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1دورية أكاديمية
المؤلفون: Liqi He, Meng Yao Zhang, Matthew Cox, Qian Zhang, Andrew F. Donnell, Yong Zhang, Christine Tarby, Patrice Gill, Murugaiah A. M. Subbaiah, Thangeswaran Ramar, Maheswara Reddy, Vijaya Puttapaka, Yi-Xin Li, Prasanna Sivaprakasam, David Critton, Dawn Mulligan, Chunshan Xie, Radha Ramakrishnan, Jignesh Nagar, Shailesh Dudhgaonkar, Anwar Murtaza, Martins S. Oderinde, Gary L. Schieven, Arvind Mathur, Ashvinikumar V. Gavai, Gregory Vite, Sanjeev Gangwar, Yam B. Poudel
مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Immunology, Cancer, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, synergistic antitumor activity, promising therapeutic agents, phenylpiperidine side chain, gathered considerable interest, novel tlr7 agonists, adme properties culminated, 14 b, vivo <, like properties, 7 agonists, suggesting opportunities, pharmacodynamic profiles, oncology therapies, like receptor, favorable drug, demonstrated excellent, cancer immunotherapy, apd1 antibody, additional refinement
الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00456.s001Test
https://figshare.com/articles/journal_contribution/Identification_and_Optimization_of_Small_Molecule_Pyrazolopyrimidine_TLR7_Agonists_for_Applications_in_Immuno-oncology/24968292Test -
2دورية أكاديمية
المؤلفون: Yam B. Poudel, Liqi He, Matthew Cox, Qian Zhang, Walter L. Johnson, Qiang Cong, Heng Cheng, Naidu S. Chowdari, Christine Tarby, Andrew F. Donnell, Matthais Broekema, Daniel P. O’Malley, Yong Zhang, Murugaiah A. M. Subbaiah, Boda Vijay Kumar, Lakshumanan Subramani, Bei Wang, Yi-Xin Li, Prasanna Sivaprakasam, David Critton, Dawn Mulligan, Bhupindar Sandhu, Chunshan Xie, Radha Ramakrishnan, Jignesh Nagar, Shailesh Dudhgaonkar, Martins S. Oderinde, Anwar Murtaza, Gary L. Schieven, Arvind Mathur, Ashvinikumar V. Gavai, Gregory Vite, Sanjeev Gangwar
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Pharmacology, Biotechnology, Immunology, Cancer, Computational Biology, Chemical Sciences not elsewhere classified, mouse whole blood, complete tumor regression, 26 tumor model, based reporter assay, selective tlr7 agonists, novel tlr7 agonists, tlr7 agonists, developed novel, based designs, vitro <, tnfα cytokines, systemic agent, significant secretion, pharmacodynamic studies, mice showed, intravenous route
الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00455.s001Test
https://figshare.com/articles/journal_contribution/Discovery_of_Novel_TLR7_Agonists_as_Systemic_Agent_for_Combination_With_aPD1_for_Use_in_Immuno-oncology/24961448Test -
3دورية أكاديمية
المؤلفون: Emily C. Cherney (8904614), Liping Zhang (177396), Julian Lo (12035908), Tram Huynh (2093239), Donna Wei (2387248), Vijay Ahuja (7445426), Claude Quesnelle (1601461), Gary L. Schieven (2459572), Alan Futran (9387879), Gregory A. Locke (5941769), Zeyu Lin (2618836), Laura Monereau (12035911), Charu Chaudhry (1655965), Jordan Blum (5347976), Sha Li (145229), Mark Fereshteh (6508499), Bifang Li-Wang (85432), Sanjeev Gangwar (2853356), Chin Pan (2853359), Colin Chong (9368675), Xiao Zhu (257280), Shana L. Posy (1355322), John S. Sack (2375029), Ping Zhang (86495), Max Ruzanov (5877002), Mary Harner (12035914), Fahad Akhtar (12035917), Gretchen M. Schroeder (1551364), Gregory Vite (2853350), Brian Fink (7445429)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Science Policy, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, syngeneic mouse model, intense research due, demonstrate antitumor activity, molecule sting agonists, via <, unique class, tumor immunogenicity, sting agonists, solid tumors, oncology therapy, nucleotide small, interferon genes, currently limited, chemotype hybridization, cdns )
