المؤلفون: Ochaba, Joseph, Powers, Andrew F, Tremble, Kaitlyn A, Greenlee, Sarah, Post, Noah M, Matson, John E, MacLeod, A Robert, Guo, Shuling, Aghajan, Mariam

المساهمون: Ionis Pharmaceuticals

المصدر: Nucleic Acids Research ; volume 47, issue 21, page 11284-11303 ; ISSN 0305-1048 1362-4962

مصطلحات موضوعية: Genetics

الإتاحة: https://doi.org/10.1093/nar/gkz901Test
http://academic.oup.com/nar/article-pdf/47/21/11284/31074561/gkz901.pdfTest

المؤلفون: Narayanan, Padmakumar, Shen, Lijiang, Curtis, Brian R, Bourdon, Mario A, Nolan, John P, Gupta, Shipra, Hoffmaster, Christine, Zhou, Fangli, Christian, Bryan, Schaubhut, Jayne L, Greenlee, Sarah, Burel, Sebastien A, Witztum, Joe L, Engelhardt, Jeffrey A, Henry, Scott P

المساهمون: Ionis Pharmaceuticals

المصدر: Toxicological Sciences ; volume 164, issue 2, page 613-626 ; ISSN 1096-6080 1096-0929

مصطلحات موضوعية: Toxicology

الإتاحة: https://doi.org/10.1093/toxsci/kfy119Test
http://academic.oup.com/toxsci/article-pdf/164/2/613/25222376/kfy119.pdfTest

المؤلفون: Khojasteh, S Cyrus, Argikar, Upendra A, Driscoll, James P, Heck, Carley JS, King, Lloyd, Jackson, Klarissa D, Jian, Wenying, Kalgutkar, Amit S, Miller, Grover P, Kramlinger, Valerie, Rietjens, Ivonne MCM, Teitelbaum, Aaron M, Wang, Kai, Wei, Cong, Johnson, Benjamin M, Shu, Yue-Zhong, Zhuo, Xiaoliang, Meanwell, Nicholas A, Cerny, Matthew A, Obach, R Scott, Sharma, Raman, Spracklin, Douglas K, Walker, Gregory S, Goracci, Laura, Desantis, Jenny, Valeri, Aurora, Castellani, Beatrice, Eleuteri, Michela, Cruciani, Gabriele, Lall, Manjinder S, Bassyouni, Asser, Bradow, James, Brown, Maria, Bundesmann, Mark, Chen, Jinshan, Ciszewski, Gregory, Hagen, Anne E, Hyek, Dennis, Jenkinson, Stephen, Liu, Bo, Pan, Senliang, Reilly, Usa, Sach, Neal, Smaltz, Daniel J, Starr, Jeremy, Wagenaar, Melissa, de Bruyn Kops, Christina, Sicho, Martin, Mazzolari, Angelica, Kirchmair, Johannes, Korprasertthaworn, Porntipa, Chau, Nuy, Nair, Pramod C, Rowland, Andrew, Miners, John O, Wrobleski, Stephen T, Moslin, Ryan, Lin, Shuqun, Zhang, Yanlei, Spergel, Steven, Kempson, James, Tokarski, John S, Strnad, Joann, Zupa-Fernandez, Adriana, Cheng, Lihong, Shuster, David, Gillooly, Kathleen, Yang, Xiaoxia, Heimrich, Elizabeth, McIntyre, Kim W, Chaudhry, Charu, Khan, Javed, Ruzanov, Max, Tredup, Jeffrey, Mulligan, Dawn, Xie, Dianlin, Sun, Huadong, Huang, Christine, D'Arienzo, Celia, Aranibar, Nelly, Chiney, Manoj, Chimalakonda, Anjaneya, Pitts, William J, Lombardo, Louis, Carter, Percy H, Burke, James R, Weinstein, David S, Li, Jing, Liu, Ju, Enders, Jennifer, Arciprete, Michael, Tran, Chris, Aluri, Krishna, Guan, Li-Hua, O'Shea, Jonathan, Bisbe, Anna, Charisse, Klaus, Zlatev, Ivan, Najarian, Diana, Xu, Yuanxin, Kim, Jaeah, El Zahar, Noha M, Bartlett, Michael G, Katyayan, Kishore, Yi, Ping, Monk, Scott, Cassidy, Kenneth, Takahashi, Ryan H, Grandner, Jessica M, Bobba, Sudheer, Liu, Yanzhou, Beroza, Paul, Zhang, Donglu, Ma, Shuguang, Post, Noah, Yu, Rosie, Greenlee, Sarah, Gaus, Hans, Hurh, Eunju, Matson, John, Wang, Yanfeng, Tajima, Yuya, Toyoda, Takeshi, Hirayama, Yuichiro, Matsushita, Kohei, Yamada, Takanori, Ogawa, Kumiko, Watanabe, Kenji, Takamura-Enya, Takeji, Totsuka, Yukari, Wakabayashi, Keiji, Miyoshi, Noriyuki, Zhang, Jiayin, Chan, Chi-Kong, Ham, Yat-Hing, Chan, Wan, Schleiff, Mary Alexandra, Flynn, Noah R, Payakachat, Sasin, Schleiff, Benjamin Mark, Pinson, Anna O, Province, Dennis W, Swamidass, S Joshua, Boysen, Gunnar, Nardone-White, Dasean T, Bissada, Jennifer E, Abouda, Arsany A, Zhang, Zhuming, Connolly, Peter J, Lim, Heng Keang, Pande, Vineet, Meerpoel, Lieven, Teleha, Christopher, Branch, Jonathan R, Ondrus, Janine, Hickson, Ian, Bush, Tammy, Luistro, Leopoldo, Packman, Kathryn, Bischoff, James R, Ibrahim, Salam, Parrett, Christopher, Chong, Yolanda, Gottardis, Marco M, Bignan, Gilles, Mulder, Teresa, Bobba, Sudder, Johnson, Kevin M, Wang, Wei, Zhang, Chenghong, Cai, Jingwei, Choo, Edna F, Crawford, James J, Landry, Matthew L, Chen, Huifen, Kenny, Jane R, Lee, Wendy, Young, Wendy B, Geib, Timon, Thulasingam, Madhuranayaki, Haeggstrom, Jesper Z, Sleno, Lekha, Monroe, James J, Tanis, Keith Q, Podtelezhnikov, Alexei A, Nguyen, Truyen, Machotka, Sam V, Lynch, Donna, Evers, Raymond, Palamanda, Jairam, Miller, Randy R, Pippert, Todd, Cabalu, Tamara D, Johnson, Timothy E, Aslamkhan, Amy G, Kang, Wen, Tamburino, Alex M, Mitra, Kaushik, Agrawal, Nancy GB, Sistare, Frank D

