المؤلفون: Chandra, Vikash, Ibrahim, Hazem, Halliez, Clémentine, Prasad, Rashmi B, Vecchio, Federica, Dwivedi, Om Prakash, Kvist, Jouni, Balboa, Diego, Saarimäki-Vire, Jonna, Montaser, Hossam, Barsby, Tom, Lithovius, Väinö, Artner, Isabella, Gopalakrishnan, Swetha, Groop, Leif, Mallone, Roberto, Eizirik, Decio L, Otonkoski, Timo

المصدر: Nature Communications EXODIAB: Excellence of Diabetes Research in Sweden StemTherapy: National Initiative on Stem Cells for Regenerative Therapy. 13(1)

مصطلحات موضوعية: Humans, Interferon-alpha/pharmacology, Diabetes Mellitus, Type 1/genetics, TYK2 Kinase/genetics, Proto-Oncogene Proteins p21(ras)/metabolism, Insulins/metabolism, Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes

الوصول الحر: https://lup.lub.lu.se/record/157c8aea-383a-426b-827e-946b87618fd9Test
http://dx.doi.org/10.1038/s41467-022-34069-zTest

المؤلفون: Lapatto, Helena A. K., Kuusela, Minna, Heikkinen, Aino, Muniandy, Maheswary, van der Kolk, Birgitta W., Gopalakrishnan, Swetha, Pöllänen, Noora, Sandvik, Martin, Schmidt, Mark S., Heinonen, Sini, Saari, Sina, Kuula, Juho, Hakkarainen, Antti, Tampio, Janne, Saarinen, Tuure, Taskinen, Marja-Riitta, Lundbom, Nina, Groop, Per-Henrik, Tiirola, Marja, Katajisto, Pekka, Lehtonen, Marko, Brenner, Charles, Kaprio, Jaakko, Pekkala, Satu, Ollikainen, Miina, Pietiläinen, Kirsi H., Pirinen, Eija

المساهمون: Centre of Excellence in Stem Cell Metabolism, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Molecular and Integrative Biosciences Research Programme, Institute of Biotechnology, HUS Medical Imaging Center, Clinicum, HUS Abdominal Center, II kirurgian klinikka, Marja-Riitta Taskinen Research Group, Research Programs Unit, Department of Medicine, Per Henrik Groop / Principal Investigator, Medicum, Nefrologian yksikkö, Department of Biochemistry and Developmental Biology, Eija Pirinen / Principal Investigator

مصطلحات موضوعية: High-fat diet, Dna methylation, Skeletal-muscle, Adipose-tissue, Faecalibacterium-prausnitzii, Nad(+), Metabolism, Niacin, Liver, Supplementation, 3111 Biomedicine, 11832 Microbiology and virology

وصف الملف: application/pdf

العلاقة: Lapatto , H A K , Kuusela , M , Heikkinen , A , Muniandy , M , van der Kolk , B W , Gopalakrishnan , S , Pöllänen , N , Sandvik , M , Schmidt , M S , Heinonen , S , Saari , S , Kuula , J , Hakkarainen , A , Tampio , J , Saarinen , T , Taskinen , M-R , Lundbom , N , Groop , P-H , Tiirola , M , Katajisto , P , Lehtonen , M , Brenner , C , Kaprio , J , Pekkala , S , Ollikainen , M , Pietiläinen , K H & Pirinen , E 2023 , ' Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study ' , Science Advances , vol. 9 , no. 2 , eadd5163 . https://doi.org/10.1126/sciadv.add5163Test; ORCID: /0000-0002-6229-3588/work/127503841; ORCID: /0000-0003-3661-7400/work/127504093; ORCID: /0000-0002-5793-9196/work/127508370; ORCID: /0000-0001-8608-541X/work/127508859; ORCID: /0000-0003-2013-4420/work/128032715; ORCID: /0000-0002-3295-1260/work/133998104; 714d22d2-aa5a-4407-aee4-456b3290c766; http://hdl.handle.net/10138/353809Test; 000911464300022

الإتاحة: http://hdl.handle.net/10138/353809Test

المؤلفون: Chandra, Vikash, Rachdi, Latif, Gopalakrishnan, Swetha

المصدر: Frontiers in Endocrinology ; volume 14 ; ISSN 1664-2392

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism

الإتاحة: https://doi.org/10.3389/fendo.2023.1175213Test

المؤلفون: Chandra, Vikash, Ibrahim, Hazem, Halliez, Clementine, Prasad, Rashmi B., Vecchio, Federica, Dwivedi, Om Prakash, Kvist, Jouni, Balboa, Diego, Saarimäki-Vire, Jonna, Montaser, Hossam, Barsby, Tom, Lithovius, Väinö, Artner, Isabella, Gopalakrishnan, Swetha, Groop, Leif, Mallone, Roberto, Eizirik, Decio L., Otonkoski, Timo

