المؤلفون: Miller, Duncan C, Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy, Cook, Simon J, Edwards, Noel, Endicott, Jane A, Golding, Bernard T, Griffin, Roger J, Hardcastle, Ian, Harnor, Suzannah J, Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew P, Martin, Nick C, Myers, Stephanie, Newell, David R, Noble, Richard A, Phillips, Nicole, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie A, Wang, Lan-Zhen, Waring, Michael J, Wong, Ai-Ching, Wedge, Stephen R, Noble, Martin E, Cano, Celine

مصطلحات موضوعية: Chemistry

وصف الملف: application/pdf

العلاقة: http://sure.sunderland.ac.uk/id/eprint/14709/8/acs.jmedchem.1c01756.pdfTest; Miller, Duncan C , Reuillon, Tristan , Molyneux, Lauren , Blackburn, Timothy , Cook, Simon J , Edwards, Noel , Endicott, Jane A , Golding, Bernard T , Griffin, Roger J , Hardcastle, Ian , Harnor, Suzannah J , Heptinstall, Amy , Lochhead, Pamela , Martin, Mathew P , Martin, Nick C , Myers, Stephanie , Newell, David R , Noble, Richard A , Phillips, Nicole , Rigoreau, Laurent , Thomas, Huw , Tucker, Julie A , Wang, Lan-Zhen , Waring, Michael J , Wong, Ai-Ching , Wedge, Stephen R , Noble, Martin E and Cano, Celine (2022) Parallel Optimisation of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. Journal of Medicinal Chemistry, 65 (9). pp. 6513-6540. ISSN 0022-2623

الإتاحة: http://sure.sunderland.ac.uk/id/eprint/14709Test/
http://sure.sunderland.ac.uk/id/eprint/14709/8/acs.jmedchem.1c01756.pdfTest

المؤلفون: Anscombe, Elizabeth, Meschini, Elisa, Mora-Vidal, Regina, Martin, Mathew P., Staunton, David, Geitmann, Matthis, Danielson, U. Helena, Stanley, Will A., Wang, Lan Z., Reuillon, Tristan, Golding, Bernard T., Cano, Celine, Newell, David R., Noble, Martin E. M., Wedge, Stephen R., Endicott, Jane A., Griffin, Roger J.

المصدر: Chemistry and Biology. 22(9):1159-1164

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-268711Test
https://doi.org/10.1016Test/j.chembiol.2015.07.018
https://uu.diva-portal.org/smash/get/diva2:878807/FULLTEXT01.pdfTest

المؤلفون: Matheson, Christopher J., Coxon, Christopher R., Bayliss, Richard, Boxall, Kathy, Carbain, Benoit, Fry, Andrew M., Hardcastle, Ian R., Harnor, Suzannah J., Mas-Droux, Corine, Newell, David R., Richards, Mark W., Sivaprakasam, Mangaleswaran, Turner, David, Griffin, Roger J., Golding, Bernard T., Cano, Céline

المساهمون: Cancer Research UK

المصدر: RSC Medicinal Chemistry ; volume 11, issue 6, page 707-731 ; ISSN 2632-8682

الإتاحة: https://doi.org/10.1039/d0md00074dTest
http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00074DTest

المؤلفون: Willoughby, Catherine E., Jiang, Yanyan, Thomas, Huw D., Willmore, Elaine, Kyle, Suzanne, Wittner, Anita, Phillips, Nicole, Zhao, Yan, Tudhope, Susan J., Prendergast, Lisa, Junge, Gesa, Lourenco, Luiza Madia, Finlay, M. Raymond V., Turner, Paul, Munck, Joanne M., Griffin, Roger J., Rennison, Tommy, Pickles, James, Cano, Celine, Newell, Herbie, Reeves, Helen L., Ryan, Anderson J., Wedge, Stephen R.

وصف الملف: application/pdf

العلاقة: http://sure.sunderland.ac.uk/id/eprint/12742/1/Selective%20DNA-PKcs.pdfTest; Willoughby, Catherine E., Jiang, Yanyan, Thomas, Huw D., Willmore, Elaine, Kyle, Suzanne, Wittner, Anita, Phillips, Nicole, Zhao, Yan, Tudhope, Susan J., Prendergast, Lisa, Junge, Gesa, Lourenco, Luiza Madia, Finlay, M. Raymond V., Turner, Paul, Munck, Joanne M., Griffin, Roger J., Rennison, Tommy, Pickles, James, Cano, Celine, Newell, Herbie, Reeves, Helen L., Ryan, Anderson J. and Wedge, Stephen R. (2019) Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy. Journal of Clinical Investigation, 130 (1). pp. 258-271. ISSN 0021-9738

الإتاحة: https://doi.org/10.1172/JCI127483Test
http://sure.sunderland.ac.uk/id/eprint/12742Test/
http://sure.sunderland.ac.uk/id/eprint/12742/1/Selective%20DNA-PKcs.pdfTest

المؤلفون: Tucker, Julie Ann, Myers, Stephanie M., Miller, Duncan C., Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth H., Blackburn, Timothy J., Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Hardcastle, Ian R., Harnor, Suzannah J., Heptinstall, Amy B., Lochhead, Pamela A., Martin, Mathew P., Martin, Nick C., Newell, David R., Owen, Paul J., Pang, Leon C., Reuillon, Tristan, Rigoreau, Laurent J.M., Thomas, Huw D., Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin E.M., Wedge, Stephen R., Cano, Celine

