دورية أكاديمية
Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia
| العنوان: | Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia |
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| المؤلفون: | Khan, Saira, Wolin, K. Y., Pakpahan, R., Grubb, R. L. III, Colditz, G. A., Ragard, L., Mabie, J., Breyer, B. N., Andriole, G. L., Sutcliffe, S. |
| بيانات النشر: | BMC Urology |
| سنة النشر: | 2021 |
| المجموعة: | The University of Delaware Library Institutional Repository |
| مصطلحات موضوعية: | Benign Prostatic Hyperplasia (BPH), body size, obesity, nocturia, prostate volume, PLCO, good health and well-being |
| الوصف: | This article was originally published in BMC Urology. The version of record is available at: https://doi.org/10.1186/s12894-021-00816-5Test ; Background Existing evidence suggests that there is an association between body size and prevalent Benign Prostatic Hyperplasia (BPH)-related outcomes and nocturia. However, there is limited evidence on the association between body size throughout the life-course and incident BPH-related outcomes. Methods Our study population consisted of men without histories of prostate cancer, BPH-related outcomes, or nocturia in the intervention arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) (n = 4710). Associations for body size in early- (age 20), mid- (age 50) and late-life (age ≥ 55, mean age 60.7 years) and weight change with incident BPH-related outcomes (including self-reported nocturia and physician diagnosis of BPH, digital rectal examination-estimated prostate volume ≥ 30 cc, and prostate-specific antigen [PSA] concentration > 1.4 ng/mL) were examined using Poisson regression with robust variance estimation. Results Men who were obese in late-life were 25% more likely to report nocturia (Relative Risk (RR): 1.25, 95% Confidence Interval (CI): 1.11–1.40; p-trendfor continuous BMI < 0.0001) and men who were either overweight or obese in late-life were more likely to report a prostate volume ≥ 30 cc (RRoverweight: 1.13, 95% CI 1.07–1.21; RRobese: 1.10, 95% CI 1.02–1.19; p-trendfor continuous BMI = 0.017) as compared to normal weight men. Obesity at ages 20 and 50 was similarly associated with both nocturia and prostate volume ≥ 30 cc. Considering trajectories of body size, men who were normal weight at age 20 and became overweight or obese by later-life had increased risks of nocturia (RRnormal to overweight: 1.09, 95% CI 0.98–1.22; RRnormal to obese: 1.28, 95% CI 1.10–1.47) and a prostate volume ≥ 30 cc (RRnormal to overweight: 1.12, 95% CI 1.05–1.20). Too few men were obese early in life to examine the independent effect of early-life body ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1471-2490 |
| العلاقة: | Khan, S., Wolin, K.Y., Pakpahan, R. et al. Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia. BMC Urol 21, 47 (2021). https://doi.org/10.1186/s12894-021-00816-5Test; https://udspace.udel.edu/handle/19716/33535Test |
| الإتاحة: | https://doi.org/10.1186/s12894-021-00816-5Test https://udspace.udel.edu/handle/19716/33535Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.D3128723 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712490 |
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