دورية أكاديمية
Pathogenesis of Penile Squamous Cell Carcinoma: Molecular Update and Systematic Review.
| العنوان: | Pathogenesis of Penile Squamous Cell Carcinoma: Molecular Update and Systematic Review. |
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| المؤلفون: | Ribera-Cortada, I., Guerrero-Pineda, J., Trias, I., Veloza, L., Garcia, A., Marimon, L., Diaz-Mercedes, S., Alamo, J.R., Rodrigo-Calvo, M.T., Vega, N., López Del Campo, R., Parra-Medina, R., Ajami, T., Martínez, A., Reig, O., Ribal, M.J., Corral-Molina, J.M., Jares, P., Ordi, J., Rakislova, N. |
| المصدر: | International journal of molecular sciences, vol. 23, no. 1, pp. 251 |
| سنة النشر: | 2021 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Carcinoma, Squamous Cell/etiology, Squamous Cell/genetics, Squamous Cell/pathology, Squamous Cell/virology, DNA Copy Number Variations/genetics, Geography, Humans, Male, Molecular Targeted Therapy, Mutation/genetics, Papillomaviridae/physiology, Penile Neoplasms/etiology, Penile Neoplasms/genetics, Penile Neoplasms/pathology, Penile Neoplasms/virology, Prognosis, Signal Transduction, HPV, genomic landscape, molecular analysis, next generation sequencing, penile cancer, penile squamous cell carcinoma, whole-exome sequencing |
| الوصف: | Penile squamous cell carcinoma (PSCC) is a rare but aggressive neoplasm with dual pathogenesis (human papillomavirus (HPV)-associated and HPV-independent). The development of targeted treatment is hindered by poor knowledge of the molecular landscape of PSCC. We performed a thorough review of genetic alterations of PSCC focused on somatic mutations and/or copy number alterations. A total of seven articles have been identified which, overall, include 268 PSCC. However, the series are heterogeneous regarding methodologies employed for DNA sequencing and HPV detection together with HPV prevalence, and include, in general, a limited number of cases, which results in markedly different findings. Reported top-ranked mutations involve TP53, CDKN2A, FAT1, NOTCH-1 and PIK3CA. Numerical alterations involve gains in MYC and EGFR, as well as amplifications in HPV integration loci. A few genes including TP53, CDKN2A, PIK3CA and CCND1 harbor both somatic mutations and copy number alterations. Notch, RTK-RAS and Hippo pathways are frequently deregulated. Nevertheless, the relevance of the identified alterations, their role in signaling pathways or their association with HPV status remain elusive. Combined targeting of different pathways might represent a valid therapeutic approach in PSCC. This work calls for large-scale sequencing studies with robust HPV testing to improve the genomic understanding of PSCC. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35008677; info:eu-repo/semantics/altIdentifier/eissn/1422-0067; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_072A1559CF974; https://serval.unil.ch/notice/serval:BIB_072A1559CF97Test; urn:issn:1422-0067; https://serval.unil.ch/resource/serval:BIB_072A1559CF97.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_072A1559CF974Test |
| DOI: | 10.3390/ijms23010251 |
| الإتاحة: | https://doi.org/10.3390/ijms23010251Test https://serval.unil.ch/notice/serval:BIB_072A1559CF97Test https://serval.unil.ch/resource/serval:BIB_072A1559CF97.P001/REF.pdfTest http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_072A1559CF974Test |
| حقوق: | info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.31234603 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms23010251 |