المؤلفون: Cristiano, Nunzia, Cabayé, Alexandre, Brabet, Isabelle, Glatthar, Ralf, Tora, Amelie, Goudet, Cyril, Bertrand, Hugues-Olivier, Goupil-Lamy, Anne, Flor, Peter, Pin, Jean-Philippe, Mccort-Tranchepain, Isabelle, Acher, Francine C.

المساهمون: Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Dassault Systèmes, Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Novartis Institutes for BioMedical Research (NIBR), University of Regensburg, Saints-Pères Paris Institute for Neurosciences (SPPIN - UMR 8003), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), ANR-13-BSV1-0006,Antares,Vers de nouveaux antalgiques ciblant les récepteurs métabotropiques du glutamate(2013)

المصدر: ISSN: 0022-2623.

مصطلحات موضوعية: [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38691510; hal-04569147; https://hal.science/hal-04569147Test; https://hal.science/hal-04569147/documentTest; https://hal.science/hal-04569147/file/Cristiano%20et%20al%20version%20finale.pdfTest; PUBMED: 38691510

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01924Test
https://hal.science/hal-04569147Test
https://hal.science/hal-04569147/documentTest
https://hal.science/hal-04569147/file/Cristiano%20et%20al%20version%20finale.pdfTest

المؤلفون: Namoto, Kenji, Baader, Clara, Orsini, Vanessa, Landshammer, Alexandro, Breuer, Eva, Dinh, Kieu Trinh, Ungricht, Rosemarie, Pikiolek, Monika, Laurent, Stephane, Lu, Bo, Aebi, Alexandra, Schönberger, Katharina, Vangrevelinghe, Eric, Evrova, Olivera, Sun, Tianliang, Annunziato, Stefano, Lachal, Julie, Redmond, Emily, Wang, Louis, Wetzel, Kristie, Capodieci, Paola, Turner, Jonathan, Schutzius, Gabi, Unterreiner, Vincent, Trunzer, Markus, Buschmann, Nicole, Behnke, Dirk, Machauer, Rainer, Scheufler, Clemens, Parker, Christian N., Ferro, Magali, Grevot, Armelle, Beyerbach, Armin, Lu, Wei-Yu, Forbes, Stuart J., Wagner, Jürgen, Bouwmeester, Tewis, Liu, Jun, Sohal, Bindi, Sahambi, Sukhdeep, Greenbaum, Linda E., Lohmann, Felix, Hoppe, Philipp, Cong, Feng, Sailer, Andreas W., Ruffner, Heinz, Glatthar, Ralf, Humar, Bostjan, Clavien, Pierre-Alain, Dill, Michael T.

المصدر: Cell Stem Cell ; volume 31, issue 4, page 554-569.e17 ; ISSN 1934-5909

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Medicine

الإتاحة: https://doi.org/10.1016/j.stem.2024.03.003Test
https://api.elsevier.com/content/article/PII:S1934590924000845?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1934590924000845?httpAccept=text/plainTest

المؤلفون: Alper, Phil, Betschart, Claudia, André, Cédric, Boulay, Thomas, Cheng, Dai, Deane, Jonathan, Faller, Michael, Feifel, Roland, Glatthar, Ralf, Han, Dong, Hemmig, Rene, Jiang, Tao, Knoepfel, Thomas, Maginnis, Jillian, Mutnick, Daniel, Pei, Wei, Ruzzante, Giulia, Syka, Peter, Zhang, Guobao, Zhang, Yi

المصدر: ACS Medicinal Chemistry Letters; 8/10/2023, Vol. 14 Issue 8, p1054-1062, 9p

المؤلفون: Michellys, Pierre-Yves, Pei, Wei, Zhang, Yi, Jiang, Tao, Han, Dong, Zhang, Guobao, Chang, Dai, Alper, Phillip, Mutnick, Daniel, Deane, Jonathan, Syka, Peter, Maginnis, Jillian, Junt, Tobias, Knoepfel, Thomas, Betschart, Claudia, Glatthar, Ralf, Feifel, Roland, Faller, Michael, Hemmig, Rene, Zink, Florence

العلاقة: Michellys, Pierre-Yves, Pei, Wei, Zhang, Yi, Jiang, Tao, Han, Dong, Zhang, Guobao, Chang, Dai, Alper, Phillip, Mutnick, Daniel, Deane, Jonathan, Syka, Peter, Maginnis, Jillian, Junt, Tobias, Knoepfel, Thomas, Betschart, Claudia, Glatthar, Ralf, Feifel, Roland, Faller, Michael, Hemmig, Rene and Zink, Florence (2023) Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases. ACS medicinal chemistry letters, 14 (8). pp. 1054-1062. ISSN 1948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00136Test
https://oak.novartis.com/48414Test/
https://urldefense.com/v3/__https://pubs.acs.org/articlesonrequest/AOR-XMSQJCAESAJE7ANDBGJR__;!!N3hqHg43uw!uFA3uM4olcCL8tpKCJYXYyL3M18AlqJHvL11w9Hn1C8hAOd_Qr-Gh2R1bCZu3OuuUBvMawz8PHcn3D4u2P0BKWejMgTest$

