Cholinergic dysfunction in subcortical ischaemic vascular dementia: a transcranial magnetic stimulation study
| العنوان: | Cholinergic dysfunction in subcortical ischaemic vascular dementia: a transcranial magnetic stimulation study |
|---|---|
| المؤلفون: | Stefan Golaszewski, Raffaele Nardone, Jürgen Bergmann, Frediano Tezzon, Gihither Ladurner |
| المصدر: | Journal of Neural Transmission. 115:737-743 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Neurology, medicine.medical_treatment, Neuropsychological Tests, Statistics, Nonparametric, Neurochemical, Reaction Time, medicine, Humans, Dementia, Vascular dementia, Biological Psychiatry, Aged, Dementia, Vascular, Motor Cortex, Human brain, Middle Aged, Evoked Potentials, Motor, medicine.disease, Transcranial Magnetic Stimulation, Electric Stimulation, Transcranial magnetic stimulation, Psychiatry and Mental health, medicine.anatomical_structure, Cholinergic, Female, Neurology (clinical), Psychology, Neuroscience, Motor cortex |
| الوصف: | Little is known about the neurochemical pathology of vascular dementia (VD); it was suggested that cholinergic mechanisms play a role in the pathogenesis of VD, as well as been established for Alzheimer's disease (AD). A recently devised test of motor cortex excitability, the short latency afferent inhibition (SAI), has been proven to depend upon the activity of cholinergic circuits in the human brain. To evaluate, in vivo, the functional role of the cholinergic system in the cognitive dysfunction associated with VD, we used this test in 20 patients with subcortical ischemic VD (SIVD) and in 25 control subjects. Mean SAI was significantly reduced in the SIVD patients; however, individual data varied widely, with SAI responses ranging from normal to markedly reduced values. These findings provide physiological evidence for an important role for cholinergic mechanisms in the pathogenesis of VD. The evaluation of SAI, similar to that described in AD patients, could help in identifying those patients who are more likely to respond to treatment with cholinergic drugs. |
| تدمد: | 1435-1463 0300-9564 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cb081e5bc0ed9a8c9eafcf984524faTest https://doi.org/10.1007/s00702-007-0003-6Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....28cb081e5bc0ed9a8c9eafcf984524fa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14351463 03009564 |
|---|