دورية أكاديمية
Personality change in a trial of psilocybin therapy vs escitalopram treatment for depression
| العنوان: | Personality change in a trial of psilocybin therapy vs escitalopram treatment for depression |
|---|---|
| المؤلفون: | Weiss, B, Ginige, I, Shannon, L, Giribaldi, B, Murphy-Beiner, A, Murphy, R, Baker-Jones, M, Martell, J, Nutt, DJ, Carhart-Harris, RL, Erritzoe, D |
| بيانات النشر: | Cambridge University Press |
| سنة النشر: | 2023 |
| المجموعة: | Imperial College London: Spiral |
| الوصف: | Background: Psilocybin Therapy (PT) is being increasingly studied as a psychiatric intervention. Personality relates to mental health and can be used to probe the nature of PT's therapeutic action. Methods: In a phase 2, double-blind, randomized, active comparator controlled trial involving patients with moderate-to-severe major depressive disorder, we compared psilocybin with escitalopram, over a core 6-week trial period. Five-Factor model personality domains, Big Five Aspect Scale Openness aspects, Absorption, and Impulsivity were measured at Baseline, Week 6, and Month 6 follow-up. Results: PT was associated with decreases in neuroticism (B = −0.63), introversion (B = −0.38), disagreeableness (B = −0.47), impulsivity (B = −0.40), and increases in absorption (B = 0.32), conscientiousness (B = 0.30), and openness (B = 0.23) at week 6, with neuroticism (B = −0.47) and disagreeableness (B = −0.41) remaining decreased at month 6. Escitalopram Treatment (ET) was associated with decreases in neuroticism (B = −0.38), disagreeableness (B = −0.26), impulsivity (B = −0.35), and increases in openness (B = 0.28) at week 6, with neuroticism (B = −0.46) remaining decreased at month 6. No significant between-condition differences were observed. Conclusions: Personality changes across both conditions were in a direction consistent with improved mental health. With the possible exception of trait absorption, there were no compelling between-condition differences warranting conclusions regarding a selective action of PT (v. ET) on personality; however, post-ET changes in personality were significantly moderated by pre-trial positive expectancy for escitalopram, whereas expectancy did not moderate response to PT. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0033-2917 |
| العلاقة: | Psychological Medicine; http://hdl.handle.net/10044/1/104385Test |
| DOI: | 10.1017/S0033291723001514 |
| الإتاحة: | https://doi.org/10.1017/S0033291723001514Test http://hdl.handle.net/10044/1/104385Test |
| حقوق: | © The Author(s), 2023. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.B36F1F42 |
| قاعدة البيانات: | BASE |
| تدمد: | 00332917 |
|---|---|
| DOI: | 10.1017/S0033291723001514 |