Relative roles of endothelial cell damage and platelet activation in primary Raynaud's phenomenon (RP) and RP secondary to systemic sclerosis
| العنوان: | Relative roles of endothelial cell damage and platelet activation in primary Raynaud's phenomenon (RP) and RP secondary to systemic sclerosis |
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| المؤلفون: | Ferdinando Silveri, Andreina Poggi, Stefania Muti, Rossella De Angelis, Claudio Cervini, Giuseppe Bonapace, Franco Argentati |
| المصدر: | Scandinavian Journal of Rheumatology. 30:290-296 |
| بيانات النشر: | Informa UK Limited, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Endothelium, Immunology, Pathogenesis, chemistry.chemical_compound, Rheumatology, Transforming Growth Factor beta, Internal medicine, Plasminogen Activator Inhibitor 1, medicine, Humans, Immunology and Allergy, Platelet, Platelet activation, skin and connective tissue diseases, Platelet-Derived Growth Factor, Scleroderma, Systemic, Endothelin-1, biology, Platelet-activating factor, business.industry, