المؤلفون: Atla, Goutham, Bonàs-Guarch, Silvia, Cuenca-Ardura, Mirabai, Beucher, Anthony, Crouch, Daniel J. M., Garcia-Hurtado, Javier, Moran, Ignasi, Consortium, the T2DSystems, Irimia, Manuel, Prasad, Rashmi B., Gloyn, Anna L., Marselli, Lorella, Berney, Thierry, de Koning, Eelco J. P., Kerr-Conte, Julie, Pattou, Francois, Todd, John A., Piemonti, Lorenzo, Ferrer, Jorge

المساهمون: Eliasson, Lena, Creator, Esguerra, Jonathan Lou S., Creator, Groop, Leif, Creator, Mulder, Hindrik, Creator

المصدر: Genome Biology EXODIAB: Excellence of Diabetes Research in Sweden. 23:1-28

مصطلحات موضوعية: Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes

الوصول الحر: https://lup.lub.lu.se/record/d1a3edfa-a90c-4412-8c03-e03b7f2d465aTest
http://dx.doi.org/10.1186/s13059-022-02757-0Test

المؤلفون: Beucher, Anthony, Miguel-Escalada, Irene, Balboa, Diego, De Vas, Matias G., Angel Maestro, Miguel, Garcia-Hurtado, Javier, Bernal, Aina, Gonzalez-Franco, Roser, Vargiu, Pierfrancesco, Heyn, Holger, Ravassard, Philippe, Ortega, Sagrario, Ferrer, Jorge

المساهمون: STEMM - Stem Cells and Metabolism Research Program, Centre of Excellence in Stem Cell Metabolism, Timo Pyry Juhani Otonkoski / Principal Investigator

مصطلحات موضوعية: Set enrichment analysis, Pancreatic beta-cells, Long noncoding rnas, Insulin-secretion, Diabetes-mellitus, Gene, Expression, Chromatin, Phenotypes, Reveals, 3111 Biomedicine, 1182 Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: This research was supported by the Medical Research Council (MR/L02036X/1), Wellcome Trust (WT101033), European Research Council (Advanced Grant 789055), Spanish Ministry of Science and Innovation (BFU2014-54284-R and RTI2018-095666-B-I00) and National Institute for Health Research Imperial Biomedical Research Centre. Work in the Centre for Genomic Regulation was supported by the Centres de Recerca de Catalunya programme, Generalitat de Catalunya, Centro de Excelencia Severo Ochoa (CEX2020-001049) and by the Spanish Ministry of Science and Innovation aid to the European Molecular Biology Laboratory partnership. We thank the University of Barcelona School of Medicine animal facility, Center for Genomic Regulation and Imperial College London genomics units, Imperial College High Performance Computing Service, as well as K. Kaestner (University of Pennsylvania), M. Gannon (Vanderbilt University) and D. Tuveson (Cold Spring Harbor Laboratory) for the Cre lines. We thank J. Valcarcel and T. Graf (Center for Genomic Regulation) for comments on the manuscript, F. X. Real (Spanish National Cancer Research Centre) for insights and support, V. Grau and C. Roth for technical support and members of J.F.’s laboratory for valuable discussions. This research was supported by the Medical Research Council (MR/L02036X/1), Wellcome Trust (WT101033), European Research Council (Advanced Grant 789055), Spanish Ministry of Science and Innovation (BFU2014-54284-R and RTI2018-095666-B-I00) and National Institute for Health Research Imperial Biomedical Research Centre. Work in the Centre for Genomic Regulation was supported by the Centres de Recerca de Catalunya programme, Generalitat de Catalunya, Centro de Excelencia Severo Ochoa (CEX2020-001049) and by the Spanish Ministry of Science and Innovation aid to the European Molecular Biology Laboratory partnership. We thank the University of Barcelona School of Medicine animal facility, Center for Genomic Regulation and Imperial College London genomics units, Imperial College High Performance Computing Service, as well as K. Kaestner (University of Pennsylvania), M. Gannon (Vanderbilt University) and D. Tuveson (Cold Spring Harbor Laboratory) for the Cre lines. We thank J. Valcarcel and T. Graf (Center for Genomic Regulation) for comments on the manuscript, F. X. Real (Spanish National Cancer Research Centre) for insights and support, V. Grau and C. Roth for technical support and members of J.F.’s laboratory for valuable discussions.; Beucher , A , Miguel-Escalada , I , Balboa , D , De Vas , M G , Angel Maestro , M , Garcia-Hurtado , J , Bernal , A , Gonzalez-Franco , R , Vargiu , P , Heyn , H , Ravassard , P , Ortega , S & Ferrer , J 2022 , ' The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A ' , Nature Cell Biology , vol. 24 , no. 10 , pp. 1528-1540 . https://doi.org/10.1038/s41556-022-00996-8Test; 85139519435; b2cda0b6-84e0-40a9-ae45-5be61fdb5877; http://hdl.handle.net/10138/567780Test; 000864585500001

