دورية أكاديمية
Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats.
| العنوان: | Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. |
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| المؤلفون: | Hilbert, P, Lindpaintner, K, Beckmann, J S, Serikawa, T, Soubrier, F, Dubay, C, Cartwright, P, De Gouyon, B, Julier, C, Takahasi, S, Vincent, M, Gante, D, Georges, Michel, Lathrop, G.M. |
| المصدر: | Nature, 353 (6344), 521 - 529 (1991-10-10) |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 1991 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Receptors, Cell Surface, Nerve Growth Factor, Somatotropin, Peptidyl-Dipeptidase A, Animals, Base Sequence, Chromosome Mapping, Genetic Linkage, Hypertension/genetics, Molecular Sequence Data, Peptidyl-Dipeptidase A/genetics, Polymerase Chain Reaction, Rats, Inbred SHR/genetics, Inbred WKY/genetics, Cell Surface/genetics, Somatotropin/genetics, X Chromosome, Multidisciplinary, Life sciences, Genetics & genetic processes, Sciences du vivant, Génétique & processus génétiques |
| الوصف: | peer reviewed ; The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneously hypertensive rat and the normotensive control strain Wistar-Kyoto have led to the localization of two genes, BP/SP-1 and BP/SP-2, that contribute significantly to blood pressure variation in the F2 population. BP/SP-1 and BP/SP-2 were assigned to rat chromosomes 10 and X, respectively. Comparison of the human and rat genetic maps indicates that BP/SP-1 could reside on human chromosome 17q in a region that also contains the angiotensin I-converting enzyme gene (ACE). This encodes a key enzyme of the renin-angiotensin system, and is therefore a candidate gene in primary hypertension. A rat microsatellite marker of ACE was mapped to rat chromosome 10 within the region containing BP/SP-1. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0028-0836 1476-4687 |
| العلاقة: | http://www.nature.com/articles/353521a0Test; urn:issn:0028-0836; urn:issn:1476-4687; https://orbi.uliege.be/handle/2268/309563Test; info:hdl:2268/309563; scopus-id:2-s2.0-0025946420; info:pmid:1656270 |
| DOI: | 10.1038/353521a0 |
| الإتاحة: | https://doi.org/10.1038/353521a0Test https://orbi.uliege.be/handle/2268/309563Test |
| رقم الانضمام: | edsbas.9289DF74 |
| قاعدة البيانات: | BASE |
| تدمد: | 00280836 14764687 |
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| DOI: | 10.1038/353521a0 |