Gene‐lifestyle interaction on risk of type 2 diabetes: A systematic review
| العنوان: | Gene‐lifestyle interaction on risk of type 2 diabetes: A systematic review |
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| المؤلفون: | Ju-Sheng Zheng, Lukas Schwingshackl, Karina Meidtner, Stefan Dietrich, Simone Jacobs, Matthias B. Schulze |
| المصدر: | Obesity Reviews |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Endocrinology, Diabetes and Metabolism, Population, MEDLINE, physical activity, 030209 endocrinology & metabolism, Type 2 diabetes, Bioinformatics, Polymorphism, Single Nucleotide, ABCC8, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Ethnicity, medicine, Humans, Genetic Predisposition to Disease, Prospective Studies, 030212 general & internal medicine, education, Prospective cohort study, weight loss intervention, education.field_of_study, biology, business.industry, Incidence (epidemiology), Public Health, Environmental and Occupational Health, Genetic Variation, medicine.disease, HNF1B, incident type 2 diabetes, Diabetes Mellitus, Type 2, gene‐lifestyle interaction, Diet, Western, biology.protein, Gene-Environment Interaction, Genetics/Obesity Comorbidity, Diet, Healthy, diet, business, Transcription Factor 7-Like 2 Protein, TCF7L2, Genome-Wide Association Study |
| الوصف: | Summary The pathophysiological influence of gene‐lifestyle interactions on the risk to develop type 2 diabetes (T2D) is currently under intensive research. This systematic review summarizes the evidence for gene‐lifestyle interactions regarding T2D incidence. MEDLINE, EMBASE, and Web of Science were systematically searched until 31 January 2019 to identify publication with (a) prospective study design; (b) T2D incidence; (c) gene‐diet, gene‐physical activity, and gene‐weight loss intervention interaction; and (d) population who are healthy or prediabetic. Of 66 eligible publications, 28 reported significant interactions. A variety of different genetic variants and dietary factors were studied. Variants at TCF7L2 were most frequently investigated and showed interactions with fiber and whole grain on T2D incidence. Further gene‐diet interactions were reported for, eg, a western dietary pattern with a T2D‐GRS, fat and carbohydrate with IRS1 rs2943641, and heme iron with variants of HFE. Physical activity showed interaction with HNF1B, IRS1, PPARγ, ADRA2B, SLC2A2, and ABCC8 variants and weight loss interventions with ENPP1, PPARγ, ADIPOR2, ADRA2B, TNFα, and LIPC variants. However, most findings represent single study findings obtained in European ethnicities. Although some interactions have been reported, their conclusiveness is still low, as most findings were not yet replicated across multiple study populations. |
| تدمد: | 1467-789X 1467-7881 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786e4fe02d1ec2736543aba482181f2bTest https://doi.org/10.1111/obr.12921Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....786e4fe02d1ec2736543aba482181f2b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1467789X 14677881 |
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