المساهمون: Research Programs Unit, Faculty Common Matters (Faculty of Medicine), STEMM - Stem Cells and Metabolism Research Program, Centre of Excellence in Stem Cell Metabolism, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Institute of Biotechnology, Clinicum, Centre of Excellence in Complex Disease Genetics, Leif Groop Research Group, HUS Abdominal Center, Children's Hospital, Helsinki One Health (HOH), HUS Children and Adolescents

مصطلحات موضوعية: ENDOCRINE DIFFERENTIATION, R-PACKAGE, EXPRESSION, APOPTOSIS, Biomedicine, Genetics, developmental biology, physiology

وصف الملف: application/pdf

العلاقة: We gratefully acknowledge Dr. Fatoumata Samassa for help with cytotoxicity assays. We thank Jarkko Ustinov for the insulin and c-peptide ELISA measurements. S. Eurola, H. Grym, and A. Laitinen are thanked for expert technical support. We thank FIMM Single Cell Analytics unit (supported by HiLIFE and Biocentre Finland) for single cell RNA sequencing services. We want to acknowledge the participants and investigators of the FinnGen study. T.O. acknowledges the funding provided by the Academy of Finland (MetaStem Center of Excellence grant 312437), the Novo Nordisk Foundation and the Sigrid Juselius Foundation. R.M. acknowledges the support of the Agence Nationale de la Recherche (ANR-19-CE15-0014-01) and the Fondation pour la Recherche Medicale (EQU20193007831). C.H. was funded by an Annee Recherche fellowship of the Paris Saclay University. F.V. was funded by an international PhD fellowship of the IdEx Universite de Paris. R.B.P. acknowledges the funding by Hjelt foundation, Crafoord foundation (2020089) and Swedish Research Council (2021-02623). D.L.E. acknowledges the support of grants from the Welbio-FNRS (Fonds National de la Recherche Scientifique; WELBIO-CR-2019C-04), Belgium; the Innovate2CureType1-Dutch Diabetes Research Foundation (DDRF), Holland; the Juvenile Diabetes Foundation (JDRF; 2-SRA-2019-834-S-B); the NIH (HIRN-CBDS) grant U01 DK127786, USA. D.L.E., T.O., and R.M. acknowledge support from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreements No 115797 (INNODIA) and 945268 (INNODIA HARVEST), supported by the European Union's Horizon 2020 research and innovation programme. These Joint Undertakings receive support from the Union's Horizon 2020 research and innovation programme and "EFPIA", "JDRF" and "The Leona M. and Harry B. Helmsley Charitable Trust".; Chandra , V , Ibrahim , H , Halliez , C , Prasad , R B , Vecchio , F , Dwivedi , O P , Kvist , J , Balboa , D , Saarimäki-Vire , J , Montaser , H , Barsby , T , Lithovius , V , Artner , I , Gopalakrishnan , S , Groop , L , Mallone , R , Eizirik , D L & Otonkoski , T 2022 , ' The type 1 diabetes gene TYK2 regulates beta-cell development and its responses to interferon-alpha ' , Nature Communications , vol. 13 , no. 1 , 6363 . https://doi.org/10.1038/s41467-022-34069-zTest; ORCID: /0000-0002-1537-5548/work/124031042; ORCID: /0000-0003-0879-1807/work/124032742; ORCID: /0000-0002-8865-7060/work/159903877; http://hdl.handle.net/10138/351275Test; 153b8869-6a4d-428d-8808-494b333d6cae; 000874935700004

الإتاحة: http://hdl.handle.net/10138/351275Test

المؤلفون: Chandra, Vikash, Rachdi, Latif, Gopalakrishnan, Swetha

المساهمون: Research Programs Unit, Faculty Common Matters (Faculty of Medicine), STEMM - Stem Cells and Metabolism Research Program, Centre of Excellence in Stem Cell Metabolism, Molecular and Integrative Biosciences Research Programme, Institute of Biotechnology

