstmeier (468479), Stefan Lorkowski (16019), Hermann Stuppner (388594), Ulrike Garscha (1811065), Tiago Rodrigues (468531), Gonçalo J. L. Bernardes (7319006), Daniela Schuster (129641), Denis Séraphin (6195278), Pascal Richomme (591385), Antonietta Rossi (1779796), Alexander S. Mosig (11153988), Fiorentina Roviezzo (2512720), Oliver Werz (468489), Jean-Jacques Helesbeux (2130412), Andreas Koeberle (1426642)

مصطلحات موضوعية: Biochemistry, Genetics, Physiology, Pharmacology, Immunology, Cancer, Mental Health, Hematology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, semisynthesized analogues, stability, lipid mediator biosynthesis, proresolving lipid mediator, Pharmacokinetic studies show distri., LCM-inspired drug candidate, limits inflammation, murine peritonitis, prostaglandin E 2 synthase -1, α- amplexichromanol, Limits Inflammation Endogenous long., Long-Chain Vitamin E Metabolites, vitamin E, 5- LOX, 5- LOX-derived leukotriene levels d., SAR studies, β- oxidation, Other enzymes

العلاقة: https://figshare.com/articles/journal_contribution/Exploration_of_Long-Chain_Vitamin_E_Metabolites_for_the_Discovery_of_a_Highly_Potent_Orally_Effective_and_Metabolically_Stable_5_LOX_Inhibitor_that_Limits_Inflammation/15016581Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00806.s001Test

المؤلفون: Rodolphe Perrot, Jean-Jacques Helesbeux, Denis Séraphin, Marie Kempf, Pascal Richomme, Khaled Alsabil, Guillaume Viault, Alexia Ville

المساهمون: Substances d'Origine Naturelle et Analogues Structuraux (SONAS), Université d'Angers (UA), Département de biologie des agents infectieux et pharmacotoxicologie, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Service Commun d'Imagerie et d'Analyse Microscopique (SCIAM)

المصدر: ChemMedChem
ChemMedChem, Wiley-VCH Verlag, 2021, 16 (5), pp.881-890. ⟨10.1002/cmdc.202000792⟩

مصطلحات موضوعية: Staphylococcus aureus, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Microbial Sensitivity Tests, medicine.disease_cause, 01 natural sciences, Biochemistry, Bacterial cell structure, Microbiology, Structure-Activity Relationship, Staphylococcus epidermidis, Drug Discovery, medicine, Vitamin E, [CHIM]Chemical Sciences, General Pharmacology, Toxicology and Pharmaceutics, Cytotoxicity, ComputingMilieux_MISCELLANEOUS, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, biology.organism_classification, Semisynthesis, Methicillin-resistant Staphylococcus aureus, Anti-Bacterial Agents, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Methicillin Resistance, Antibacterial activity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490659c4c8c7aed149cab7177434bb72Test
https://doi.org/10.1002/cmdc.202000792Test

المؤلفون: Jimmy Josué Ceballos-Cruz, Jean-Jacques Hélesbeux, Guillaume Viault, Denis Séraphin, Gumersindo Mirón-López, Rubén M. Carballo, Pascal Richomme, Luis Manuel Peña-Rodríguez

المصدر: Journal of the Mexican Chemical Society. 66

مصطلحات موضوعية: General Chemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7251a2f3e2ad9290a013a26a385b33ffTest
https://doi.org/10.29356/jmcs.v66i1.1670Test

المؤلفون: Stephan Permann, Konstantin Neukirch, Jean-Jacques Helesbeux, Guillaume Viault, Chau-Phi Dinh, Elena Brunner, Oliver Werz, Denis Seraphin, Pascal Richomme, Andreas Koeberle

المصدر: Planta Medica.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c50509fd4fc97ac612935a54d18f6f8fTest
https://doi.org/10.1055/s-0041-1736935Test

المؤلفون: Denis Séraphin, Christian Kretzer, Markus Werner, Pascal Richomme, Andreas Koeberle, Veronika Temml, Paul M. Jordan, Jean-Jacques Helesbeux, Daniela Schuster, Katharina P.L. Meyer, Robert Klaus Hofstetter, Guillaume Viault, Antonio Cala Peralta, Hermann Stuppner, Daniel Hoff, Oliver Werz

