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1دورية أكاديمية
المؤلفون: Baker, Brenda, Xia, Shuting, Partridge, Wesley, Kwoh, T, Tsimikas, Sotirios, Bhanot, Sanjay, Geary, Richard
المصدر: Nucleic Acid Therapeutics. 33(1)
مصطلحات موضوعية: integrated safety analysis, ligand-conjugated antisense technology, phase 2, randomized placebo-controlled trials, triantennary N-acetylgalactosamine, Humans, Oligonucleotides, Antisense, Ligands, Hepatocytes, Oligonucleotides, RNA
وصف الملف: application/pdf
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2دورية أكاديمية
المؤلفون: Tardif, Jean-Claude, Investigators, for the Olezarsen Study, Karwatowska-Prokopczuk, Ewa, St Amour, Eric, Ballantyne, Christie M, Shapiro, Michael D, Moriarty, Patrick M, Baum, Seth J, Hurh, Eunju, Bartlett, Victoria J, Kingsbury, Joyce, Figueroa, Amparo L, Alexander, Veronica J, Tami, Joseph, Witztum, Joseph L, Geary, Richard S, St L O’Dea, Louis, Tsimikas, Sotirios, Gaudet, Daniel
المصدر: European Heart Journal. 43(14)
مصطلحات موضوعية: Clinical Trials and Supportive Activities, Prevention, Cardiovascular, Heart Disease, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Good Health and Well Being, Apolipoprotein C-III, Cardiovascular Diseases, Cholesterol, Heart Disease Risk Factors, Humans, Hypertriglyceridemia, Lipoproteins, Risk Factors, Triglycerides, Atherosclerosis, Cardiovascular disease, Cardiovascular risk factors, Hypertriglyceridaemia, apoC-III, Antisense, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/52k3p81sTest
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3دورية أكاديمية
المؤلفون: Coelho, Teresa, Ando, Yukio, Benson, Merrill D, Berk, John L, Waddington-Cruz, Márcia, Dyck, Peter J, Gillmore, Julian D, Khella, Sami L, Litchy, William J, Obici, Laura, Monteiro, Cecilia, Tai, Li-Jung, Viney, Nicholas J, Buchele, Gustavo, Brambatti, Michela, Jung, Shiangtung W, St. L. O’Dea, Louis, Tsimikas, Sotirios, Schneider, Eugene, Geary, Richard S, Monia, Brett P, Gertz, Morie
المصدر: Neurology and Therapy. 10(1)
مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Rare Diseases, Clinical Trials and Supportive Activities, Neurosciences, Orphan Drug, Clinical Research, Peripheral Neuropathy, Neurodegenerative, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, AKCEA-TTR-L-rx, Antisense oligonucleotide, Clinical trial design, Hereditary transthyretin-mediated amyloid polyneuropathy, Phase 3 clinical trial, AKCEA-TTR-Lrx, Clinical sciences
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/2q73t715Test
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4دورية أكاديمية
المؤلفون: Morgan, Erin S, Tami, Yvonne, Hu, Kuolung, Brambatti, Michela, Mullick, Adam E, Geary, Richard S, Bakris, George L, Tsimikas, Sotirios
المصدر: JACC Basic to Translational Science. 6(6)
مصطلحات موضوعية: Hypertension, Clinical Trials and Supportive Activities, Clinical Research, Cardiovascular, Evaluation of treatments and therapeutic interventions, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals, angiotensinogen, antisense, hepatocyte, hypertension, oligonucleotide, RAAS, ACEi/ARB, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, AGT, angiotensinogen, ASO, antisense oligonucleotide, CI, confidence interval, DBP, diastolic blood pressure, EDTA, ethylenediaminetetraacetic acid, GalNAc3, triantennary N-acetyl galactosamine, K+, potassium, PS, phosphorothioate, RAAS, renin-angiotensin-aldosterone system, SBP, systolic blood pressure, Cardiorespiratory Medicine and Haematology, Clinical Sciences
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/2988h4bdTest
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5دورية أكاديمية
المؤلفون: Viney, Nicholas J, Guo, Shuling, Tai, Li‐Jung, Baker, Brenda F, Aghajan, Mariam, Jung, Shiangtung W, Yu, Rosie Z, Booten, Sheri, Murray, Heather, Machemer, Todd, Burel, Sebastien, Murray, Sue, Buchele, Gustavo, Tsimikas, Sotirios, Schneider, Eugene, Geary, Richard S, Benson, Merrill D, Monia, Brett P
المصدر: ESC Heart Failure. 8(1)
مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Cancer, Clinical Trials and Supportive Activities, Clinical Research, Liver Disease, Rare Diseases, Biotechnology, Orphan Drug, Digestive Diseases, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Amyloid Neuropathies, Familial, Animals, Ligands, Mice, Oligonucleotides, Antisense, Prealbumin, Transthyretin, Amyloidosis, Cardiomyopathy, Polyneuropathy, Antisense, Ligand-conjugated, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/41n576q7Test
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6دورية أكاديمية
