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1
المؤلفون: Nancy Torres, Eileen Frommer, Bloom Jonathan David, Karen Collins, Dunnick Alejandro Lee, George Diamantidis, Yongbo Hu, Minu Dutia, Christoph W. Zapf, Zhang Chunchun, Darrin William Hopper, Dan Maarten Berger, Donald Wojciechowicz, Dennis Powell, Martin Di Grandi, Jeremy I. Levin
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6957-6961
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Pyridines, Isostere, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Enzyme Inhibitors, Cytotoxicity, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Indazole, biology, Bicyclic molecule, Cell growth, Organic Chemistry, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6346230a46b93ee107f73ab7d8869701Test
https://doi.org/10.1016/j.bmcl.2009.10.058Test -
2
المؤلفون: Karen L. Marquis, Suzan Aschmies, Hua Zhou, Robert Martone, Kevin Atchison, June Sonnenberg-Reines, Anthony Kreft, Menelas N. Pangalos, Thomas A. Comery, J. Steven Jacobsen, George Diamantidis, Xiaohai Gong
المصدر: The Journal of Neuroscience. 25:8898-8902
مصطلحات موضوعية: Genetically modified mouse, Aging, medicine.medical_specialty, Amyloid, Phosphodiesterase Inhibitors, Transgene, Mice, Transgenic, Amyloid beta-Protein Precursor, Mice, Cognition, Alzheimer Disease, Internal medicine, Conditioning, Psychological, Endopeptidases, medicine, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Dementia, Enzyme Inhibitors, Pathological, Triglycerides, gamma-Aminobutyric Acid, Rolipram, Amyloid beta-Peptides, biology, General Neuroscience, Fear, medicine.disease, Cyclic Nucleotide Phosphodiesterases, Type 4, Disease Models, Animal, Endocrinology, 3',5'-Cyclic-AMP Phosphodiesterases, Mutation, biology.protein, Amyloid Precursor Protein Secretases, Brief Communications, Cognition Disorders, Psychology, Neuroscience, Amyloid precursor protein secretase, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b492d9ca4d6361b6a9a861cd42e865Test
https://doi.org/10.1523/jneurosci.2693-05.2005Test -
3
المؤلفون: Stacy W. Remiszewski, Lidia C. Sambucetti, Kenneth W. Bair, John Bontempo, David Cesarz, Nagarajan Chandramouli, Ru Chen, Min Cheung, Susan Cornell-Kennon, Karl Dean, George Diamantidis, Dennis France, Michael A. Green, Kobporn Lulu Howell, Rina Kashi, Paul Kwon, Peter Lassota, Mary S. Martin, Yin Mou, Lawrence B. Perez, Sushil Sharma, Troy Smith, Eric Sorensen, Francis Taplin, Nancy Trogani, Richard Versace, Heather Walker, Susan Weltchek-Engler, Alexander Wood, Arthur Wu, Peter Atadja
المصدر: Journal of Medicinal Chemistry. 46:4609-4624
مصطلحات موضوعية: Hydroxamic acid, biology, Biological activity, Pharmacology, Enzyme assay, chemistry.chemical_compound, chemistry, Biochemistry, In vivo, Enzyme inhibitor, Drug Discovery, biology.protein, Molecular Medicine, Histone deacetylase, Growth inhibition, neoplasms, IC50
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6e0206bc14fdb324b1acbdd17eeea9ccTest
https://doi.org/10.1021/jm030235wTest -
4
المؤلفون: Boyd L. Harrison, Dennis Kubrak, Kimberly Sogi, George Diamantidis, Anthony F. Kreft, Zheng Wang, Zhang Minsheng, Scott Christian Mayer, Lynn Resnick, Alex Porte
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:2401-2403
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Chemistry, Pharmaceutical, Organic Chemistry, Clinical Biochemistry, Chemistry, Organic, Molecular Conformation, Enantioselective synthesis, Pharmaceutical Science, General Medicine, Biochemistry, Chemical synthesis, Amino acid, Models, Chemical, chemistry, Feature (computer vision), Drug Design, Drug Discovery, Side chain, Molecular Medicine, Amino Acids, Aliphatic compound, Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10629f0ae1e5e7fe396806c331fa68bTest
https://doi.org/10.1016/j.bmcl.2007.02.041Test -
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المؤلفون: Hong Fan, T. R. Wagler, K. Natalie, Ramachandran S. Ranganathan, Thangavel Arunachalam, N. Soundararajan, George Diamantidis, C.-K. Chen, K. M. R. Pillai, Edmund R. Marinelli, R. Neubeck, J. Emswiler
المصدر: ChemInform. 28
مصطلحات موضوعية: Chemistry, X-ray, Organic chemistry, General Medicine, Contrast (music), Conjugated system, Pyrrole derivatives
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e3ba5dcd65bf4fbbd4bf53fdeada30d3Test
https://doi.org/10.1002/chin.199701174Test -
6
المؤلفون: Joshua D Berkowitz, Boyd L. Harrison, Robert Martone, Hua Zhou, Micheal Chlenov, Yun Hu, Peimin Lu, Koi Michele Morris, June Sonnenberg-Reines, S. Aschmies, Joan E. Sabalski, Kerri Lipinski, George Diamantidis, Kevin Atchison, Thomas J. Caggiano, Shaiu-Ching Sun, Zheng Xu, Jun Pu, Anthony F. Kreft, Dave R. Riddell, Yiqun Wang, Lynn Resnick, Mei Jin, Donna M. Huryn, Erik Wagner, J. Steven Jacobsen
المصدر: Bioorganicmedicinal chemistry. 17(13)
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, CHO Cells, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Cricetulus, Alzheimer Disease, Heterocyclic Compounds, Cricetinae, Drug Discovery, medicine, Amyloid precursor protein, Structure–activity relationship, Animals, Humans, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Amyloid beta-Peptides, biology, Molecular Structure, Receptors, Notch, Organic Chemistry, medicine.disease, Sulfonamide, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Alzheimer's disease, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb35335c5e137415c463df8839ade10Test
https://pubmed.ncbi.nlm.nih.gov/19443228Test -
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المؤلفون: Ron Magolda, Joseph R. Stock, David Riddell, Scott C. Mayer, John Ellingboe, Ting Wang, Melissa Lin, Hua Zhou, Yun Hu, Galante Rocco, Dennis M. Kubrak, Mei Jin, Madelene Miyoko Antane, Aram Oganesian, Anthony Kreft, Margaret M. Zaleska, Derek C. Cole, Michael Chlenov, Minsheng Zhang, Menelas N. Pangalos, Alex M. Porte, J. Steven Jacobsen, Lynn Resnick, Joseph Zeldis, Kristi Fan, Donna M. Huryn, Uday Jain, Shaiu-Ching Sun, Cathleen Gonzales, Boyd L. Harrison, William E. Moore, Peimin Lu, Magid Abou-Gharbia, Thomas A. Comery, Molly Hoke, Suzan Aschmies, George Diamantidis, Kevin R. Woller, Peter H. Reinhart, Robert Martone, June Sonnenberg-Reines, Kevin Atchison, Erik Wagner, Zheng Xu, Douglas M. Ho, Kenneth Alfred Martin Kremer
المصدر: Journal of medicinal chemistry. 51(23)
مصطلحات موضوعية: Models, Molecular, Notch signaling pathway, Molecular Conformation, Mice, Transgenic, Thiophenes, Pharmacology, Crystallography, X-Ray, Mice, Structure-Activity Relationship, In vivo, Alzheimer Disease, Drug Discovery, Amyloid precursor protein, medicine, Structure–activity relationship, Potency, Animals, Enzyme Inhibitors, Receptor, Notch1, Notch 1, Sulfonamides, Amyloid beta-Peptides, biology, Dose-Response Relationship, Drug, Chemistry, Stereoisomerism, medicine.disease, Disease Models, Animal, Biochemistry, biology.protein, Molecular Medicine, Alzheimer's disease, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c063931baa66ff9027ac9d0def280432Test