المصدر: Drug Metabolism Reviews 53 (2021) 3
Drug Metabolism Reviews, 53(3), 384-433

مصطلحات موضوعية: METABOLISM, Toxicology, 030226 pharmacology & pharmacy, 03 medical and health sciences, nonp450 enzymes, 0302 clinical medicine, p450 enzymes, Biotransformation, INTRINSIC CLEARANCE, Political science, MASS-BALANCE, Humans, Pharmacology (medical), Pharmacology & Pharmacy, P450 Enzymes, General Pharmacology, Toxicology and Pharmaceutics, ANTISENSE OLIGONUCLEOTIDE, Toxicologie, VLAG, ARISTOLOCHIC ACID, Drug metabolism, Science & Technology, WIMEK, bioactivation, IDENTIFICATION, Year in review, IN-VITRO, NONHEPATOTOXIC DRUGS, Drug metabolizing enzymes, Drug development, 030220 oncology & carcinogenesis, COVALENT BINDING DATA, Engineering ethics, biotransformation, LIVER-MICROSOMES, Life Sciences & Biomedicine

وصف الملف: application/pdf; Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a22a3073b1b8be7c5621703d8a65f67Test
https://doi.org/10.1080/03602532.2021.1916028Test

المؤلفون: Tasfaout, Hichem, Buono, Suzie, Guo, Shuling, Kretz, Christine, Messaddeq, Nadia, Booten, Sheri, Greenlee, Sarah, Monia, Brett P., Cowling, Belinda S., Laporte, Jocelyn

المصدر: Nature Communications ; volume 8, issue 1 ; ISSN 2041-1723

مصطلحات موضوعية: General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary

الإتاحة: https://doi.org/10.1038/ncomms15661Test
https://www.nature.com/articles/ncomms15661.pdfTest
https://www.nature.com/articles/ncomms15661Test

المؤلفون: Crosby, Jeff R., Zhao, Chenguang, Jiang, Chong, Bai, Dong, Katz, Melanie, Greenlee, Sarah, Kawabe, Hiroshi, McCaleb, Michael, Rotin, Daniela, Guo, Shuling, Monia, Brett P.

