نتائج البحث - "Frydenvang, Karla"

1

دورية أكاديمية

The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2

المؤلفون: Bay, Yasmin, Egeberg Jeppesen, Mie, Frydenvang, Karla, Francotte, Pierre, Pirotte, Bernard, Pickering, Darryl S., Kristensen, Anders Skov, Kastrup, Jette Sandholm

المصدر: Bay , Y , Egeberg Jeppesen , M , Frydenvang , K , Francotte , P , Pirotte , B , Pickering , D S , Kristensen , A S & Kastrup , J S 2024 , ' The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2 ' , FEBS Letters , vol. 598 , no. 7 , pp. 743-757 . https://doi.org/10.1002/1873-3468.14824Test

مصطلحات موضوعية: BPAM344 binding mode, calcium-sensitive fluorescence-based assay, dimer interface, GluK2 mutations, positive allosteric modulation, X-ray crystallography

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1002/1873-3468.14824Test
https://curis.ku.dk/portal/da/publications/the-positive-allosteric-modulator-bpam344-and-lglutamate-introduce-an-activelike-structure-of-the-ligandbinding-domain-of-gluk2Test(edc0b943-651d-4436-ac37-82f7e06d37e7).html
https://curis.ku.dk/ws/files/387737935/FEBS_Letters_2024_Bay_The_positive_allosteric_modulator_BPAM344_and_L_glutamate_introduce_an_active_like_structure_of.pdfTest

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2

دورية أكاديمية

Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer

المصدر: Pippione , A C , Kovachka , S , Vigato , C , Bertarini , L , Mannella , I , Sainas , S , Rolando , B , Denasio , E , Piercy-Mycock , H , Romalho , L , Salladini , E , Adinolfi , S , Zonari , D , Peraldo-Neia , C , Chiorino , G , Passoni , A , Mirza , O A , Frydenvang , K , Pors , K , Lolli , M L , Spyrakis , F , Oliaro-Bosso , S & Boschi , D 2024 , ' Structure-guided optimization ....

مصطلحات موضوعية: AKR1C3 inhibitors, Benzoisoxazoles, Prostate cancer, X-ray crystallography

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1016/j.ejmech.2024.116193Test
https://curis.ku.dk/portal/da/publications/structureguided-optimization-of-3hydroxybenzoisoxazole-derivatives-as-inhibitors-of-aldoketo-reductase-1c3-akr1c3-to-target-prostate-cancerTest(04b758c2-547a-465b-a86f-7591208fe306).html
https://curis.ku.dk/ws/files/384875887/1_s2.0_S0223523424000734_main.pdfTest

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3

دورية أكاديمية

Discovery and Structure–Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT 2A Receptor Agonists

المؤلفون: M. Ro̷rsted, Emil, Jensen, Anders A., Smits, Gints, Frydenvang, Karla, Kristensen, Jesper L.

المساهمون: Novo Nordisk Fonden, Lundbeck Foundation

المصدر: Journal of Medicinal Chemistry ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.4c00082Test

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4

دورية أكاديمية

Exploring thienothiadiazine dioxides as isosteric analogues of benzo-and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators

المؤلفون: Francotte, Pierre, Bay, Yasmin, Goffin, Eric, Colson, Thomas, Lesenfants, Cindy, Dorosz, Jerzy, Laulumaa, Saara, Fraikin, Pierre, De Tullio, Pascal, Beaufour, Caroline, Botez, Iuliana, Pickering, Darryl, Frydenvang, Karla, Danober, Laurence, Skov Kristensen, Anders, Sandholm Kastrup, Jette, Pirotte, Bernard

المصدر: European Journal of Medicinal Chemistry, 264, 116036 (2023-12-09)

مصطلحات موضوعية: Ionotropic glutamate receptors Positive allosteric modulators thieno[3, 2-e]-1, 2, 4-thiadiazine 1, 1-dioxides 1, 4-Benzothiadiazine 1, 1-dioxides X-ray crystallography Calcium-sensitive fluorescence-based assay, Organic Chemistry, Drug Discovery, Pharmacology, General Medicine, Human health sciences, Pharmacy, pharmacology & toxicology, Physical, chemical, mathematical & earth Sciences, Chemistry, Sciences de la santé humaine, Pharmacie, pharmacologie & toxicologie, Physique, chimie, mathématiques & sciences de la terre, Chimie

العلاقة: https://api.elsevier.com/content/article/PII:S0223523423010036?httpAccept=text/xmlTest; urn:issn:0223-5234; urn:issn:1768-3254

الوصول الحر: https://orbi.uliege.be/handle/2268/312961Test

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5

دورية أكاديمية

Discovery and Structure–Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5‑HT2A Receptor Agonists.

المؤلفون: M. Ro̷rsted, Emil, Jensen, Anders A., Smits, Gints, Frydenvang, Karla, Kristensen, Jesper L.

المصدر: Journal of Medicinal Chemistry; 5/9/2024, Vol. 67 Issue 9, p7224-7244, 21p

6

دورية أكاديمية

AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications

المؤلفون: Pippione, Agnese C., Vigato, Chiara, Tucciarello, Cristina, Hussain, Samrina, Salladini, Edoardo, Truong, Ha H., Henriksen, Niel M., Vanzetti, Gaia, Giordano, Giorgia, Zonari, Daniele, Mirza, Osman Asghar, Frydenvang, Karla, Pignochino, Ymera, Oliaro-Bosso, Simonetta, Boschi, Donatella, Lolli, Marco L.

المساهمون: Universit?? degli Studi di Torino, Ministero della Salute, Cassa di Risparmio di Torino

المصدر: ACS Medicinal Chemistry Letters ; ISSN 1948-5875 1948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.4c00150Test

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7

دورية أكاديمية

Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3:development of screening assays and insight into GluK3 structure

المؤلفون: Bay, Yasmin, Venskutonytė, Raminta, Frantsen, Stine M., Thorsen, Thor S., Musgaard, Maria, Frydenvang, Karla, Francotte, Pierre, Pirotte, Bernard, Biggin, Philip C., Kristensen, Anders S., Boesen, Thomas, Pickering, Darryl S., Gajhede, Michael, Kastrup, Jette S.

المصدر: Bay , Y , Venskutonytė , R , Frantsen , S M , Thorsen , T S , Musgaard , M , Frydenvang , K , Francotte , P , Pirotte , B , Biggin , P C , Kristensen , A S , Boesen , T , Pickering , D S , Gajhede , M & Kastrup , J S 2024 , ' Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3 : development of screening assays and insight into GluK3 structure ' , FEBS journal , vol. 291 , no. 7 , pp. 1506-1529 . https://doi.org/10.1111/febs.17046Test

مصطلحات موضوعية: calcium-sensitive fluorescence-based assays, electron microscopy, kainate receptors, molecular dynamics simulations, X-ray crystallography

العلاقة: https://pure.au.dk/portal/en/publications/ed55e272-6246-4232-af77-692cd51146c8Test

الإتاحة: https://doi.org/10.1111/febs.17046Test
https://pure.au.dk/portal/en/publications/ed55e272-6246-4232-af77-692cd51146c8Test
http://www.scopus.com/inward/record.url?scp=85185918937&partnerID=8YFLogxKTest

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8

دورية أكاديمية

Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators

المؤلفون: Francotte, Pierre, Bay, Yasmin, Goffin, Eric, Colson, Thomas, Lesenfants, Cindy, Dorosz, Jerzy, Laulumaa, Saara, Fraikin, Pierre, de Tullio, Pascal, Beaufour, Caroline, Botez, Iuliana, Pickering, Darryl S., Frydenvang, Karla, Danober, Laurence, Kristensen, Anders Skov, Kastrup, Jette Sandholm, Pirotte, Bernard

المصدر: Francotte , P , Bay , Y , Goffin , E , Colson , T , Lesenfants , C , Dorosz , J , Laulumaa , S , Fraikin , P , de Tullio , P , Beaufour , C , Botez , I , Pickering , D S , Frydenvang , K , Danober , L , Kristensen , A S , Kastrup , J S & Pirotte , B 2024 , ' Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators ' , ....

مصطلحات موضوعية: 1,2,4-Benzothiadiazine 1,1-dioxides, Calcium-sensitive fluorescence-based assay, Ionotropic glutamate receptors, Positive allosteric modulators, thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxides, X-ray crystallography

الإتاحة: https://doi.org/10.1016/j.ejmech.2023.116036Test
https://curis.ku.dk/portal/da/publications/exploring-thienothiadiazine-dioxides-as-isosteric-analogues-of-benzo-and-pyridothiadiazine-dioxides-in-the-search-of-new-ampa-and-kainate-receptor-positive-allosteric-modulatorsTest(4ff101cd-50ac-44e4-8b8c-dfcfe8ce4852).html

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