المصدر: Biochemical pharmacology. 195

مصطلحات موضوعية: Adult, Chalcone, Leukotrienes, Cell Survival, Annonaceae, Arachidonate 12-Lipoxygenase, Biochemistry, chemistry.chemical_compound, Lipoxygenase, Chalcones, Biosynthesis, Macrophage, Arachidonate 15-Lipoxygenase, Humans, Cells, Cultured, Pharmacology, integumentary system, biology, Molecular Structure, Chemistry, Plant Extracts, Macrophages, HEK 293 cells, food and beverages, Dihydrochalcone, Lipid signaling, Transfection, Macrophage Activation, HEK293 Cells, biology.protein, Prostaglandins, lipids (amino acids, peptides, and proteins)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8baf0cc99b4fbc5fbcb7fd425e09c4Test
https://pubmed.ncbi.nlm.nih.gov/34762841Test

المؤلفون: Simona Pace, Daniela Schuster, Marc Birringer, Maria Wallert, Christina Weinigel, Hermann Stuppner, Denis Séraphin, David Guilet, Veronika Temml, Martin Raasch, Silke Rummler, Helmut Pein, Fiorentina Roviezzo, Jean-Jacques Helesbeux, Rosella Bilancia, Lidia Sautebin, Stefanie König, Guillaume Viault, Chau-Phi Dinh, Alexia Ville, Ulrike Garscha, Birgit Waltenberger, Alexander S. Mosig, Stefan Lorkowski, Andreas Koeberle, Fabiana Troisi, Pascal Richomme, Oliver Werz, Khaled Alsabil, Antonietta Rossi, Konstantin Neukirch

المساهمون: Pein, Helmut, Ville, Alexia, Pace, Simona, Temml, Veronika, Garscha, Ulrike, Raasch, Martin, Alsabil, Khaled, Viault, Guillaume, Dinh, Chau-Phi, Guilet, David, Troisi, Fabiana, Neukirch, Konstantin, König, Stefanie, Bilancia, Rosella, Waltenberger, Birgit, Stuppner, Hermann, Wallert, Maria, Lorkowski, Stefan, Weinigel, Christina, Rummler, Silke, Birringer, Marc, Roviezzo, Fiorentina, Sautebin, Lidia, Helesbeux, Jean-Jacque, Séraphin, Deni, Mosig, Alexander S., Schuster, Daniela, Rossi, Antonietta, Richomme, Pascal, Werz, Oliver, Koeberle, Andreas, Substances d'Origine Naturelle et Analogues Structuraux (SONAS), Université d'Angers (UA)

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.3834. ⟨10.1038/s41467-018-06158-5⟩

مصطلحات موضوعية: 0301 basic medicine, [SDV]Life Sciences [q-bio], Metabolite, medicine.medical_treatment, General Physics and Astronomy, Pharmacology, chemistry.chemical_compound, Mice, 0302 clinical medicine, Leukocytes, Vitamin E, Lipoxygenase Inhibitors, lcsh:Science, Multidisciplinary, biology, Chemistry (all), Middle Aged, Recombinant Proteins, 3. Good health, Liver, 030220 oncology & carcinogenesis, Arachidonate 5-lipoxygenase, Metabolome, medicine.symptom, Bronchial Hyperreactivity, Adult, Cell signaling, Adolescent, Cell Survival, Science, Inflammation, Peritonitis, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Physics and Astronomy (all), Inhibitory Concentration 50, Young Adult, Immune system, medicine, Animals, Humans, Aged, Biochemistry, Genetics and Molecular Biology (all), Arachidonate 5-Lipoxygenase, Cell-Free System, General Chemistry, Lipid signaling, 030104 developmental biology, chemistry, biology.protein, lcsh:Q

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfee7afdff0d4990f14ad8886b080055Test
http://link.springer.com/article/10.1038/s41467-018-06158-5Test

المؤلفون: Andreas Koeberle, Denis Séraphin, Stefan Lorkowski, Tiago Rodrigues, Oliver Werz, Daniela Schuster, Dimitri Bréard, Hermann Stuppner, Ida Cerqua, Antonietta Rossi, Simona Pace, Marta C. Marques, Alexander S. Mosig, Paul M. Jordan, Stephan Permann, Jana Gerstmeier, Martin Raasch, Gonçalo J. L. Bernardes, André Gollowitzer, Ulrike Garscha, Chau-Phi Dinh, Alexia Ville, Jean-Jacques Helesbeux, Fiorentina Roviezzo, Guillaume Viault, Elena Brunner, Pascal Richomme, Veronika Temml, Rossella Bilancia, Khaled Alsabil, Konstantin Loeser, Konstantin Neukirch

