Prothrombogenic factors and reduced antioxidative defense in children and adolescents with pre-metabolic and metabolic syndrome
| العنوان: | Prothrombogenic factors and reduced antioxidative defense in children and adolescents with pre-metabolic and metabolic syndrome |
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| المؤلفون: | Fadil Canovic, Tanja Nisic, Gordana Pejcic, Gordana Milic, D.M. Nikolic, Vladan Vukcevic, Miroljub Ilic, Vesna Dimitrijevic-Sreckovic, Predrag Djordjevic, Radmila Obrenovic, Emina Colak, Srdjan Popovic, Branko Sreckovic, Drasko Gostiljac |
| المصدر: | Clinical Chemical Laboratory Medicine. 45 |
| بيانات النشر: | Walter de Gruyter GmbH, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Clinical Biochemistry, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Biology, Models, Biological, Antioxidants, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Hyperinsulinism, Internal medicine, Insulin Secretion, Plasminogen Activator Inhibitor 1, medicine, Humans, Insulin, Obesity, Child, Abdominal obesity, Metabolic Syndrome, 2. Zero hunger, chemistry.chemical_classification, Glucose tolerance test, medicine.diagnostic_test, Glutathione peroxidase, Biochemistry (medical), General Medicine, Glucose Tolerance Test, medicine.disease, Lipids, 3. Good health, Endocrinology, chemistry, Female, Insulin Resistance, medicine.symptom, Metabolic syndrome |
| الوصف: | Background: The aim of this study was to examine prothrombogenic factors and antioxidative defense in obese children and adolescents with pre-metabolic and metabolic syndrome, and to analyze insulin secretion and resistance, early glycoregulation disorders and lipid status. Methods: Insulin sensitivity was determined using the homeostasis model assessment for insulin resistance (HOMA-IR), while insulin secretion was determined using the homeostasis model assessment (HOMA-β). Prothrombogenic factors analyzed were plasma plasminogen activator inhibitor-1 (PAI-1) and fibrinogen. Superoxide dismutase and glutathione peroxidase were measured as markers of antioxidative defense. Results: Patients with metabolic syndrome were characterized with increased body mass index (BMI), waist circumference, and HOMA-IR and HOMA-β levels, and all had increased blood pressure and triglyceride levels, low high-density lipoprotein cholesterol levels, increased PAI-1 levels and reduced antioxidative defense levels. Patients with pre-metabolic syndrome had higher levels of basal and mean insulinemia during an oral glucose tolerance test, higher levels of HOMA-β and lower levels of antioxidative defense compared to patients with metabolic syndrome. Conclusions: Negative correlations between antioxidative defense parameters and BMI, abdominal obesity, insulin secretion, systolic blood pressure and atherogenic lipid factors, as well as correlations between PAI-1 and insulin resistance and basal glycemia in the metabolic syndrome group contribute to accelerated atherosclerosis. Positive correlations between PAI-1 and waist circumference and BMI, and negative correlations between BMI and antioxidative defense in the pre-metabolic syndrome patients show that this early stage preceding the metabolic syndrome is also characterized by atherosclerotic complication risks and evident hyperinsulinism and insulin resistance. |
| تدمد: | 1437-4331 1434-6621 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958ec673fb2c0c513f7538c639cb3102Test https://doi.org/10.1515/cclm.2007.259Test |
| رقم الانضمام: | edsair.doi.dedup.....958ec673fb2c0c513f7538c639cb3102 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374331 14346621 |
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