Clinical observation over 991 patients with myocardial infarction and blood tests for the activity of serum enzymes LDH, AST, ALT and acid hydrolases showed that the size of the necrosis of the heart muscle and the rate of the development of autolytic processes play an important role in the development of the main complications of the disease. Some syndromes reflecting the most important pathogenic mechanisms of the development of the complications were revealed, which is of definite importance for rational treatment and prognosis of the outcomes of myocardial infarction.