دورية أكاديمية
Constipation distinguishes different clinical-biochemical patterns in de novo Parkinson's disease
| العنوان: | Constipation distinguishes different clinical-biochemical patterns in de novo Parkinson's disease |
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| المؤلفون: | Grillo, Piergiorgio, Sancesario, Giulia Maria, Mascioli, Davide, Geusa, Lorenza, Zenuni, Henri, Giannella, Emilia, Della Morte, David, Mercuri, Nicola Biagio, Schirinzi, Tommaso |
| المساهمون: | Grillo, P, Sancesario, Gm, Mascioli, D, Geusa, L, Zenuni, H, Giannella, E, Della Morte, D, Mercuri, Nb, Schirinzi, T |
| بيانات النشر: | ELSEVIER SCI LTD |
| سنة النشر: | 2022 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | Alpha-synuclein, Blood-brain barrier, Cerebrospinal fluid, Constipation, Parkinson disease, Settore MED/26 - NEUROLOGIA |
| الوصف: | Introduction: Prodromal constipation (PC) at Parkinson's disease (PD) onset may mark a distinct neurodegen-erative trajectory; accordingly, presenting phenotype, biochemical signature, and progression of PD patients with PC (PD + PC) might differ from those without (PDwoPC). We compared the clinical-biochemical profile of de novo PD patients with and without PC, and the respective mid-term progression, to establish the grouping effect of PC. Methods: Motor and non-motor scores were collected at diagnosis in n = 57 PD + PC patients and n = 73 PDwoPC. Paired CSF biomarkers (alpha-synuclein, amyloid and tau peptides, lactate, CSF/serum albumin ratio or AR) were assessed into a smaller sample and n = 46 controls. Clinical progression was estimated as Hoehn and Yahr stage (HY) and levodopa equivalent daily dose (LEDD) change 2.06 +/- 1.35 years after diagnosis. Results: At onset, PD + PC patients had higher HY and MDS-UPDRS-part III scores, and higher CSF AR. PDwoPC had higher Non-Motor Symptoms Scale domain-2 score, and lower CSF alpha-synuclein level. At follow-up, PD + PC had greater LEDD. Conclusions: PC identifies a group of de novo patients with more severe motor impairment, possible blood brain barrier disruption, and greater dopaminergic requirement at mid-term; conversely, de novo PDwoPC patients had prominent fatigue, and pronounced central synucleinopathy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35963045; info:eu-repo/semantics/altIdentifier/wos/WOS:000862945100011; volume:102; firstpage:64; lastpage:67; numberofpages:4; journal:PARKINSONISM & RELATED DISORDERS; https://hdl.handle.net/2108/311815Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85135716497 |
| DOI: | 10.1016/j.parkreldis.2022.08.001 |
| الإتاحة: | https://doi.org/10.1016/j.parkreldis.2022.08.001Test https://hdl.handle.net/2108/311815Test |
| رقم الانضمام: | edsbas.9D15E9B9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.parkreldis.2022.08.001 |
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