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المؤلفون: Emily C. Cherney, Liping Zhang, Julian Lo, Tram Huynh, Donna Wei, Vijay Ahuja, Claude Quesnelle, Gary L. Schieven, Alan Futran, Gregory A. Locke, Zeyu Lin, Laura Monereau, Charu Chaudhry, Jordan Blum, Sha Li, Mark Fereshteh, Bifang Li-Wang, Sanjeev Gangwar, Chin Pan, Colin Chong, Xiao Zhu, Shana L. Posy, John S. Sack, Ping Zhang, Max Ruzanov, Mary Harner, Fahad Akhtar, Gretchen M. Schroeder, Gregory Vite, Brian Fink
المصدر: Journal of Medicinal Chemistry. 65:3518-3538
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::143c186739969ad25a3e8322819f4602Test
https://doi.org/10.1021/acs.jmedchem.1c01986Test -
5دورية أكاديمية
المؤلفون: Viktor Martyanov, Grace-Hyun J Kim, Wendy Hayes, Shuyan Du, Bishu J Ganguly, Oumar Sy, Sun Ku Lee, Galina S Bogatkevich, Gary L Schieven, Elena Schiopu, Roberta Gonçalves Marangoni, Jonathan Goldin, Michael L Whitfield, John Varga
المصدر: PLoS ONE, Vol 12, Iss 11, p e0187580 (2017)
وصف الملف: electronic resource
العلاقة: http://europepmc.org/articles/PMC5679625?pdf=renderTest; https://doaj.org/toc/1932-6203Test
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المؤلفون: Shana L. Posy, David A Critton, Stefan Ruepp, Ratna Kumar Sreekantha, Laxman Pasunoori, Dharmpal S. Dodd, Murali Subramanian, Andrew Watson, Percy H. Carter, Honghe Wan, Debarati Mazumder Tagore, Paul Davies, Shailesh Dudhgaonkar, Gary L. Schieven, Ratika Srivastava, Luisa Salter-Cid, Michael A. Poss, Alaric J. Dyckman, Mussari Christopher P
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Autoimmune disease, Toll-like receptor, Innate immune system, 010405 organic chemistry, Organic Chemistry, virus diseases, Context (language use), TLR7, Pharmacology, TLR8, Biology, medicine.disease_cause, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, Autoimmunity, 010404 medicinal & biomolecular chemistry, Drug Discovery, medicine, Receptor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85418558e63333c915454e108cc2ef6Test
https://pubmed.ncbi.nlm.nih.gov/32944143Test -
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المؤلفون: Rachael Siegel, Venu Bommireddy, Paget Steven, Albert J. Uveges, Rukiye-Nazan Eraslan, Lee Pellegrino, Krista Saufler, Chia-yu Huang, Eli Mordechai, Haihua Zheng, Gary L. Schieven, Jason Trama, Michael McQueney, Miglena Prabagar, Ku Lu, Axel Metzger, Martin E. Adelson, David Diller, Grant Gallagher, Brian F. Mcguinness, Stanley P. Nawoschik, James R. Beasley
المصدر: Cancer Research. 81:524-524
مصطلحات موضوعية: Agonist, Cancer Research, Sting, Immune system, Bladder cancer, Oncology, business.industry, medicine.drug_class, Cancer research, Medicine, business, Non muscle invasive, medicine.disease
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f9b856e7848effdfb38bf1a76408541eTest
https://doi.org/10.1158/1538-7445.am2021-524Test -
