التفاصيل البيبلوغرافية
| العنوان: |
Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial |
| المؤلفون: |
HC Gerstein, S Yusuf, RR Holman, J Bosch, S Anand, A Avezum, A Budaj, J Chiasson, I Conget, G Dagenais, M Davis, R Diaz, N Dinccag, M Enjalbert, A Escalante, G Fodor, M Hanefeld, T Hedner, K Jolly, M Keltai, M Laakso, F Lanas, E Lonn, M McQueen, V Mohan, A Phillips, L Piegas, V Pirags, J Probstfield, J Shaw, I Schmid, K Teo, P Zimmet, B Zinman, J Pogue, P Sheridan, B Hoogwerf, R Ahuad Guerrero, J Albisu, MS Alvarez, V Arregui, H Avaca, H Baglivo, M Balbuena, F Bello, J Bono, M Botto, L Brandani, M Brandes, D Bruera, R Cabral Venere, A Caccavo, A Cacurri, G Caime, M Capozzi, A Carrique, P Carrique, L Cartasegna, J Casabe, G Casaccia, C Castellanos, L Castro, G Cendali, P Cerchi, M Cerdan, M Cinalli, M Cipullo, M Cismondi, N Citta, L Citta, C Crespo, P Crunger, C Cuneo, L De Loredo, S De Loredo, S del Cerro, R Denaro, E Esperatti, L Esposito, H Farras, A Fernandez, M Fernandez, S Fernandez, G Ferrari, M Focaccia, L Frontini, A Gabito, A Gambarte, M Garrido, I Garrido, V Guglielmotti, A Hershson, V Hoffman, G Juarisit, M Klyver, M Lagrutta, A Liberman, J Llanos, L Lobo Marquez, R Lopez, D Lowenstein, J Lowenstein, C Lucero, H Luciardi, E Luduena Clos, M Luna, C Luquez, I MacKinnon, M Maffia, C Mahfoud, C Majul, N Maldonado, O Manuale, G Marcucci, S Martin, G Martinez, M Martos, E Marzetti, R Memoli, M Molina, O Montana, S Morales, Y Morell, S Navarrete, F Nieto, L Ocampo, R Orce, A Orlandini, E Oteiza, C Pepa, J Piasentin, D Piskorz, M Plastino, J Pomposiello, G Quiroga, F Ramos, H Ramos, F Reissig, A Risolo, Z Riverso, H Rodrigues, C Rodriquez, S Saavedra, L Sago, R Sanchez, C Schwindt, P Schygiel, F Sebastian, G Sposetti, P Streitenberger, G Suarez, F Suzrez, M Vico, S Vignau, V Visco, A Vizcaya Castro, C Zaidman, C Allen, T Arsov, N Bartlett, B Batrouney, R Borger, B Brooks, P Buchanan, A Buckland, D Calvert, J Carr, Y Chan, H Ching, A Chronopoulos, P Coates, N Cohen, S Colagiuri, P Colman, M Correcha, M d'Emden, G Ding, W Edwards, K Estensen, B Fitzpatrick, J Freeborn, H Friebel, G Fulcher, C Garland, A Gauld, J Gein, C Glatthaar, J Graham, A Gronan, A Gunser, P Hackney, C Hall, L Hay, V Heazlewood, D Heyward, B Higgins, M Hines, A Hodge, S Honisett, A Jovanovska, J Karrasch, M Kean, M Lawton, C Lee, H Legg, F Long, E Lucas, L Lynch, A Marangou, F Margrie, L Martin, J McKenzie, A McKinnon, M McNamara, J Mencel, R Moses, C Murphy, V Naidu, J Nairn, A Nankervis, N Nattrass, A Ngweso, T Nugent, R O'Brien, N Palmer, H Parry, K Pasculli, P Patrikios, S Perampalam, J Phillips, S Phillips, E Por, S Pringle, E Prior, J Proietto, L Rando, D Ridley, A Roberts, P Robertson, K Robinson, C Rodgers, G Ross, J Rowe, R Siddall, D Silva, R Simpson, R Slobodniuk, G Smith, L Socha, V Soden, M Speedy, E Spence, K Steed, C Stephens, R Stewart, B Stuckey, P Sumithran, J Sunderland, E Tapp, N Tejani, C Tong, D Topliss, H Tran, S Vanlint, J Wagner, J Walsh, J Warner, A Webb, T Welborn, J Wentworth, C White, S Wigg, V Willenberg, D Wilson, M Wood, S Wu, D Yue, R Yuen, S Marshall E Baillie, G Campbell, J Cressall, J Heir, D Jones, J Myrie, M Watlington, A West, M Bertolami, J Borges, D Branco de Araujo, L Cartena, N de Campos Salvarani, A Faludi, D Fernades Telo, S Grespan, J Gross, A Halpern, A Hirota, S Maeda, O Monte, Y Nakamura, J Nunes Salles, O Oliveira, C Pinto, L Rabelo, A Rabelo, S Silveiro, L Turatti, H Zatz, V Zoubel, C Abbott, A Abu-Bakare, R Allison, T Anderlic, D Auger, A Barnie, J Beauchef, S Beers, L Beliveau, L Berard, H Bolduc, G Bondy, J Bradley, P Bragaglia, S Brault, M Brittain, R Brossoit, S Brown, S Capes, P Carmichael, D Caron, L Caruana, J Cha, P Champion, S Chan, I Chausse, R Cheung, M Chilvers, S Chisholm, M Clearwaters, C Colborne, J Conway, T Czolpinski, S Dallaire, M David, A Davis, D DeAngelis, I Delpech, R Denton, A Dufour, P Dunn, H Duong, D Eddy, S Erickson-Nesmith, D Fay, G Fox J Frohlich, M Fyfe, S Galandzy, S Gauthier, J Gillett, G Girard, G Gosselin, M Gourgues, S Gray, D Grunbaum, M Gupta, J Halle, A Hanley, P Hardin, S Harris, N Harvey, G Hoag, M Hogard, R Houlden, D Hughes, D Hunt, L Janzen, O Jenkins, J Krider, S Kwan, C Lai, A Lam, L Lambing, D Lau, C Lavallee, P Lavallee, G LeDrew, H Lee, C Legare, W Leong, D Lesperance, H Lochnan, S Ludwig, D MacNair, S Mann, M Marin, J MacFadyen, S MacLean, J Marucci, C Masson, P Maurice, S Mawani, A McCarthy, G McCarthy, D McInnis, S McLean, A McLean, D Monier, S Montreuil, L Neal, S Newman, D O'Keefe, T Oprici, J Otis, G Ouellet, M Parmar, M Paul, R Petrella, S Petrella, R Phillips, D Poisson, S Prieur, R Rabasa-Lhoret, G Rajakumar, A Rajakumar, J Raymond, D Richard, G Rideout, C Robert, Y Robitaille, D Ross, S Ross, R Rowe, C Salmon, D Saunier, C Savard, D Savard, R Sayeed, Z Sayeed, F Sestier, J Shaban, D Shu, R Sigal, J Silverberg, E Smith, R Smith, J Soucy, R Starra, B Stearn, D Steel, D Steinson, B Sternberg, D Stewart, F Stone, B Sussex, D Tippe, A Toupin-Halle, D Trapsa, S Tremblay, N Troung, J van Buuren, L VanSickle, R Verdonk, P Whitsitt, R Wilson, L Winkler, W Wong, V Woo, P Wozniak, J Yale, D Zaniol, L Zaychkowsky, G Zimakas, T Zmijowskyj, M Atkinson Altamirano, F Bello Murua, O Landaeta, G Larenas, V Raddatz Kiefer, L Roddriguez |
| سنة النشر: |
2006 |
| مصطلحات موضوعية: |
Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, General & Internal Medicine, LIFE-STYLE INTERVENTION, PHARMACOLOGICAL-TREATMENT, INSULIN-RESISTANCE, HEART-FAILURE, PREVENTION, MELLITUS, THIAZOLIDINEDIONES, PRESERVATION, METFORMIN, OUTCOMES, Adult, Blood Glucose, Diabetes Mellitus, Type 2, Fasting, Female, Follow-Up Studies, Glucose Tolerance Test, Humans, Hypoglycemic Agents, Male, Middle Aged, Patient Compliance, Rosiglitazone, DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators |
| الوصف: |
BACKGROUND: Rosiglitazone is a thiazolidinedione that reduces insulin resistance and might preserve insulin secretion. The aim of this study was to assess prospectively the drug's ability to prevent type 2 diabetes in individuals at high risk of developing the condition. METHODS: 5269 adults aged 30 years or more with impaired fasting glucose or impaired glucose tolerance, or both, and no previous cardiovascular disease were recruited from 191 sites in 21 countries and randomly assigned to receive rosiglitazone (8 mg daily; n=2365) or placebo (2634) and followed for a median of 3 years. The primary outcome was a composite of incident diabetes or death. Analyses were done by intention to treat. This trial is registered at ClinicalTrials.gov, number NCT00095654. FINDINGS: At the end of study, 59 individuals had dropped out from the rosiglitazone group and 46 from the placebo group. 306 (11.6%) individuals given rosiglitazone and 686 (26.0%) given placebo developed the composite primary outcome (hazard ratio 0.40, 95% CI 0.35-0.46; p<0.0001); 1330 (50.5%) individuals in the rosiglitazone group and 798 (30.3%) in the placebo group became normoglycaemic (1.71, 1.57-1.87; p<0.0001). Cardiovascular event rates were much the same in both groups, although 14 (0.5%) participants in the rosiglitazone group and two (0.1%) in the placebo group developed heart failure (p=0.01). INTERPRETATION: Rosiglitazone at 8 mg daily for 3 years substantially reduces incident type 2 diabetes and increases the likelihood of regression to normoglycaemia in adults with impaired fasting glucose or impaired glucose tolerance, or both. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
http://hdl.handle.net/10779/DRO/DU:22105430.v1Test; https://figshare.com/articles/journal_contribution/Effect_of_rosiglitazone_on_the_frequency_of_diabetes_in_patients_with_impaired_glucose_tolerance_or_impaired_fasting_glucose_a_randomised_controlled_trial/22105430Test |
| الإتاحة: |
http://hdl.handle.net/10779/DRO/DU:22105430.v1Test
https://figshare.com/articles/journal_contribution/Effect_of_rosiglitazone_on_the_frequency_of_diabetes_in_patients_with_impaired_glucose_tolerance_or_impaired_fasting_glucose_a_randomised_controlled_trial/22105430Test |
| حقوق: |
All Rights Reserved |
| رقم الانضمام: |
edsbas.C8CBFDD0 |
| قاعدة البيانات: |
BASE |