مصطلحات موضوعية: T1D autoimmunity, T1D mouse model, Pancreatic beta (beta) cells, Stem cell modeling, Type 1 diabetes, 1182 Biochemistry, cell and molecular biology, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: Chandra , V , Rachdi , L & Gopalakrishnan , S 2023 , ' Revisiting cellular metabolism and type 1 diabetes ' , Frontiers in Endocrinology , vol. 14 , 1175213 . https://doi.org/10.3389/fendo.2023.1175213Test; af8f128c-bd24-4ac8-b823-89503b5f004e; http://hdl.handle.net/10138/358343Test; 000990801100001

الإتاحة: http://hdl.handle.net/10138/358343Test

المؤلفون: Pentinmikko, Nalle, Iqbal, Sharif, Mana, Miyeko, Andersson, Simon, Cognetta, Armand B., Suciu, Radu M., Roper, Jatin, Luopajärvi, Kalle, Markelin, Eino, Gopalakrishnan, Swetha, Smolander, Olli-Pekka, Naranjo, Santiago, Saarinen, Tuure, Juuti, Anne, Pietiläinen, Kirsi, Auvinen, Petri, Ristimäki, Ari, Gupta, Nitin, Tammela, Tuomas, Jacks, Tyler, Sabatini, David M., Cravatt, Benjamin F., Yilmaz, Omer H., Katajisto, Pekka

المساهمون: Helsinki Institute of Life Science HiLIFE, Joint Activities, Centre of Excellence in Stem Cell Metabolism, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, University of Helsinki, HUS Abdominal Center, Research Programs Unit, Diabetes and Obesity Research Program, II kirurgian klinikka, Department of Surgery, Department of Medicine, University Management, DNA Sequencing and Genomics, Department of Pathology, HUSLAB, Gastrointestinal tumorigenesis, Medicum, Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences

مصطلحات موضوعية: STEM-CELLS, COLORECTAL-CANCER, LIFE-SPAN, ACID, IDENTIFICATION, ACTIVATION, KNOCKOUT, COLON, 3111 Biomedicine, 3121 General medicine, internal medicine and other clinical medicine, 3126 Surgery, anesthesiology, intensive care, radiology

وصف الملف: application/pdf

العلاقة: This study was supported by the Academy of Finland (Research Fellow and Centre of Excellence, MetaStem), Marie Curie CIG (618774), ERC-STG (677809), Swedish Research Council 2018-03078, Sigrid Juselius Foundation, Center for Innovative Medicine, and Wallenberg Academy Fellows program to P.K. N.P. was supported by the Integrative Life Science Doctoral program and by the Research foundation of University of Helsinki. B.F.C. was supported by grant R35 CA231991. We thank the personnel of the DNA sequencing and genomics laboratory for performing the RNA sequencing assays. We thank J. Barlund, A. Sola-Carvajal, M. Simula and A. Kegel for technical assistance.; Pentinmikko , N , Iqbal , S , Mana , M , Andersson , S , Cognetta , A B , Suciu , R M , Roper , J , Luopajärvi , K , Markelin , E , Gopalakrishnan , S , Smolander , O-P , Naranjo , S , Saarinen , T , Juuti , A , Pietiläinen , K , Auvinen , P , Ristimäki , A , Gupta , N , Tammela , T , Jacks , T , Sabatini , D M , Cravatt , B F , Yilmaz , O H & Katajisto , P 2019 , ' Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium ' , Nature , vol. 571 , no. 7765 , pp. 398-+ . https://doi.org/10.1038/s41586-019-1383-0Test; e1104302-b1a0-4e45-8081-6fe665c92659; http://hdl.handle.net/10138/318793Test; 000475851900036

الإتاحة: http://hdl.handle.net/10138/318793Test

المؤلفون: Gopalakrishnan, Swetha, Kannan, Nisha N

المساهمون: The Wellcome Trust DBT India Alliance

المصدر: Chronobiology International ; volume 38, issue 2, page 149-167 ; ISSN 0742-0528 1525-6073

الإتاحة: https://doi.org/10.1080/07420528.2020.1842436Test

المؤلفون: Comai, Glenda, Heude, Eglantine, Mella, Sebastian, Paisant, Sylvain, Pala, Francesca, Gallardo, Mirialys, Langa, Francina, Kardon, Gabrielle, Gopalakrishnan, Swetha, Tajbakhsh, Shahragim

المساهمون: Centre of Excellence in Stem Cell Metabolism, Institute of Biotechnology

