دورية أكاديمية
PanDrugs2: prioritizing cancer therapies using integrated individual multi-omics data
| العنوان: | PanDrugs2: prioritizing cancer therapies using integrated individual multi-omics data |
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| المؤلفون: | Jiménez Santos, María José, Nogueira Rodríguez, Alba, Piñeiro Yáñez, Elena, López Fernández, Hugo, García Martín, Santiago, Gómez Plana, Paula, Reboiro Jato, Miguel, Gómez López, Gonzalo, González Peña, Daniel, Al-Shahrour, Fátima |
| بيانات النشر: | Nucleic Acids Research Informática Sistemas Informáticos de Nova Xeración |
| سنة النشر: | 2023 |
| المجموعة: | University of Vigo: Investigo (Repositorio Institucional de la Universidade de Vigo) |
| مصطلحات موضوعية: | 1203.04 Inteligencia Artificial, 1203.20 Sistemas de Control Medico, 3207.03 Carcinogénesis |
| الوصف: | Genomics studies routinely confront researchers with long lists of tumor alterations detected in patients. Such lists are difficult to interpret since only a minority of the alterations are relevant biomarkers for diagnosis and for designing therapeutic strategies. PanDrugs is a methodology that facilitates the interpretation of tumor molecular alterations and guides the selection of personalized treatments. To do so, PanDrugs scores gene actionability and drug feasibility to provide a prioritized evidence-based list of drugs. Here, we introduce PanDrugs2, a major upgrade of PanDrugs that, in addition to somatic variant analysis, supports a new integrated multi-omics analysis which simultaneously combines somatic and germline variants, copy number variation and gene expression data. Moreover, PanDrugs2 now considers cancer genetic dependencies to extend tumor vulnerabilities providing therapeutic options for untargetable genes. Importantly, a novel intuitive report to support clinical decision-making is generated. PanDrugs database has been updated, integrating 23 primary sources that support >74K drug–gene associations obtained from 4642 genes and 14 659 unique compounds. The database has also been reimplemented to allow semi-automatic updates to facilitate maintenance and release of future versions. PanDrugs2 does not require login and is freely available at https://www.pandrugs.orgTest/. ; Instituto de Salud Carlos III | Ref. IMP/00019 ; Agencia Estatal de Investigacion | Ref. PID2021-124188NB-I00 ; Xunta de Galicia | Ref. | Ref. ED431C2018/55 ; Xunta de Galicia | Ref. | Ref. ED431C2022/03 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 03051048 13624962 |
| العلاقة: | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2021-124188NB-I00/ES/; Nucleic Acids Research, 51(W1): W411-W418 (2023); http://hdl.handle.net/11093/5558Test; https://doi.org/10.1093/nar/gkad412Test |
| DOI: | 10.1093/nar/gkad412 |
| الإتاحة: | https://doi.org/10.1093/nar/gkad412Test http://hdl.handle.net/11093/5558Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/deed.enTest ; openAccess |
| رقم الانضمام: | edsbas.1EE8B348 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 03051048 13624962 |
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| DOI: | 10.1093/nar/gkad412 |