دورية أكاديمية
Relationship of Plasminogen Activator Inhibitor 1 4G/5G Gene Polymorphism and Nontraumatic Lunatum Avascular Necrosis
| العنوان: | Relationship of Plasminogen Activator Inhibitor 1 4G/5G Gene Polymorphism and Nontraumatic Lunatum Avascular Necrosis |
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| المؤلفون: | Gönen, M., Gönen, G.A., Tepeli, E., Demirkan, Ahmet Fahir, Aydemir, Ahmet Nadir, YörükoÄŸlu, Ali ÇaÄŸdaÅŸ |
| بيانات النشر: | W.B. Saunders |
| سنة النشر: | 2020 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | gene polymorphism, Avascular necrosis, Kienböck disease, lunate, PAI-1, genomic DNA, plasminogen activator inhibitor 1, adult, aged, allele, Article, blood sampling, clinical article, controlled study, DNA extraction, DNA polymorphism, female, gene sequence, genetic risk, genotype, homozygote, human, Kienboeck disease, lunate bone, male, PAI 1 gene, polymerase chain reaction, priority journal |
| الوصف: | Purpose: Plasminogen activator inhibitor 1 (PAI-1) is a critical enzyme that regulates coagulation and fibrinolytic systems. The aim of this study was to determine the role of PAI-1 4G/5G polymorphism in nontraumatic avascular necrosis of the lunate. Methods: The study included 45 patients with Kienböck disease and 45 healthy individuals as a control group. In both groups, genomic DNA was extracted from peripheral blood samples to determine the distributions of PAI-1 4G/5G polymorphism using allele-specific polymerase chain reaction and sequencing. Results: No statistically significant difference was determined in the distribution of the gene polymorphism between the patient and control groups. We found the 5G/5G genotype to be 1.7 times higher in the control group compared with the patient group. A 1.6-fold increase in the 4G homozygote genotype was identified in the patient group. The patient and control groups were also evaluated for 4G/4G plus 4G/5G and 5G/5G in terms of genotype distribution. No statistically significant difference was found. Conclusions: The findings suggest that the PAI-1 4G/4G polymorphism is not a genetic risk for Kienböck disease. Clinical relevance: This study aimed to reveal the genetic etiology of Kienböck disease. © 2020 American Society for Surgery of the Hand |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0363-5023 |
| العلاقة: | Journal of Hand Surgery; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/37177Test; https://doi.org/10.1016/j.jhsa.2019.09.012Test; 45; 450.e1; 450.e4; 2-s2.0-85076204077; WOS:000564653400012 |
| DOI: | 10.1016/j.jhsa.2019.09.012 |
| الإتاحة: | https://doi.org/10.1016/j.jhsa.2019.09.012Test https://hdl.handle.net/11499/37177Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.DC9A6B1A |
| قاعدة البيانات: | BASE |
| تدمد: | 03635023 |
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| DOI: | 10.1016/j.jhsa.2019.09.012 |