مصطلحات موضوعية: C-MET RECEPTOR, GROWTH-FACTOR, MOUSE ESOPHAGUS, SKELETAL MYOGENESIS, PROGENITOR CELLS, PHARYNGEAL ARCH, EXPRESSION, REVEALS, HEAD, DIFFERENTIATION, 1184 Genetics, developmental biology, physiology

وصف الملف: application/pdf

العلاقة: NIH Office of the Director R01 HD087360 Mirialys Gallardo Gabrielle Kardon; Comai , G , Heude , E , Mella , S , Paisant , S , Pala , F , Gallardo , M , Langa , F , Kardon , G , Gopalakrishnan , S & Tajbakhsh , S 2019 , ' A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle ' , eLife , vol. 8 , 47460 . https://doi.org/10.7554/eLife.47460Test; 2aceae48-9513-4aa8-83e3-047172e7cdc3; http://hdl.handle.net/10138/306777Test; 000487717300001

الإتاحة: http://hdl.handle.net/10138/306777Test

المؤلفون: Tabler, Jacqueline, Rigney, Maggie, Berman, Gordon, Gopalakrishnan, Swetha, Heude, Eglantine, Al-Lami, Hadeel Adel, Yannakoudakis, Basil, Fitch, Rebecca, Carter, Christopher, Vokes, Steven, Liu, Karen, Tajbakhsh, Shahragim, Egnor, S.E Roian, Wallingford, John

المساهمون: Department of Molecular Biosciences Austin, TX, USA, University of Texas at Austin Austin, Department of Biology Atlanta, GA, USA, Emory University Atlanta, GA, Cellules Souches et Développement / Stem Cells and Development, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Département Adaptations du vivant (AVIV), Muséum national d'Histoire naturelle (MNHN), Department of Craniofacial Development and Stem Cell Biology London, UK, King‘s College London, Janelia Farm Research Campus, Howard Hughes Medical Institute (HHMI), This work was supported by an NRSA to JT from the NIDCR (F32DE023272), funding to ST from the Institut Pasteur, Association Française contre le Myopathies, and Agence Nationale de la Recherche (Laboratoire d’Excellence Revive, Investissement d’Avenir, ANR-10-LABX-73), and NIH R01HD073151 to SAV and R01HD085901 to JBW SERE is supported by the Howard Hughes Medical Institute, JBW was once an early career scientist of the HHMI., ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010)

المصدر: EISSN: 2050-084X ; eLife ; https://mnhn.hal.science/mnhn-02295443Test ; eLife, 2017, 6, pp.e19153. ⟨10.7554/eLife.19153⟩

مصطلحات موضوعية: CPLANE, Fuz, cilia, ciliopathy, developmental biology, larynx, mouse, neural crest, stem cells, [SDV.BA]Life Sciences [q-bio]/Animal biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, [SDV.BDD]Life Sciences [q-bio]/Development Biology, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], [SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28177282; mnhn-02295443; https://mnhn.hal.science/mnhn-02295443Test; https://mnhn.hal.science/mnhn-02295443/documentTest; https://mnhn.hal.science/mnhn-02295443/file/elife-19153-v4.pdfTest; PUBMED: 28177282; PUBMEDCENTRAL: PMC5358977

الإتاحة: https://doi.org/10.7554/eLife.19153Test
https://mnhn.hal.science/mnhn-02295443Test
https://mnhn.hal.science/mnhn-02295443/documentTest
https://mnhn.hal.science/mnhn-02295443/file/elife-19153-v4.pdfTest

المؤلفون: Döhla, Julia, Kuuluvainen, Emilia, Gebert, Nadja, Amaral, Ana, Englund, Johanna I., Gopalakrishnan, Swetha, Konovalova, Svetlana, Nieminen, Anni I., Salminen, Ella S., Torregrosa Muñumer, Rubén, Ahlqvist, Kati, Yang, Yang, Bui, Hien, Otonkoski, Timo, Käkelä, Reijo, Hietakangas, Ville, Tyynismaa, Henna, Ori, Alessandro, Katajisto, Pekka

المصدر: Nature Cell Biology ; volume 24, issue 2, page 148-154 ; ISSN 1465-7392 1476-4679

مصطلحات موضوعية: Cell Biology

الإتاحة: https://doi.org/10.1038/s41556-021-00837-0Test
https://www.nature.com/articles/s41556-021-00837-0.pdfTest
https://www.nature.com/articles/s41556-021-00837-0Test