دورية أكاديمية
Combining Mini-Mental State Examination and Montreal Cognitive Assessment for assessing the clinical efficacy of cholinesterase inhibitors in mild Alzheimer's disease: a pilot study
| العنوان: | Combining Mini-Mental State Examination and Montreal Cognitive Assessment for assessing the clinical efficacy of cholinesterase inhibitors in mild Alzheimer's disease: a pilot study |
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| المؤلفون: | Furneri, G, Varrasi, S, Guerrera, CS, Platania, GA, Torre, V, Boccaccio, FM, Testa, MF, Martelli, F, Privitera, A, Razza, G, Santagati, M, Di Nuovo, S, Pirrone, C, Castellano, S, Caraci, F, Monastero, R |
| المساهمون: | Furneri, G, Varrasi, S, Guerrera, CS, Platania, GA, Torre, V, Boccaccio, FM, Testa, MF, Martelli, F, Privitera, A, Razza, G, Santagati, M, Di Nuovo, S, Pirrone, C, Castellano, S, Caraci, F, Monastero, R |
| بيانات النشر: | SPRINGER IT |
| سنة النشر: | 2024 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | Cognitive decline, Alzheimer's Disease, MMSE, MoCA, Cholinesterase inhibitors, Psychometric tools, Settore MED/26 - Neurologia, Settore BIO/14 - Farmacologia, Settore M-PSI/03 - Psicometria, Settore M-PSI/01 - Psicologia Generale |
| الوصف: | Current drugs for Alzheimer's Disease (AD), such as cholinesterase inhibitors (ChEIs), exert only symptomatic activity. Different psychometric tools are needed to assess cognitive and non-cognitive dimensions during pharmacological treatment. In this pilot study, we monitored 33 mild-AD patients treated with ChEIs. Specifically, we evaluated the effects of 6 months (Group 1 = 17 patients) and 9 months (Group 2 = 16 patients) of ChEIs administration on cognition with the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), and the Frontal Assessment Battery (FAB), while depressive symptoms were measured with the Hamilton Depression Rating Scale (HDRS). After 6 months (Group 1), a significant decrease in MoCA performance was detected. After 9 months (Group 2), a significant decrease in MMSE, MoCA, and FAB performance was observed. ChEIs did not modify depressive symptoms. Overall, our data suggest MoCA is a potentially useful tool for evaluating the effectiveness of ChEIs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/38630416; info:eu-repo/semantics/altIdentifier/wos/WOS:001205148000003; volume:36; issue:1; firstpage:1; lastpage:5; numberofpages:5; journal:AGING CLINICAL AND EXPERIMENTAL RESEARCH; https://hdl.handle.net/10447/634917Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85190686341 |
| DOI: | 10.1007/s40520-024-02744-4 |
| الإتاحة: | https://doi.org/10.1007/s40520-024-02744-4Test https://hdl.handle.net/10447/634917Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4A6D5B3D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s40520-024-02744-4 |
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