دورية أكاديمية
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
| العنوان: | Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations |
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| المؤلفون: | Liu, Jimmy Z, van Sommeren, Suzanne, Huang, Hailiang, Ng, Siew C, Alberts, Rudi, Takahashi, Atsushi, Ripke, Stephan, Lee, James C, Jostins, Luke, Shah, Tejas, Abedian, Shifteh, Cheon, Jae Hee, Cho, Judy, Daryani, Naser E, Franke, Lude, Fuyuno, Yuta, Hart, Ailsa, Juyal, Ramesh C, Juyal, Garima, Kim, Won Ho, Morris, Andrew P, Poustchi, Hossein, Newman, William G, Midha, Vandana, Orchard, Timothy R, Vahedi, Homayon, Sood, Ajit, Sung, Joseph J. Y, Malekzadeh, Reza, Westra, Harm Jan, Yamazaki, Keiko, Yang, Suk Kyun, Barrett, Jeffrey C, Franke, Andre, Alizadeh, Behrooz Z, Parkes, Miles, B. K, Thelma, Daly, Mark J, Kubo, Michiaki, Anderson, Carl A, Weersma, Rinse K, Abedian S, Abraham C, Achkar JP, Ahmad T, Alberts R, Alizadeh B, Amininejad L, Anathakrishnan AN, Andersen V, Anderson CA, Andrews JM, Annese V, Aumais G, Baidoo L, Baldassano RN, Balschun T, Bampton PA, Barclay M, Barrett JC, Bayless TM, Bethge J, Bewshea C, Bis JC, Bitton A, B. K. T, Boucher G, Brain O, Brand S, Brant SR, Büning C, Cheon JH, Chew A, Cho JH, Cleynen I, Cohain A, Cooney R, Croft A, Daly MJ, D'Amato M, Danese S, Daryani NE, De Jong D, de Lange KM, De Vos M, Denapiene G, Denson LA, Devaney KL, Dewit O, D'Inca R, Drummond HE, Dubinsky M, Duerr RH, Edwards C, Ellinghaus D, Esaki M, Essers J, Ferguson LR, Festen EA, Fleshner P, Florin T, Franchimont D, Franke A, Fransen K, Fuyano Y, Gearry R, Georges M, Gieger C, Glas J, Goyette P, Green T, Griffiths AM, Guthery SL, Hakonarson H, Halfvarson J, Hanigan K, Haritunians T, Hart A, Hawkey C, Hayward NK, Hedl M, Henderson P, Hold GL, Hu X, Huang H, Hui KY, Imielinski M, Ippoliti A, Jazayeri O, Jonaitis L, Jostins L, Juyal G, Juyal RC, Kalla R, Karlsen TH, Kawaguchi T, Kennedy NA, Khan MA, Kim WH, Kitazono T, Kiudelis G, Kubo M, Kugathasan S, Kupcinskas L, Lamb CA, Latiano A, Laukens D, Lawrance IC, Lee JC, Lees CW, Leja M, Lewis N, Van Limbergen J, Lionetti P, Liu JZ, Louis E, Luo Y, Mahy G, Malekzadeh MM, Malekzadeh R, Mansfield J, Marriott S, Massey D, Mathew CG, Matsui T, McGovern DP, Midha V, Milgrom R, Mirzaei S, Mitrovic M, Montgomery GW, Motoya S, Mowat C, Newman WG, Ng A, Ng SC, Ng SM, Nikolaus S, Nimmo ER, Ning K, Nöthen M, Oikonomou I, Orchard TR, Palmieri O, Parkes M, Phillips A, Ponsioen CY, Potocnik U, Poustchi H, Prescott NJ, Proctor DD, Radford Smith G, Rahier JF, Raychaudhuri S, Regueiro M, Rieder F, Rioux JD, Ripke S, Roberts R, Russell RK, Sanderson JD, Sans M, Satsangi J, Schadt EE, Schreiber S, Schumm LP, Scott R, Seielstad M, Shah T, Sharma Y, Silverberg MS, Simmons A, Simms LA, Singh A, Skieceviciene J, Sood A, Spain SL, Steinhart AH, Stempak JM, STRONATI, LAURA, Sung JJ, Suzuki Y, Sventoraityte J, Takahashi A, Takazoe M, Tanaka H, Taylor KM, ter Velde A, Theatre E, Torkvist L, Tremelling M, Uhlig HH, Vahedi H, van der Meulen A, van Sommeren S, Vasiliauskas E, Ventham NT, Vermeire S, Verspaget HW, Walters T, Wang K, Wang MH, Weersma RK, Wei Z, Whiteman D, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Yamada T, Yamazaki K, Zeissig S, Zhang B, Zhang CK, Zhang H, Zhang W, Zhao H, Zhao ZZ |
| المساهمون: | Liu, Jimmy Z, van Sommeren, Suzanne, Huang, Hailiang, Ng, Siew C, Alberts, Rudi, Takahashi, Atsushi, Ripke, Stephan, Lee, James C, Jostins, Luke, Shah, Teja, Abedian, Shifteh, Cheon, Jae Hee, Cho, Judy, Daryani, Naser E, Franke, Lude, Fuyuno, Yuta, Hart, Ailsa, Juyal, Ramesh C, Juyal, Garima, Kim, Won Ho, Morris, Andrew P, Poustchi, Hossein, Newman, William G, Midha, Vandana, Orchard, Timothy R, Vahedi, Homayon, Sood, Ajit, Sung, Joseph J. Y, Malekzadeh, Reza, Westra, Harm Jan, Yamazaki, Keiko, Yang, Suk Kyun, Barrett, Jeffrey C, Franke, Andre, Alizadeh, Behrooz Z, Parkes, Mile, B. K, Thelma, Daly, Mark J, Kubo, Michiaki, Anderson, Carl A, Weersma, Rinse K, Abedian, S, Abraham, C, Achkar, Jp, Ahmad, T, Alberts, R, Alizadeh, B, Amininejad, L, Anathakrishnan, An, Andersen, V, Anderson, Ca, Andrews, Jm, Annese, V, Aumais, G, Baidoo, L, Baldassano, Rn, Balschun, T, Bampton, Pa, Barclay, M, Barrett, Jc, Bayless, Tm, Bethge, J, Bewshea, C, Bis, Jc, Bitton, A, B. K., T, Boucher, G, Brain, O, Brand, S, Brant, Sr, Büning, C, Cheon, Jh, Chew, A, Cho, Jh, Cleynen, I, Cohain, A, Cooney, R, Croft, A, Daly, Mj, D'Amato, M, Danese, S, Daryani, Ne, De Jong, D, de Lange, Km, De Vos, M, Denapiene, G, Denson, La, Devaney, Kl, Dewit, O, D'Inca, R, Drummond, He, Dubinsky, M, Duerr, Rh, Edwards, C, Ellinghaus, D, Esaki, M, Essers, J, Ferguson, Lr, Festen, Ea, Fleshner, P |
| سنة النشر: | 2015 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | case-control studie, colitis, ulcerative, Crohn disease, gene frequency, genetic loci, genetic predisposition to disease, genome-wide association study, human, polymorphism, single nucleotide, risk factors |
| الوصف: | Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease (IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and Immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent. We implicate 38 loci in IBD risk for the first time. For the majority of the IBD risk loci, the direction and magnitude of effect are consistent in European and non-European cohorts. Nevertheless, we observe genetic heterogeneity between divergent populations at several established risk loci driven by differences in allele frequency (NOD2) or effect size (TNFSF15 and ATG16L1) or a combination of these factors (IL23R and IRGM). Our results provide biological insights into the pathogenesis of IBD and demonstrate the usefulness of trans-ancestry association studies for mapping loci associated with complex diseases and understanding genetic architecture across diverse populations. ; Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease (IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and Immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent. We implicate 38 loci in IBD risk for the first time. For the majority of the IBD risk loci, the direction and magnitude of effect are consistent in European and non-European cohorts. Nevertheless, we observe genetic heterogeneity between divergent populations at several established risk loci driven by differences in allele frequency (NOD2) or effect size (TNFSF15 and ATG16L1) or a combination of these factors (IL23R and IRGM). Our results provide biological insights into the pathogenesis of IBD and demonstrate the usefulness of trans-ancestry association studies for mapping loci associated with complex diseases and understanding genetic architecture ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26192919; info:eu-repo/semantics/altIdentifier/wos/WOS:000360394100007; volume:47; issue:9; firstpage:979-86; journal:NATURE GENETICS; http://hdl.handle.net/11573/871100Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84940771118 |
| DOI: | 10.1038/ng.3359 |
| الإتاحة: | https://doi.org/10.1038/ng.3359Test http://hdl.handle.net/11573/871100Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.78077720 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ng.3359 |
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