الإتاحة: http://hdl.handle.net/10138/567780Test

المؤلفون: Beucher, Anthony, Miguel-Escalada, Irene, Balboa, Diego, De Vas, Matías G, Maestro, Miguel Angel, Garcia-Hurtado, Javier, Bernal, Aina, Gonzalez-Franco, Roser, Vargiu, Pierfrancesco, Heyn, Holger, Ravassard, Philippe, Ortega, Sagrario, Ferrer, Jorge

المساهمون: UK Research and Innovation, Wellcome Trust, Unión Europea. Comisión Europea. European Research Council (ERC), Ministerio de Ciencia y Universidades (España), NIHR - Imperial Biomedical Research Centre (Reino Unido), Centres de Recerca de Catalunya (CERCA), Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)

مصطلحات موضوعية: Hepatocyte Nuclear Factor 1-alpha, Promoter Regions, Genetic, RNA, Long Noncoding, Animals, Humans, Mice, Mammals, Transcription

العلاقة: https://doi.org/10.1038/s41556-022-00996-8Test.; info:eu-repo/grantAgreement/EC/H2020/789055/EU; info:eu-repo/grantAgreement/ES/BFU2014-54284-R; info:eu-repo/grantAgreement/ES/RTI2018-095666-B-I00; Nat Cell Biol . 2022 ;24(10):1528-1540.; http://hdl.handle.net/20.500.12105/18896Test; Nature cell biology

الإتاحة: https://doi.org/20.500.12105/18896Test
https://doi.org/10.1038/s41556-022-00996-8Test
https://hdl.handle.net/20.500.12105/18896Test

المؤلفون: Miguel-Escalada, Irene, Maestro, Miguel Ángel, Balboa, Diego, Elek, Anamaria, Bernal, Aina, Bernardo, Edgar, Grau, Vanessa, García-Hurtado, Javier, Sebé-Pedrós, Arnau, Ferrer, Jorge

المصدر: Developmental Cell ; volume 57, issue 16, page 1922-1936.e9 ; ISSN 1534-5807

الإتاحة: https://doi.org/10.1016/j.devcel.2022.07.014Test
https://api.elsevier.com/content/article/PII:S1534580722005317?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1534580722005317?httpAccept=text/plainTest

المؤلفون: Akerman, Ildem, Tu, Zhidong, Beucher, Anthony, Rolando, Delphine M Y, Sauty-Colace, Claire, Benazra, Marion, Nakic, Nikolina, Yang, Jialiang, Wang, Huan L., Pasquali, Lorenzo, Moran, Ignasi, Garcia-Hurtado, Javier, Castro, Natalia, Gonzalez-Franco, Roser, Stewart, Andrew F., Bonner, Caroline, Piemonti, Lorenzo, Berney, Thierry, Groop, Leif, Kerr-Conte, Julie, Pattou, Francois, Argmann, Carmen, Schadt, Eric, Ravassard, Philippe, Ferrer, Jorge

المصدر: Cell Metabolism EXODIAB: Excellence of Diabetes Research in Sweden. 25(2):400-411

مصطلحات موضوعية: chromatin, CRISPR interference, diabetes, lncRNAs, long noncoding RNAs, pancreatic islets, PDX1, PLUTO, transcriptional networks, type 2 diabetes, Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes, Medicinska och farmaceutiska grundvetenskaper, Medicinsk genetik, Basic Medicine, Medical Genetics

الوصول الحر: https://lup.lub.lu.se/record/28c0f789-ce8e-46e1-805b-d7d4a577fcfaTest
http://dx.doi.org/10.1016/j.cmet.2016.11.016Test

