Nucleation and dynamics of Golgi-derived microtubules
| العنوان: | Nucleation and dynamics of Golgi-derived microtubules |
|---|---|
| المؤلفون: | Irina Kaverina, Anna A. W. M. Sanders |
| المصدر: | Frontiers in Neuroscience, Vol 9 (2015) Frontiers in Neuroscience |
| بيانات النشر: | Frontiers Media S.A., 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | γ-TuRC, Mini Review, microtubule nucleation, Golgi Apparatus, Biology, Bioinformatics, Clasps, Microtubules, lcsh:RC321-571, 03 medical and health sciences, symbols.namesake, CLASP1, 0302 clinical medicine, Microtubule, Golgi-derived microtubules, Cell polarity, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, 030304 developmental biology, Microtubule nucleation, Psychiatry, 0303 health sciences, Golgi membrane, General Neuroscience, Microtubule organizing center, Golgi apparatus, microtubule dynamics, CLASP, Cell biology, Centrosome, symbols, 030217 neurology & neurosurgery, CLASP2 |
| الوصف: | Integrity of the Golgi apparatus requires the microtubule (MT) network. A subset of MTs originates at the Golgi itself, which in this case functions as a MT-organizing center (MTOC). Golgi-derived MTs serve important roles in post-Golgi trafficking, maintenance of Golgi integrity, cell polarity and motility, as well as cell type-specific functions, including neurite outgrowth/branching. Here, we discuss possible models describing the formation and dynamics of Golgi-derived MTs. How Golgi-derived MTs are formed is not fully understood. A widely discussed model implicates that the critical step of the process is recruitment of mo-lecular factors, which drive MT nucleation (γ-tubulin ring complex, or γ-TuRC), to the Golgi membrane via specific scaffolding interactions. Based on recent findings, we propose to introduce an additional level of regulation, whereby MT-binding proteins and/or local tubulin dimer concentration at the Golgi helps to overcome kinetic barriers at the initial nucleation step. According to our model, emerging MTs are subsequently stabilized by Golgi-associated MT-stabilizing proteins. We discuss molecular factors potentially involved in all three steps of MT formation. To preserve proper cell functioning, a balance must be maintained between MT subsets at the centrosome and the Golgi. Recent work has shown that certain centrosomal factors are important in maintaining this balance, suggesting a close connection between regulation of centrosomal and Golgi-derived MTs. Finally, we will discuss potential functions of Golgi-derived MTs based on their nucleation site location within a Golgi stack. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9aba5d2d1018c1adabd3c72d108dac3Test http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00431/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f9aba5d2d1018c1adabd3c72d108dac3 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |