التفاصيل البيبلوغرافية
| العنوان: |
Optical coherence tomography (OCT) and OCT-angiography in syndromic versus non-syndromic USH2A -associated retinopathy |
| المؤلفون: |
Antropoli, Alessio, Arrigo, Alessandro, Caprara, Carlo, Bianco, Lorenzo, Mercuri, Stefano, Berni, Alessandro, Passerini, Ilaria, Gambarotta, Sofia, Sodi, Andrea, Bandello, Francesco, Murro, Vittoria, Parodi, Maurizio Battaglia |
| المساهمون: |
Ministero della Salute |
| المصدر: |
European Journal of Ophthalmology ; ISSN 1120-6721 1724-6016 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Ophthalmology, General Medicine |
| الوصف: |
Purpose To compare non-syndromic and syndromic forms of USH2A-related retinitis pigmentosa (RP) by means of structural optical coherence tomography (OCT) and OCT-angiography (OCTA). Methods Observational, cross-sectional, multicenter study. All patients underwent best corrected visual acuity (BCVA) measurement, OCT (Spectralis HRA + OCT, Heidelberg Engineering) and OCTA (OCT DRI Topcon Triton, Topcon Corporation). We compared subfoveal choroidal thickness (SCT), choroidal vascularity index (CVI), presence of cystroid macular edema (CME), macular vessel density (VD) at the superficial and deep capillary plexa, as well as VD of the radial peripapillary capillary (RPC) network, between syndromic and non-syndromic patients with USH2A-associated retinopathy. Results Thirty-four eyes from 18 patients (7 females) were included. Thirteen patients (72.2%) were affected by Usher syndrome type 2, whereas the remaining 5 subjects (27.8%) had non-syndromic retinitis pigmentosa (nsRP). Syndromic patients were younger than nsRP ( p = 0.01) and had a worse visual acuity than those with the exclusively retinal phenotype. Patients with Usher syndrome type 2 had a higher prevalence of CME and a thicker choroid compared to nsRP, although these results were not statistically significant ( p = 0.775 and p = 0.122, respectively). Similarly, none of the other quantitative OCT and OCTA parameters was statistically different between the two groups. Conclusions Despite their younger age, patients with Usher syndrome type 2 displayed similar choroidal and microvascular changes compared to those with nsRP. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1177/11206721241247421 |
| الإتاحة: |
https://doi.org/10.1177/11206721241247421Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.F88598E5 |
| قاعدة البيانات: |
BASE |