المساهمون: Ionis Pharmaceuticals, Inc

المصدر: Journal of Cystic Fibrosis ; volume 16, issue 6, page 671-680 ; ISSN 1569-1993

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1016/j.jcf.2017.05.003Test
https://api.elsevier.com/content/article/PII:S1569199317301546?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1569199317301546?httpAccept=text/plainTest

المؤلفون: Shemesh, Colby S, Yu, Rosie Z, Gaus, Hans J, Greenlee, Sarah, Post, Noah, Schmidt, Karsten, Migawa, Michael T, Seth, Punit P, Zanardi, Thomas A, Prakash, Thazha P, Swayze, Eric E, Henry, Scott P, Wang, Yanfeng

المصدر: Molecular Therapy - Nucleic Acids ; volume 5, page e319 ; ISSN 2162-2531

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

الإتاحة: https://doi.org/10.1038/mtna.2016.31Test
https://api.elsevier.com/content/article/PII:S216225311730046X?httpAccept=text/plainTest
https://api.elsevier.com/content/article/PII:S216225311730046X?httpAccept=text/xmlTest

المؤلفون: Carroll, Jeffrey B, Warby, Simon C, Southwell, Amber L, Doty, Crystal N, Greenlee, Sarah, Skotte, Niels, Hung, Gene, Bennett, C Frank, Freier, Susan M, Hayden, Michael R

المصدر: Carroll , J B , Warby , S C , Southwell , A L , Doty , C N , Greenlee , S , Skotte , N , Hung , G , Bennett , C F , Freier , S M & Hayden , M R 2011 , ' Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin ' , Molecular therapy : the journal of the American Society of Gene Therapy , vol. 19 , no. 12 , pp. 2178-85 . https://doi.org/10.1038/mt.2011.201Test

مصطلحات موضوعية: Alleles, Animals, Brain, Cells, Cultured, Female, Fibroblasts, Gene Silencing, Genetic Therapy, Humans, Huntingtin Protein, Huntington Disease, Male, Mice, Transgenic, Mutant Proteins, Nerve Tissue Proteins, Neurons, Nuclear Proteins, Oligonucleotides, Antisense, Pedigree, Polymorphism, Single Nucleotide, RNA, Messenger, Serotonin Plasma Membrane Transport Proteins, Trinucleotide Repeat Expansion, Journal Article, Research Support

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1038/mt.2011.201Test
https://curis.ku.dk/portal/da/publications/potent-and-selective-antisense-oligonucleotides-targeting-singlenucleotide-polymorphisms-in-the-huntington-disease-gene--allelespecific-silencing-of-mutant-huntingtinTest(2ff3a7fc-a2c3-4597-a0f4-05194ce1fe62).html
https://curis.ku.dk/ws/files/190863894/1_s2.0_S1525001616327034_main.pdfTest

المؤلفون: Wang, Susanna S., Shi, Weibin, Wang, Xuping, Velky, Leandra, Greenlee, Sarah, Wang, Min T., Drake, Thomas A., Lusis, Aldons J.

المصدر: Arteriosclerosis, Thrombosis, and Vascular Biology ; volume 27, issue 12, page 2671-2676 ; ISSN 1079-5642 1524-4636

الإتاحة: https://doi.org/10.1161/atvbaha.107.148106Test

المؤلفون: Shen, Wen, De Hoyos, Cheryl L., Migawa, Michael T., Vickers, Timothy A., Sun, Hong, Low, Audrey, Bell, Thomas A., Rahdar, Meghdad, Mukhopadhyay, Swagatam, Hart, Christopher E., Bell, Melanie, Riney, Stan, Murray, Susan F., Greenlee, Sarah, Crooke, Rosanne M., Liang, Xue-hai, Seth, Punit P., Crooke, Stanley T.

المصدر: Nature Biotechnology ; volume 37, issue 6, page 640-650 ; ISSN 1087-0156 1546-1696

مصطلحات موضوعية: Biomedical Engineering, Molecular Medicine, Applied Microbiology and Biotechnology, Bioengineering, Biotechnology

الإتاحة: https://doi.org/10.1038/s41587-019-0106-2Test
http://www.nature.com/articles/s41587-019-0106-2.pdfTest
http://www.nature.com/articles/s41587-019-0106-2Test