المساهمون: Neukirch, K., Alsabil, K., Dinh, C. -P., Bilancia, R., Raasch, M., Ville, A., Cerqua, I., Viault, G., Breard, D., Pace, S., Temml, V., Brunner, E., Jordan, P. M., Marques, M. C., Loeser, K., Gollowitzer, A., Permann, S., Gerstmeier, J., Lorkowski, S., Stuppner, H., Garscha, U., Rodrigues, T., Bernardes, G. J. L., Schuster, D., Seraphin, D., Richomme, P., Rossi, A., Mosig, A. S., Roviezzo, F., Werz, O., Helesbeux, J. -J., Koeberle, A., Neukirch, Konstantin [0000-0003-0630-1624], Dinh, Chau-Phi [0000-0002-3683-3472], Gollowitzer, André [0000-0003-1524-8298], Stuppner, Hermann [0000-0001-8862-0201], Rodrigues, Tiago [0000-0002-1581-5654], Bernardes, Gonçalo J L [0000-0001-6594-8917], Schuster, Daniela [0000-0002-9933-8938], Séraphin, Denis [0000-0002-0509-5788], Mosig, Alexander S [0000-0002-5687-2444], Werz, Oliver [0000-0002-5064-4379], Koeberle, Andreas [0000-0001-6269-5088], Apollo - University of Cambridge Repository, Bernardes, Gonçalo JL [0000-0001-6594-8917]

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: medicine.medical_treatment, Administration, Oral, Inflammation, Endogeny, Lipoxygenase Inhibitor, Pharmacology, Article, chemistry.chemical_compound, Structure-Activity Relationship, Immune system, Drug Discovery, medicine, Humans, Vitamin E, Lipoxygenase Inhibitors, Prostaglandin E2, Leukotriene, Arachidonate 5-Lipoxygenase, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Lipid signaling, Recombinant Protein, Recombinant Proteins, Molecular Docking Simulation, Molecular Medicine, medicine.symptom, Resolvin, medicine.drug, Human

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197aa94407387a7b89fbecdcc110c28aTest
http://hdl.handle.net/11588/879642Test

المؤلفون: Dong Tien Tran, Laëtitia Minder, Laurent Pouységu, Denis Deffieux, Elisabeth Génot, Yoan Capello, Carmelo Di Primo, Philippe A. Peixoto, Sofiane Dairi, Stéphane Quideau, Guillaume Viault, Daniela Melanie Delannoy López

المساهمون: Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB), Soutien à la Recherche de l'Institut Européen de Chimie Biologique, Université Sciences et Technologies - Bordeaux 1 (UB)-Institut Européen de Chimie et de Biologie-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Acides Nucléiques : Régulations Naturelle et Artificielle (ARNA), Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Peixoto, Philippe, Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Européen de Chimie et de Biologie-Université Sciences et Technologies - Bordeaux 1-Institut de Chimie du CNRS (INC)

المصدر: Chemistry-A European Journal
Chemistry-A European Journal, In press, ⟨10.1002/chem.202005187⟩
Chemistry-A European Journal, Wiley-VCH Verlag, In press, ⟨10.1002/chem.202005187⟩

مصطلحات موضوعية: [SDV]Life Sciences [q-bio], Epigallocatechin gallate, Ligands, 010402 general chemistry, 01 natural sciences, Catalysis, Protein–protein interaction, chemistry.chemical_compound, [CHIM] Chemical Sciences, Humans, [CHIM]Chemical Sciences, Surface plasmon resonance, Bovine serum albumin, Procyanidin B2, polyphenols, Flavonoids, Piceatannol, biology, 010405 organic chemistry, Organic Chemistry, food and beverages, Catechin, General Chemistry, proteins, 0104 chemical sciences, [SDV] Life Sciences [q-bio], analytical methods, Biochemistry, chemistry, Polyphenol, immobilization, biology.protein, Streptavidin, surface plasmon resonance

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf20b83a5d7603b8a70defcf679ce2e1Test
https://hal.science/hal-03374449Test