High level of galectin-1 expression is a negative prognostic predictor of recurrence in laryngeal squamous cell carcinomas
| العنوان: | High level of galectin-1 expression is a negative prognostic predictor of recurrence in laryngeal squamous cell carcinomas |
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| المؤلفون: | Francois Lorfevre, Christine Decaestecker, Sabine André, Diana-Raluca Cucu, Sven Saussez, Goeffrey Mortuaire, Herbert Kaltner, Agnes Wacreniez, Gérard Toubeau, Robert Kiss, Isabelle Camby, Hans-Joachim Gabius, Dominique Chevalier |
| المصدر: | International Journal of Oncology. |
| بيانات النشر: | Spandidos Publications, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Galectin 1, medicine.medical_treatment, Recurrence, otorhinolaryngologic diseases, medicine, Humans, Lymphocytes, Laryngeal Neoplasms, Aged, Retrospective Studies, Galectin, Aged, 80 and over, Oncogene, business.industry, Cancer, Immunotherapy, Middle Aged, Cell cycle, Prognosis, medicine.disease, Molecular medicine, Gene Expression Regulation, Neoplastic, stomatognathic diseases, Oncology, Galectin-1, Carcinoma, Squamous Cell, Cancer research, Immunohistochemistry, Female, business |
| الوصف: | Monitoring of gene-expression profiles is assumed to refine tumor characterization of laryngeal squamous cell carcinomas (LSCCs) with a therapeutic perspective. This is especially expected for adhesion/growth-regulatory effectors such as galectins, a class of endogenous lectins. Using computer-assisted microscopy, we investigated the prognostic value contributed by the quantitative determination of the immunohistochemical levels of expression of galectin-1, -3 and -7 in a series of 62 LSCCs including 42 low- and 20 high-stage LSCCs. As galectin-1 may have a key role leading to a tumor escape from immune surveillance, we also investigated whether or not the level of galectin-1 expression correlated with lymphocyte infiltration in LSCCs. The immunohistochemical determination of expression of galectin-1 is of prognostic value in human squamous laryngeal cancers. LSCCs that display high levels of galectin-1 have worse prognoses than laryngeal cancers with low levels of galectin-1 expression. Elevation of galectin-1 levels in laryngeal cancers can contribute to the process of tumor immune escape by killing the activated T-cells and other protumoral activities such as promoting motility or activity of oncogenic H-Ras proteins. The quantitative determination of galectin-1 in LSCCs is an independent prognostic marker when opposed to TNM staging. It has the potential to identify patients unlikely to benefit from T-cell-mediated immunotherapy, although the definitive effector function from its pro- and antitumoral activity profile has not been delineated. |
| تدمد: | 1791-2423 1019-6439 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2e73ac87e8b3062d2c36d0da194043Test https://doi.org/10.3892/ijo.30.5.1109Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bf2e73ac87e8b3062d2c36d0da194043 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912423 10196439 |
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