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المؤلفون: Sidney Pitt, John S. Sack, Vicky Tang, William J. Pitts, Steven H. Spergel, Jonathan Lippy, Junqing Guo, Michael Galella, Mertzman Michael E, Sylwia Stachura, Steven G. Nadler, Aberra Fura, Percy H. Carter, Gary L. Schieven, Luisa Salter-Cid, Kim W. McIntyre, James Kempson, Javed Khan, Lauren Haque, Rosemary Zhang, John S. Tokarski, Guoxiang Shen, Kathleen M. Gillooly, Stephen T. Wrobleski, Joel C. Barrish
مصطلحات موضوعية: Tofacitinib, Kinase, business.industry, Organic Chemistry, Prodrug, Pharmacology, medicine.disease, Biochemistry, Immune system, Tyrosine kinase 2, Rheumatoid arthritis, Drug Discovery, Functional selectivity, Medicine, business, Tyrosine kinase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1a959ab8edd802fd477e946d59e0fbTest
https://europepmc.org/articles/PMC6421541Test/ -
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المؤلفون: Hong Wu, Gary L. Schieven, Joel C. Barrish, Bei Wang, Bang Chi Chen, Sam T. Chao, Gerry Everlof, Jung Hui Sun, Chunjian Liu, John H. Dodd, Murray McKinnon, Kathleen M. Gillooly, Katerina Leftheris, John Hynes, Tracy L. Taylor, Vivekananda M. Vrudhula, T. G. Murali Dhar, Stephen T. Wrobleski, Hongjian Zhang, David J. Shuster, Shuqun Lin, Kim W. McIntyre, Rulin Zhao, Christoph Gesenberg, James Lin, Punit Marathe
المصدر: Journal of Medicinal Chemistry. 58:7775-7784
مصطلحات موضوعية: Male, Phenylacetates, Stereochemistry, Phenyl acetate, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Chemistry Techniques, Synthetic, Mitogen-Activated Protein Kinase 14, Rats, Sprague-Dawley, Structure-Activity Relationship, Acetic acid, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Structure–activity relationship, Prodrugs, Protein Kinase Inhibitors, Triazine, Dose-Response Relationship, Drug, Molecular Structure, Prodrug, Arthritis, Experimental, Organophosphates, Macaca fascicularis, Solubility, chemistry, Rats, Inbred Lew, Molecular Medicine, Alkaline phosphatase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8e794014371379532fed83f3d8fff5Test
https://doi.org/10.1021/acs.jmedchem.5b00839Test -
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المؤلفون: Joel C. Barrish, Aberra Fura, Guoxiang Shen, Jingwu Duan, David S. Nirschl, Jonathan Lippy, Stephen T. Wrobleski, Rosemary Zhang, Lidia M. Doweyko, Bingwei V. Yang, Lauren Haque, Murray McKinnon, Shuqun Lin, Luisa Salter-Cid, Sidney Pitt, William J. Pitts, Percy H. Carter, John S. Sack, Gary L. Schieven, Bin Jiang, John Hynes, Gregory D. Brown, John S. Tokarski, Zhonghui Lu, Javed Khan, Steven G. Nadler
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:5721-5726
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, Clinical Biochemistry, Substituent, Administration, Oral, Pharmaceutical Science, Enzyme-Linked Immunosorbent Assay, Biochemistry, Pyrrolopyridazine, Pyridazine, Interferon-gamma, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Functional selectivity, Animals, Humans, Pyrroles, Tissue Distribution, Protein Kinase Inhibitors, Molecular Biology, Whole blood, Mice, Inbred BALB C, Molecular Structure, Organic Chemistry, Janus Kinase 3, Janus Kinase 1, Janus Kinase 2, Pyridazines, chemistry, Tyrosine kinase 2, Molecular Medicine, Amine gas treating, Janus kinase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7f63858a17538ff6a98f0ae52d3f8eTest
https://doi.org/10.1016/j.bmcl.2014.10.061Test