المؤلفون: Gaudet, Daniel, Karwatowska-Prokopczuk, Ewa, Baum, Seth J, Hurh, Eunju, Kingsbury, Joyce, Bartlett, Victoria J, Figueroa, Amparo L, Piscitelli, Philip, Singleton, Walter, Witztum, Joseph L, Geary, Richard S, Tsimikas, Sotirios, St. L O'Dea, Louis, Investigators, the Vupanorsen Study
المصدر: European Heart Journal. 41(40)
مصطلحات موضوعية: Clinical Trials and Supportive Activities, Atherosclerosis, Nutrition, Diabetes, Cardiovascular, Digestive Diseases, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Metabolic and endocrine, Angiopoietin-Like Protein 3, Angiopoietin-like Proteins, Diabetes Mellitus, Type 2, Double-Blind Method, Galactosamine, Humans, Hypertriglyceridemia, Lipoproteins, Pharmaceutical Preparations, RNA, Messenger, Triglycerides, Angiopoietin-like protein 3, Antisense, Vupanorsen, Hypertriglyceridaemia, Cardiovascular disease, Vupanorsen Study Investigators, Angiopoietin-like protein 3, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/43x8j0kxTest
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7دورية أكاديمية
المؤلفون: Loomba, Rohit, Morgan, Erin, Watts, Lynnetta, Xia, Shuting, Hannan, Lisa A, Geary, Richard S, Baker, Brenda F, Bhanot, Sanjay
المصدر: The Lancet Gastroenterology & Hepatology. 5(9)
مصطلحات موضوعية: Prevention, Chronic Liver Disease and Cirrhosis, Clinical Research, Digestive Diseases, Patient Safety, Clinical Trials and Supportive Activities, Hepatitis, Liver Disease, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Oral and gastrointestinal, Good Health and Well Being, Aged, Body Mass Index, Canada, Case-Control Studies, Diabetes Mellitus, Type 2, Diacylglycerol O-Acyltransferase, Double-Blind Method, Drug Tolerance, Female, Humans, Hungary, Injections, Subcutaneous, Intra-Abdominal Fat, Magnetic Resonance Imaging, Male, Middle Aged, Non-alcoholic Fatty Liver Disease, Oligonucleotides, Antisense, Placebos, Poland, Safety, Treatment Outcome
الوصول الحر: https://escholarship.org/uc/item/3q1381stTest
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8دورية أكاديمية
المؤلفون: Watts, Lynnetta M, Karwatowska-Prokopczuk, Ewa, Hurh, Eunju, Alexander, Veronica J, Balogh, Kristin, O'Dea, Louis, Geary, Richard S, Tsimikas, Sotirios
المصدر: Nucleic Acid Therapeutics. 30(4)
مصطلحات موضوعية: Biological Sciences, Clinical Trials and Supportive Activities, Clinical Research, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Apolipoprotein C-III, Dose-Response Relationship, Drug, Double-Blind Method, Drug-Related Side Effects and Adverse Reactions, Electrocardiography, Female, Healthy Volunteers, Humans, Hypertriglyceridemia, Male, Moxifloxacin, Oligonucleotides, Oligonucleotides, Antisense, Placebo Effect, RNA, Messenger, Triglycerides, QTc interval, antisense oligonucleotide, subcutaneous (SC) therapeutic dose, supratherapeutic dose, volanesorsen, Technology, Biochemistry & Molecular Biology, Pharmacology & Pharmacy, Biological sciences
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/5dd0f5mjTest
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9دورية أكاديمية
المؤلفون: Alexander, Veronica J, Xia, Shuting, Hurh, Eunju, Hughes, Steven G, O’Dea, Louis, Geary, Richard S, Witztum, Joseph L, Tsimikas, Sotirios
المصدر: European Heart Journal. 40(33)
مصطلحات موضوعية: Atherosclerosis, Cardiovascular, Heart Disease, Clinical Trials and Supportive Activities, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Adolescent, Adult, Aged, Apolipoprotein C-III, Apolipoproteins B, Cholesterol, Double-Blind Method, Drug Administration Schedule, Female, Humans, Hypertriglyceridemia, Male, Middle Aged, Oligonucleotides, RNA, Messenger, Treatment Outcome, Young Adult, Hypertriglyceridaemia, Antisense, Cardiovascular disease, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/9vj5m52wTest
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10دورية أكاديمية
المؤلفون: Crooke, Stanley T, Baker, Brenda F, Xia, Shuting, Yu, Rosie Z, Viney, Nicholas J, Wang, Yanfeng, Tsimikas, Sotirios, Geary, Richard S
المصدر: Nucleic Acid Therapeutics. 29(1)
مصطلحات موضوعية: Biological Sciences, 5.2 Cellular and gene therapies, Development of treatments and therapeutic interventions, Acetylgalactosamine, Asialoglycoprotein Receptor, Biomarkers, Pharmacological, Dose-Response Relationship, Drug, Female, Healthy Volunteers, Hepatocytes, Humans, Male, Middle Aged, Oligonucleotides, Antisense, Phosphorothioate Oligonucleotides, RNA, Structure-Activity Relationship, antisense, oligonucleotide, assessment, clinical trials, triantennary N-acetylgalactosamine, triantennary -acetylgalactosamine, Technology, Biochemistry & Molecular Biology, Pharmacology & Pharmacy, Biological sciences
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/4z01p1htTest