المؤلفون: Rovira, Meritxell, Atla, Goutham, Maestro, Miguel Angel, Grau, Vanessa, García Hurtado, Javier, Ferrer, Jorge, Maqueda, Maria, Mosquera Mayo, José Luís, Kerr-Conte, Julie, Pattou, Francois

المصدر: Articles publicats en revistes (Ciències Fisiològiques)

مصطلحات موضوعية: Pàncrees, Organogènesi, Biologia molecular, Pancreas, Organogenesis, Molecular biology

وصف الملف: 15 p.; application/pdf

العلاقة: Reproducció del document publicat a: https://doi.org/10.1101/gad.348501.121Test; Genes & Development, 2021, vol. 35, num. 17-18, p. 1229-1243; https://doi.org/10.1101/gad.348501.121Test; info:eu-repo/grantAgreement/EC/H2020/789055/EU//DecodeDiabetes; http://hdl.handle.net/2445/180146Test; 713535

الإتاحة: https://doi.org/10.1101/gad.348501.121Test
http://hdl.handle.net/2445/180146Test

المؤلفون: Akerman, Ildem, Maestro, Miguel Angel, de Franco, Elisa, Grau, Vanessa, Flanagan, Sarah, García-Hurtado, Javier, Mittler, Gerhard, Ravassard, Philippe, Piemonti, Lorenzo, Ellard, Sian, Hattersley, Andrew, T, Ferrer, Jorge

المساهمون: University of Birmingham Birmingham, Centre for Genomic Regulation - Centre de Regulació Genòmica Barcelona (CRG), Universitat Pompeu Fabra Barcelona (UPF)-Centro Nacional de Analisis Genomico Barcelona (CNAG), University of Exeter Medical School, University of Exeter, Max Planck Institute of Immunobiology and Epigenetics (MPI-IE), Max-Planck-Gesellschaft, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), IRCCS Ospedale San Raffaele Milan, Italy

المصدر: ISSN: 2211-1247.

مصطلحات موضوعية: GLIS3, HIP, INS promoter, mouse model, neonatal diabetes, regulatory element, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33852861; hal-03231925; https://hal.sorbonne-universite.fr/hal-03231925Test; https://hal.sorbonne-universite.fr/hal-03231925/documentTest; https://hal.sorbonne-universite.fr/hal-03231925/file/1-s2.0-S2211124721002953-main.pdfTest; PUBMED: 33852861; PUBMEDCENTRAL: PMC8052186

الإتاحة: https://doi.org/10.1016/j.celrep.2021.108981Test
https://hal.sorbonne-universite.fr/hal-03231925Test
https://hal.sorbonne-universite.fr/hal-03231925/documentTest
https://hal.sorbonne-universite.fr/hal-03231925/file/1-s2.0-S2211124721002953-main.pdfTest

المؤلفون: Miguel-Escalada, Irene, Bonas-Guarch, Silvia, Cebola, Ines, Ponsa-Cobas, Joan, Mendieta-Esteban, Julen, Atla, Goutham, Javierre, Biola M., Rolando, Delphine M. Y., Farabella, Irene, Morgan, Claire C., Garcia-Hurtado, Javier, Beucher, Anthony, Moran, Ignasi, Pasquali, Lorenzo, Ramos-Rodriguez, Mireia, Appel, Emil V. R., Linneberg, Allan, Gjesing, Anette P., Witte, Daniel R., Pedersen, Oluf, Grarup, Niels, Ravassard, Philippe, Torrents, David, Mercader, Josep M., Piemonti, Lorenzo, Berney, Thierry, de Koning, Eelco J. P., Kerr-Conte, Julie, Pattou, Francois, Fedko, Iryna O., Groop, Leif, Prokopenko, Inga, Hansen, Torben, Marti-Renom, Marc A., Fraser, Peter, Ferrer, Jorge

المصدر: Miguel-Escalada , I , Bonas-Guarch , S , Cebola , I , Ponsa-Cobas , J , Mendieta-Esteban , J , Atla , G , Javierre , B M , Rolando , D M Y , Farabella , I , Morgan , C C , Garcia-Hurtado , J , Beucher , A , Moran , I , Pasquali , L , Ramos-Rodriguez , M , Appel , E V R , Linneberg , A , Gjesing , A P , Witte , D R , Pedersen , O , Grarup , N , Ravassard , P , Torrents , D ....