https://pubmed.ncbi.nlm.nih.gov/19012391Test -
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المؤلفون: Peimin Lu, David S. Casebier, Dennis Kubrak, S. Aschmies, David Riddell, William Jay Moore, Zheng Wang, Mei Jin, Hua Zhou, Thomas A. Comery, John W. Ellingboe, Shaiu-Ching Sun, Erik Wagner, Aram Oganesian, Joseph Raymond Stock, Boyd L. Harrison, Zheng Xu, Robert Martone, George Diamantidis, Madelene Antane, Kevin Atchison, Kevin R. Woller, Yun Hu, June Sonnenberg-Reines, Charles William Mann, J. Steven Jacobsen, Anthony F. Kreft, Derek C. Cole
المصدر: Bioorganicmedicinal chemistry letters. 19(3)
مصطلحات موضوعية: Clinical Biochemistry, Notch signaling pathway, Pharmaceutical Science, Cleavage (embryo), Biochemistry, Propanolamines, Amyloid beta-Protein Precursor, In vivo, Alzheimer Disease, Drug Discovery, Amyloid precursor protein, Animals, Humans, Isoleucine, Receptor, Notch1, Molecular Biology, Notch 1, Sulfonyl, chemistry.chemical_classification, Sulfonamides, biology, Chemistry, Organic Chemistry, Molecular biology, In vitro, Models, Chemical, Alcohols, Drug Design, biology.protein, Molecular Medicine, Signal transduction, Amyloid Precursor Protein Secretases
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f145553716fc797084c8e75ab564dd0Test
https://pubmed.ncbi.nlm.nih.gov/19097890Test -
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المؤلفون: Magid Abou-Gharbia, Anthony Kreft, Peter H. Reinhart, J. Steven Jacobsen, Kevin Atchison, Robert Martone, Scott C. Mayer, Lynn Resnick, Ronald L. Magolda, Menelas N. Pangalos, Dennis M. Kubrak, Boyd L. Harrison, Kerri Lipinski, Ann Aulabaugh, Warren D. Hirst, Hua Zhou, Xinyi Huang, Michael K. May, Alex M. Porte, George Diamantidis
المصدر: Alzheimer's & Dementia. 4
مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Chemistry, Health Policy, Benchmark (computing), Neurology (clinical), Computational biology, Geriatrics and Gerontology, Gamma secretase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4e136400868e4fe04c7474ae796b5ac4Test
https://doi.org/10.1016/j.jalz.2008.05.1414Test -
10
المؤلفون: Hua Zhou, John W. Ellingboe, Derek Cecil Cole, Donna M. Huryn, Suzan Aschmies, Mei Jin, Charles William Mann, William E. Moore, Robert Martone, David S. Casebier, George Diamantidis, Zheng Xu, Alex Porte, Kevin R. Woller, Kevin Atchison, Anthony F. Kreft, Erik Wagner, Yun Hu, June Sonnenberg-Reines, Joseph T. Lundquist, J. Steven Jacobsen, Dennis Kubrak, Dave R. Riddell, Peimin Lu, Diane B. Hauze, Joseph Raymond Stock, Shaiu-Ching Sun, Boyd L. Harrison, Aram Oganesian
المصدر: Bioorganicmedicinal chemistry letters. 18(14)
مصطلحات موضوعية: Amyloid, Chemistry, Pharmaceutical, Clinical Biochemistry, Cell, Notch signaling pathway, Drug Evaluation, Preclinical, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, Alzheimer Disease, Drug Discovery, medicine, Amyloid precursor protein, Structure–activity relationship, Humans, Protease inhibitor (pharmacology), Enzyme Inhibitors, Molecular Biology, Gamma secretase, integumentary system, biology, Receptors, Notch, Chemistry, Organic Chemistry, Carbon, medicine.anatomical_structure, Models, Chemical, Enzyme inhibitor, Drug Design, biology.protein, Cancer research, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2478e69d5a0c4998fbffb6b302c18ddbTest
https://pubmed.ncbi.nlm.nih.gov/18556202Test