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest; Tucker, Julie Ann orcid.org/0000-0002-6119-676X , Myers, Stephanie M., Miller, Duncan C. et al. (27 more authors) (2019) Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4. European Journal of Medicinal Chemistry. pp. 530-543. ISSN 0223-5234

الإتاحة: https://doi.org/10.1016Test/j.ejmech.2019.05.057
https://eprints.whiterose.ac.uk/148098Test/
https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest

المؤلفون: Tommasino, Chiara, Gambardella, Lucrezia, BUONCERVELLO, MARIA, Griffin, Roger J., Golding, Bernard T., Alberton, Manuela, Macchia, Daniele, Spada, Massimo, CERBELLI, BRUNA, D'AMATI, Giulia, Malorni, Walter, Gabriele, Lucia, Giammarioli, Anna Maria

المساهمون: Tommasino, Chiara, Gambardella, Lucrezia, Buoncervello, Maria, Griffin, Roger J., Golding, Bernard T., Alberton, Manuela, Macchia, Daniele, Spada, Massimo, Cerbelli, Bruna, D'Amati, Giulia, Malorni, Walter, Gabriele, Lucia, Giammarioli, Anna Maria

مصطلحات موضوعية: antifolate, antimalarial drug, apoptosi, chemotherapy, drug repurposing, melanoma, oncology, cancer research

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27599543; info:eu-repo/semantics/altIdentifier/wos/WOS:000385274900004; volume:35; issue:1; numberofpages:18; journal:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH; http://hdl.handle.net/11573/892296Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84986292276; http://www.jeccr.comTest/

الإتاحة: https://doi.org/10.1186/s13046-016-0409-9Test
http://hdl.handle.net/11573/892296Test
http://www.jeccr.comTest/

المؤلفون: Drummond, Catherine J, Esfandiari, Arman, Liu, Junfeng, Lu, Xiaohong, Hutton, Claire, Jackson, Jennifer, Bennaceur, Karim, Xu, Qing, Makimanejavali, Aditya Rao, DEL BELLO, FABIO, PIERGENTILI, Alessandro, Newell, David R, Hardcastle, Ian R, Griffin, Roger J, Lunec, John

المساهمون: Drummond, Catherine J, Esfandiari, Arman, Liu, Junfeng, Lu, Xiaohong, Hutton, Claire, Jackson, Jennifer, Bennaceur, Karim, Xu, Qing, Makimanejavali, Aditya Rao, DEL BELLO, Fabio, Piergentili, Alessandro, Newell, David R, Hardcastle, Ian R, Griffin, Roger J, Lunec, John

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000385402300104; volume:7; firstpage:46203; lastpage:46218; numberofpages:16; journal:ONCOTARGET; http://hdl.handle.net/11581/394236Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84979910691; http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&pathTest[]=10073&path[]=32713

الإتاحة: https://doi.org/10.18632/oncotarget.10073Test
http://hdl.handle.net/11581/394236Test
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&pathTest[]=10073&path[]=32713

المؤلفون: Mitcheson, Deborah F., Bottrill, Andrew R., Carr, Katherine, Coxon, Christopher R., Cano, Celine, Golding, Bernard T., Griffin, Roger J., Fry, Andrew M., Doerig, Christian, Bayliss, Richard, Tobin, Andrew B.

مصطلحات موضوعية: Chemical genetics, Covalent modification, Mass spectrometry, NIMA-related protein kinase (Nek), Plasmodium falciparum

العلاقة: https://www.ncbi.nlm.nih.gov/pubmed/27821169Test; Malaria Journal, 2016, 15:535; https://malariajournal.biomedcentral.com/articles/10.1186/s12936-016-1580-3Test; http://hdl.handle.net/2381/39786Test

الإتاحة: https://doi.org/10.1186/s12936-016-1580-3Test
http://hdl.handle.net/2381/39786Test

المؤلفون: Coxon, Christopher R., Anscombe, Elizabeth, Harnor, Suzannah J., Martin, Mathew P., Carbain, Benoit, Golding, Bernard T., Hardcastle, Ian R., Harlow, Lisa K., Korolchuk, Svitlana, Matheson, Christopher J., Newell, David R., Noble, Martin E. M., Sivaprakasam, Mangaleswaran, Tudhope, Susan J., Turner, David M., Wang, Lan Z., Wedge, Stephen R., Wong, Christopher, Griffin, Roger J., Endicott, Jane A., Cano, Céline

المساهمون: Medical Research Council, Cancer Research UK

المصدر: Journal of Medicinal Chemistry ; volume 60, issue 5, page 1746-1767 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.6b01254Test

المؤلفون: Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy J., Cook, Simon, Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian R., Heptinstall, Amy B., Lochhead, Pamela, Martin, Mathew P., Martin, Nick, Myers, Stephanie M., Newell, David R., Noble, Richard, Rigoreau, Laurent J.M., Thomas, Huw, Tucker, Julie Ann, Wang, Lan-Zhen, Waring, Michael J., Wong, Ai-Ching, Wedge, Stephen, Noble, Martin, Cano, Celine

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::643876374a98b92971005d5d769a4162Test
https://eprints.whiterose.ac.uk/185363/3/acs.jmedchem.1c01756.pdfTest