المؤلفون: Gregory O. Austin, Alejandra Tomas

المصدر: Frontiers in Molecular Biosciences, Vol 10 (2023)

مصطلحات موضوعية: incretin—based therapy, GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), T2D (type 2 diabetes), obesity, incretin receptors, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmolb.2023.1170181/fullTest; https://doaj.org/toc/2296-889XTest

الوصول الحر: https://doaj.org/article/25fff138d7bd4f0ea275f6014162aa29Test

المؤلفون: Shweta Urva, Julie S. Moyers, Krister Bokvist, Kyle W. Sloop, Jorge Alsina-Fernandez, William C. Roell, Charles Benson, Uma Kuchibhotla, David A. D'Alessio, Corina Loghin, Xuewei Cui, Tamer Coskun, Over Cabrera, Daniel A. Briere, Ruth E. Gimeno, Axel Haupt

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 18, Iss, Pp 3-14 (2018)

مصطلحات موضوعية: 0301 basic medicine, ipGTT, Intraperitoneal glucose tolerance test, LY3298176, ADA, Antidrug antibodies, Receptor agonist activity, Pharmacology, 0302 clinical medicine, Glucagon-Like Peptide 1, Medicine, OGTT, Oral glucose tolerance test, Receptor, T2DM, Type 2 diabetes mellitus, CNS, Central nervous system, ECG, Electrocardiogram, SMBG, Self-monitored blood glucose, Glucagon-like peptide-1, SAD, Single-ascending dose, LY, LY3298176, Original Article, medicine.drug, Agonist, POC, Proof-of-concept, lcsh:Internal medicine, Glucose-dependent insulinotropic polypeptide, medicine.drug_class, Incretin, 030209 endocrinology & metabolism, GLP-1 RA, Glucagon-like peptide-1 receptor agonist, Incretins, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Metabolic Diseases, PL, PPlacebo, Diabetes mellitus, Type 2 diabetes mellitus, Humans, DU, Dulaglutide, Obesity, GIP, Glucose-dependent insulinotropic polypeptide, lcsh:RC31-1245, Molecular Biology, MAD, Multiple-ascending dose, Glucagon-like peptide 1 receptor, business.industry, CI, Confidence interval, Cell Biology, medicine.disease, DIO, Diet-induced obesity, 030104 developmental biology, HS, Healthy subjects, Diabetes Mellitus, Type 2, MMRM, Mixed model for repeated measures, Dulaglutide, business, LSM, Least square mean

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ca485dc3a86e98e8a5c2fbb364cd27Test
http://europepmc.org/articles/PMC6308032Test

المؤلفون: Emma Rose McGlone, Alejandra Tomas, Sunil Kumar, Zijian Fang, Ben Jones, Paul M. W. French, Stephen R. Bloom, Phil Pickford, Christopher Dunsby, Asuka Inoue, Tricia Tan, Ivan R. Corrêa, Frederik Görlitz, Ralf Jockers, Guy A. Rutter, Atsuro Oishi

المساهمون: Imperial College Healthcare NHS Trust- BRC Funding, Medical Research Council (MRC), The Academy of Medical Sciences, Society for Endocrinology, European Foundation for the Study of Diabetes, British Society for Neuroendocrinology, Wellcome Trust

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Ligands, Biochemistry, Mice, Glucagon-Like Peptide 1, Insulin Secretion, DPP-4, dipeptidyl dipeptidase-4, Functional selectivity, Cyclic AMP, Receptor, beta-Arrestins, 11 Medical and Health Sciences, GIP, diabetes, Chemistry, membrane trafficking, GIP, glucose-dependent insulinotropic polypeptide, GLP-1, glucagon-like peptide-1, incretin, GCGR, glucagon receptor, biased agonism, receptor endocytosis, 03 Chemical Sciences, Signal Transduction, Research Article, Agonist, medicine.medical_specialty, Biochemistry & Molecular Biology, GIPR, glucose-dependent insulinotropic polypeptide receptor, medicine.drug_class, GPCR, G protein–coupled receptors, Incretin, T2D, type 2 diabetes, Gastric Inhibitory Polypeptide, Incretins, Glucagon-Like Peptide-1 Receptor, Receptors, Gastrointestinal Hormone, 03 medical and health sciences, Downregulation and upregulation, DERET, diffusion-enhanced resonance energy transfer, trafficking, Internal medicine, medicine, Arrestin, Animals, Humans, Molecular Biology, GCG, glucagon, G protein-coupled receptor, 030102 biochemistry & molecular biology, β-arrestin, molecular pharmacology, Cell Biology, 06 Biological Sciences, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, HEK293 Cells, glucagon, MAPK, mitogen-activated protein kinases, PKA, protein kinase A, GLP-1, Glucagon receptor, GLP-1R, glucagon-like peptide-1 receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14471befc4ee6d914cdba212a163e9f9Test
http://hdl.handle.net/10044/1/85112Test

المؤلفون: Bolette Hartmann, Geke Aline Boer, Jens J. Holst

المصدر: Boer, G A, Hartmann, B & Holst, J J 2021, ' Pharmacokinetics of exogenous GIP(1-42) in C57Bl/6 mice; Extremely rapid degradation but marked variation between available assays ', Peptides, vol. 136, 170457 . https://doi.org/10.1016/j.peptides.2020.170457Test
Peptides

مصطلحات موضوعية: Blood Glucose, C57BL/6, DDP-4, Physiology, medicine.medical_treatment, Peptide, Biochemistry, Mice, 0302 clinical medicine, Endocrinology, Glucagon-Like Peptide 1, GIP ELISA, chemistry.chemical_classification, GIP, biology, Chemistry, Area under the curve, GIP, glucose-dependent insulinotropic polypeptide, ELISA, enzyme-linked immunosorbent assay, Female, IP, intraperitoneal, IV, intravenous, hormones, hormone substitutes, and hormone antagonists, endocrine system, medicine.medical_specialty, Peptide degradation, Dipeptidyl Peptidase 4, Intraperitoneal injection, 030209 endocrinology & metabolism, Gastric Inhibitory Polypeptide, Peptide hormone, Article, Receptors, Gastrointestinal Hormone, 03 medical and health sciences, Cellular and Molecular Neuroscience, Pharmacokinetics, In vivo, Internal medicine, medicine, Animals, Humans, Hypoglycemic Agents, GPCR, G protein-coupled receptor, Dipeptidyl-Peptidase IV Inhibitors, GIPR, glucose-dependent insulinotropic polypeptide receptor DPP-4, dipeptidyl peptidase-4, Glucagon, biology.organism_classification, Hypoglycemia, Peptide Fragments, In vitro, SC, subcutaneous, RIA, radioimmunoassays, Proteolysis, PC1/3, prohormone convertase 1/3, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd99fcf12f35936ea56b7da4adfeb61Test
https://doi.org/10.1016/j.peptides.2020.170457Test

المؤلفون: Danielle I. McCarthy, Rosalind J. Miller, Leanne Smith, Jonathan A. Farrimond, Monica L Castro-Acosta, Wendy L. Hall

المصدر: The Journal of Nutritional Biochemistry
Acosta, M L C, Smith, L, Miller, R J, McCarthy, D I, Farrimond, J A & Hall, W L 2016, ' Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations ', JOURNAL OF NUTRITIONAL BIOCHEMISTRY, vol. 38, pp. 154-161 . https://doi.org/10.1016/j.jnutbio.2016.09.002Test

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, Tmax, Time of maximum concentration, medicine.medical_treatment, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Biochemistry, Anthocyanins, chemistry.chemical_compound, Diet, Carbohydrate-Restricted, Ribes, CON, Control treatment, Functional Food, Insulin, NEFA, Non-esterified fatty acids, GLP-1, Glucagon-like peptide-1, M-BE, Medium dose off blackcurrant extract, Meals, TAG, Triacylglycerol, Meal, Cross-Over Studies, Nutrition and Dietetics, DVP-RI, Digital volume pulse reflection index, Berries, Postprandial glycemia, Middle Aged, Postprandial Period, Glucagon-like peptide-1, Clinical trial, Postprandial, Randomized controlled trial, AOB, Area over baseline, Female, Diet, Carbohydrate Loading, Research Article, Adult, medicine.medical_specialty, Incretin, Incretins, Beverages, 03 medical and health sciences, NEFA, Double-Blind Method, L-BE, Low dose of blackcurrant extract, Internal medicine, Hyperinsulinism, medicine, Cmax, Maximum concentration, Humans, Hypoglycemic Agents, GIP, Glucose-dependent insulinotropic polypeptide, Healthy volunteers, Molecular Biology, 030109 nutrition & dietetics, Plant Extracts, Polyphenols, Crossover study, Endocrinology, Glucose, chemistry, Anthocyanin, Fruit, Hyperglycemia, H-BE, High dose of blackcurrant extract, DVP-SI, Digital volume pulse stiffness index

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43673c33f67fb3816787571fd0679dffTest

المؤلفون: Masakazu Haneda, Masami Chin-Kanasaki, Satoshi Ugi, Yukihiro Fujita, Tsuyoshi Yanagimachi, Shinji Kume, Keiko Kondo, Takashi Uzu, Sawako Kitahara, Shin-ich Araki, Hisazumi Araki, Shiro Maeda, Daisuke Koya, Akihiro Sekine, Atsunori Kashiwagi, Motoyuki Kondo, Hiroshi Maegawa, Kiyosumi Maeda, Yoshihiko Nishio

المصدر: EBioMedicine
EBioMedicine, Vol 13, Iss C, Pp 168-180 (2016)

مصطلحات موضوعية: 0301 basic medicine, SNS, sympathetic nervous system, Male, Sympathetic Nervous System, Time Factors, 18F-FDG, 2-[fluorine-18]-2-deoxy-d-glucose, OGTT, oral glucose tolerance test, Insulins, lcsh:Medicine, Type 2 diabetes, AMP-Activated Protein Kinases, ACC, acetyl CoA carboxylase, IPITT, intraperitoneal insulin tolerance test, chemistry.chemical_compound, 0302 clinical medicine, AMP-activated protein kinase, Insulin-Secreting Cells, Pancreatic β cell, Kg, glucose disappearance rate, lcsh:R5-920, biology, Insulin secretion, Diabetes, GIP, glucose-dependent insulinotropic polypeptide, LETO, Long-Evans Tokushima Otsuka, Brain, GLP-1, glucagon-like peptide-1, General Medicine, Fasting, Glucagon-like peptide-1, Denervation, CT, computed tomography, Organ Specificity, OLETF, Otsuka Long-Evans Tokushima Fatty, SNPs, single nucleotide polymorphisms, First-phase GSIS, lcsh:Medicine (General), Research Paper, Cell physiology, HOMA-β, homeostasis model assessment beta-cell function index, medicine.medical_specialty, endocrine system, FSIVGTT, frequently sampled intravenous glucose tolerance test, SUV, standardized uptake value, Hypothalamus, 2-DG, 2-deoxy-d-glucose, General Biochemistry, Genetics and Molecular Biology, PET, positron emission tomography, AIR, acute insulin response, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, Fluorodeoxyglucose F18, Internal medicine, Diabetes mellitus, medicine, Animals, Humans, Secretion, Protein kinase A, Pancreas, ICV, intracerebroventricular, business.industry, lcsh:R, SD, Sprague-Dawley, AICAR, 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside, PNx, pancreatic denervation, Glucose Tolerance Test, medicine.disease, Rats, AMPK, AMP-activated protein kinase, Disease Models, Animal, 030104 developmental biology, Endocrinology, Glucose, chemistry, Diabetes Mellitus, Type 2, Starvation, Positron-Emission Tomography, biology.protein, business, 2-Deoxy-D-glucose, Tomography, X-Ray Computed, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d014db160e4a33e174aa6aa14da1f82Test
http://europepmc.org/articles/PMC5264491Test

المؤلفون: Sandra Hummel, Andreas Beyerlein, Markus Pfirrmann, Anna Hofelich, Daniela Much, Susanne Hivner, Melanie Bunk, Melanie Herbst, Claudia Peplow, Markus Walter, Denise Kohn, Nadine Hummel, Jürgen Kratzsch, Michael Hummel, Martin Füchtenbusch, Joerg Hasford, Anette-G. Ziegler, Heike Börschmann, Sophia Ebe, Eleni Giannopoulou, Minna Harsunen, Veronika Hofbauer, Andrea Schuppenies, Maike Wallner, David Wiesenäcker, Stephanie Zillmer, Lorenz Lachmann, Rüdiger Landgraf, Karl-Theo Maria Schneider, Elisabeth André, Viktoria Janke, Ezio Bonifacio

المصدر: Mol. Metab. 9, 168-175 (2018)
Molecular Metabolism
Molecular Metabolism, Vol 9, Iss, Pp 168-175 (2018)

مصطلحات موضوعية: endocrine system diseases, Placebo-controlled study, Dipeptidyl peptidase-4 inhibitor, 030204 cardiovascular system & hematology, DPP4 inhibitor, dipeptidyl peptidase-4 inhibitor, Gestational diabetes mellitus, Impaired glucose tolerance, 0302 clinical medicine, Pregnancy, IGT, impaired glucose tolerance, Medicine, Vildagliptin, GLP-1, Glucagon-like peptide-1, ITT, intention-to-treat, Postpartum Period, GIP, glucose-dependent insulinotropic polypeptide, Gestational Diabetes Mellitus, Prevention, Dipeptidyl Peptidase-4 Inhibitor, Postpartum Diabetes, Randomized Controlled Trial, Life-style, 3. Good health, Gestational diabetes, Randomized controlled trial, Original Article, Female, medicine.drug, Adult, lcsh:Internal medicine, medicine.medical_specialty, 030209 endocrinology & metabolism, Placebo, 03 medical and health sciences, Double-Blind Method, Diabetes mellitus, Internal medicine, Humans, Hypoglycemic Agents, lcsh:RC31-1245, Molecular Biology, IFG, impaired fasting glucose, GDM, gestational diabetes mellitus, business.industry, nutritional and metabolic diseases, Cell Biology, medicine.disease, Impaired fasting glucose, Diabetes, Gestational, Postpartum diabetes, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca785678808643ae1220d096f5c2a7bbTest
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=52883Test

المؤلفون: Miriam Cnop, Sanna Toivonen, Paraskevi Salpea, Mariana Igoillo-Esteve

المصدر: Molecular metabolism, 6 (9
Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 9, Pp 1024-1039 (2017)

مصطلحات موضوعية: 0301 basic medicine, Obstétrique, IAPP, islet amyloid polypeptide, uORF, upstream open reading frame, PERK, PKR-like ER kinase, Cell, Eukaryotic Initiation Factor-2, Apoptosis, PBA, 4-phenyl butyric acid, Review, hESC, human embryonic stem cell, Endoplasmic Reticulum, ATF, activating transcription factor, ERAD, ER-associated degradation, eIF-2 Kinase, UPR, unfolded protein response, Gynécologie, Insulin-Secreting Cells, GCN2, general control non-derepressible-2, hiPSC, human induced pluripotent stem cell, Insulin, Pancreatic β cell, Phosphorylation, IER3IP1, immediate early response-3 interacting protein-1, Cell Death, Chemistry, MEHMO, mental retardation, epilepsy, hypogonadism and -genitalism, microcephaly and obesity, Diabetes, GIP, glucose-dependent insulinotropic polypeptide, TUDCA, taurine-conjugated ursodeoxycholic acid derivative, CReP, constitutive repressor of eIF2α phosphorylation, NRF2, nuclear factor, erythroid 2 like 2, Endoplasmic Reticulum Stress, SERCA, sarcoendoplasmic reticulum Ca2+ ATPase, 3. Good health, PP1, protein phosphatase 1, WFS, Wolfram syndrome, medicine.anatomical_structure, XBP1, X-box binding protein 1, CRISPR, clustered regularly interspaced short palindromic repeats, Endoplasmic reticulum stress, PDX1, Signal transduction, Signal Transduction, IRE1, inositol-requiring protein-1, Islet, lcsh:Internal medicine, medicine.medical_specialty, Programmed cell death, SERCA, XBP1, eIF2α, CHOP, C/EBP homologous protein, eIF2, eukaryotic translation initiation factor 2, ER, endoplasmic reticulum, 03 medical and health sciences, Internal medicine, medicine, Diabetes Mellitus, Animals, Humans, HRI, heme-regulated inhibitor kinase, GLP-1, glucagon-like peptide 1, PPA, phenylpropenoic acid glucoside, lcsh:RC31-1245, GWAS, genome-wide association study, Molecular Biology, PKR, protein kinase RNA, ISR, integrated stress response, RyR2, type 2 ryanodine receptor/Ca2+ release channel, Endoplasmic reticulum, Cell Biology, Pdx1, pancreatic duodenal homeobox 1, 030104 developmental biology, Endocrinology, hPSC, human pluripotent stem cell, Cancer research, Unfolded protein response, Unfolded Protein Response, RIDD, regulated IRE1-dependent decay, Biologie cellulaire, MODY, maturity-onset diabetes of the young, HNF1A, hepatocyte nuclear factor 1-α

وصف الملف: 1 full-text file(s): application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7053c5ccd97e2ddd29e8ceb63030b041Test
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/259114Test

المؤلفون: Hirosato, Mashima, Noboru, Watanabe, Masanari, Sekine, Satohiro, Matsumoto, Takeharu, Asano, Kazuhito, Yuhashi, Noriyoshi, Sagihara, Shunsuke, Urayoshi, Takeshi, Uehara, Junichi, Fujiwara, Takehiro, Ishii, Rumiko, Tsuboi, Hiroyuki, Miyatani, Hirohide, Ohnishi

المصدر: Biochemistry and Biophysics Reports

مصطلحات موضوعية: Wnt/β-catenin, Notch, Atoh1, atonal homolog 1, ACh, acetylcholine, HE, hematoxylin and eosin, CCK2R, cholecystokinin-2 receptor, qPCR, quantitative real-time PCR, Proliferation, CCK, cholecystokinin, GIP, glucose-dependent insulinotropic polypeptide, Tcf1, T-cell factor 1, VIP, vasoactive intestinal peptide, Ab, antibody, TA, transit amplifying, IEC, intestinal epithelial cell, GPCR, G-protein coupled receptor, DKO, double knock-out, GLP-1, glucagon-like-peptide-1, Gα11, siRNA, small interfering RNA, NICD, Notch1 intracellular cytoplasmic domain, Enterocyte, mAChR, muscarinic acetylcholine receptor, Gαq, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::35e356bf3472af2a120ff894ff223f64Test
https://pubmed.ncbi.nlm.nih.gov/29387814Test

المؤلفون: Anna Gruca, Philip C. Calder, Aldona Dembinska-Kiec, Maria Kapusta, Krystyna Slowinska-Solnica, Caroline E. Childs, D. Wnek, Urszula Razny, Joanna Góralska, Małgorzata Malczewska-Malec, Beata Kieć-Wilk, Anna Polus, Anna Zdzienicka

المصدر: BBA Clinical

مصطلحات موضوعية: eicosapentaenoic acid, obesity, medicine.medical_specialty, Eicosapentaenoic acid, medicine.medical_treatment, BMI, body mass index, OGTT, oral glucose tolerance test, NEFA, non esterified fatty acids, Caloric restriction, DHA, docosahexaenoic acid, AUC, area under curve, Pathology and Forensic Medicine, chemistry.chemical_compound, PC, phosphatidylcholine, NEFA, Insulin resistance, insulin resistance, Physiology (medical), Internal medicine, medicine, Obesity, PUFA, polyunsaturated fatty acids, 2. Zero hunger, chemistry.chemical_classification, GIP, glucose dependent insulinotropic polypeptide, business.industry, Insulin, IGI, insulinogenic index, Regular Article, docosahexaenoic acid, medicine.disease, EPA, eicosapentaenoic acid, n-3 polyunsaturated fatty acids, Docosahexaenoic acid, Endocrinology, chemistry, Molecular Medicine, lipids (amino acids, peptides, and proteins), caloric restriction, Docosapentaenoic acid, business, Body mass index, OGIS, oral glucose insulin sensitivity index, hormones, hormone substitutes, and hormone antagonists, Polyunsaturated fatty acid

وصف الملف: text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04c979601801ea289710e2cf45938eaTest
http://europepmc.org/articles/PMC4737910Test