المؤلفون: Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, Rene, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sebastien, Junt, Tobias, Collignon Zipfel, Geraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland, Knoepfel, Thomas

العلاقة: Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, Rene, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sebastien, Junt, Tobias, Collignon Zipfel, Geraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland and Knoepfel, Thomas (2022) Structure-based optimization of a fragment like TLR8 binding screening hit to an in vivo efficacious TLR7/8 antagonist. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.1c00696Test
https://oak.novartis.com/46530Test/

المؤلفون: Namoto, Kenji, Baader, Clara, Orsini, Vanessa, Landshammer, Alexandro, Breuer, Eva, Dinh, Kieu Trinh, Ungricht, Rosemarie, Pikiolek, Monika, Laurent, Stephane, Lu, Bo, Aebi, Alexandra, Schönberger, Katharina, Vangrevelinghe, Eric, Evrova, Olivera, Sun, Tianliang, Annunziato, Stefano, Lachal, Julie, Redmond, Emily, Wang, Louis, Wetzel, Kristie, Capodieci, Paola, Turner, Jonathan, Schutzius, Gabi, Unterreiner, Vincent, Trunzer, Markus, Buschmann, Nicole, Behnke, Dirk, Machauer, Rainer, Scheufler, Clemens, Parker, Christian N., Ferro, Magali, Grevot, Armelle, Beyerbach, Armin, Lu, Wei-Yu, Forbes, Stuart J., Wagner, Jürgen, Bouwmeester, Tewis, Liu, Jun, Sohal, Bindi, Sahambi, Sukhdeep, Greenbaum, Linda E., Lohmann, Felix, Hoppe, Philipp, Cong, Feng, Sailer, Andreas W., Ruffner, Heinz, Glatthar, Ralf, Humar, Bostjan, Clavien, Pierre-Alain, Dill, Michael T.

مصطلحات موضوعية: Crystal Structure, Experimental 3D Coordinates, Crystal System, Space Group, Cell Parameters, Crystallography, R-N-{4-[piperidin-3-yloxy]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-amine methanol solvate

وصف الملف: CIF

العلاقة: https://dx.doi.org/10.1016/j.stem.2024.03.003Test

الإتاحة: https://doi.org/10.5517/ccdc.csd.cc2jl57k10.1016/j.stem.2024.03.003Test

المؤلفون: Gutmann, Sascha, Hinniger, Alexandra, Fendrich, Gabriele, Drückes, Peter, Antz, Sylvie, Mattes, Henri, Möbitz, Henrik, Ofner, Silvio, Schmiedeberg, Niko, Stojanovic, Aleksandar, Rieffel, Sebastien, Strauss, André, Troxler, Thomas, Glatthar, Ralf, Sparrer, Helmut

المصدر: Journal of Biological Chemistry ; volume 290, issue 24, page 15210-15218 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.m115.648097Test
https://api.elsevier.com/content/article/PII:S0021925820443868?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820443868?httpAccept=text/plainTest

المؤلفون: Gee, Christine E., Peterlik, Daniel, Neuhäuser, Christoph, Bouhelal, Rochdi, Kaupmann, Klemens, Laue, Grit, Uschold-Schmidt, Nicole, Feuerbach, Dominik, Zimmermann, Kaspar, Ofner, Silvio, Cryan, John F., van der Putten, Herman, Fendt, Markus, Vranesic, Ivo, Glatthar, Ralf, Flor, Peter J.

المصدر: Journal of Biological Chemistry ; volume 289, issue 16, page 10975-10987 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.m113.542654Test
https://api.elsevier.com/content/article/PII:S0021925820483176?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820483176?httpAccept=text/plainTest

المؤلفون: Knoepfel, Thomas, Nimsgern, Pierre, Jacquier, Sebastien, Bourrel, Marjorie, Vangrevelinghe, Eric, Glatthar, Ralf, Behnke, Dirk, Alper, Phillip, Michellys, Pierre, Deane, Jonathan, Junt, Tobias, Collignon Zipfel, Geraldine, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Loetscher, Pius, Faller, Michael, Blank, Jutta, Feifel, Roland, Betschart, Claudia

العلاقة: Knoepfel, Thomas, Nimsgern, Pierre, Jacquier, Sebastien, Bourrel, Marjorie, Vangrevelinghe, Eric, Glatthar, Ralf, Behnke, Dirk, Alper, Phillip, Michellys, Pierre, Deane, Jonathan, Junt, Tobias, Collignon Zipfel, Geraldine, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Loetscher, Pius, Faller, Michael, Blank, Jutta, Feifel, Roland and Betschart, Claudia (2020) Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists using a Biochemical TLR8 Antagonist Competition Assay. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.0c00130Test
https://oak.novartis.com/41810Test/