مصطلحات موضوعية: GENOME-WIDE ASSOCIATION, SUPER-ENHANCERS, READ ALIGNMENT, CELL IDENTITY, RISK, TCF7L2, TRANSCRIPTION, MECHANISMS, EXPRESSION, VARIANTS

العلاقة: https://pure.au.dk/portal/en/publications/32790ad4-efb3-45b0-830f-3a95cc537db9Test

الإتاحة: https://doi.org/10.1038/s41588-019-0457-0Test
https://pure.au.dk/portal/en/publications/32790ad4-efb3-45b0-830f-3a95cc537db9Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640048/pdf/EMS83553.pdfTest

المؤلفون: Goutham Atla, Bonàs-Guarch, Sílvia, Cuenca-Ardura, Mirabai, Beucher, Anthony, Crouch, Daniel J.M., Garcia-Hurtado, Javier, Moran, Ignasi, T2DSystems Consortium, Irimia, Manuel, Prasad, Rashmi B, Gloyn, Anna L., Marselli, Lorella, Suleiman, Mara, Berney, Thierry, De Koning, Eelco J P, Kerr-Conte, Julie, Pattou, Francois, Todd, John A., Piemonti, Lorenzo, Ferrer, Jorge

المساهمون: Atla, Goutham, Bonàs-Guarch, Silvia, Cuenca-Ardura, Mirabai, Beucher, Anthony, Crouch, Daniel J M, Garcia-Hurtado, Javier, Moran, Ignasi, Irimia, Manuel, Prasad, Rashmi B, Gloyn, Anna L, Marselli, Lorella, Suleiman, Mara, Berney, Thierry, de Koning, Eelco J P, Kerr-Conte, Julie, Pattou, Francoi, Todd, John A, Piemonti, Lorenzo, Ferrer, Jorge, Barcelona Supercomputing Center, Wellcome Trust, Imperial College Healthcare NHS Trust- BRC Funding, Medical Research Council (MRC)

المصدر: Genome Biology, 23(1). BMC

مصطلحات موضوعية: Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC], Quantitative trait loci, RNA splicing, Bioinformatics, Diabetes pathophysiology, 05 Environmental Sciences, Pancreatic islets, G-protein signaling, TWAS, Senescence, CTRB2, Islets of Langerhans, Humans, Protein Isoforms, T2D, eQTLs, Diabetes, Beta cells, Type 2 diabetes, 06 Biological Sciences, Pancreatic beta-cells, Beta cell, Type 1 diabetes, Exodeoxyribonucleases, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, RNA, Long Noncoding, 08 Information and Computing Sciences, sQTLs, T2DSystems Consortium, Genètica, Proinsulin

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ba51d68d0691d8cec835aeed964415Test

المؤلفون: Akerman, Ildem, Tu, Zhidong, Beucher, Anthony, Rolando, Delphine M. Y., Sauty-Colace, Claire, Benazra, Marion, Nakic, Nikolina, Yang, Jialiang, Wang, Huan, Pasquali, Lorenzo, Moran, Ignasi, Garcia Hurtado, Javier, Castro, Natalia, Gonzalez Franco, Roser, Stewart, Andrew F., Bonner, Caroline, Piemonti, Lorenzo, Berney, Thierry, Groop, Leif, Kerr-Conte, Julie, Pattou, Francois, Argmann, Carmen, Schadt, Eric, Ravassard, Phillipe, Ferrer, Jorge, Universitat Autònoma de Barcelona

وصف الملف: application/pdf

العلاقة: European Commission 667191; Ministerio de Economía y Competitividad FU2014-54284-R; Cell metabolism; Vol. 25 (february 2017), p. 400-411; https://ddd.uab.cat/record/196584Test; urn:10.1016/j.cmet.2016.11.016; urn:oai:ddd.uab.cat:196584; urn:pmid:28041957; urn:scopus_id:85009909783; urn:wos_id:000396354400020; urn:altmetric_id:15130880; urn:pmc-uid:5300904; urn:pmcid:PMC5300904; urn:oai:pubmedcentral.nih.gov:5300904

الإتاحة: https://ddd.uab.cat/record/196584Test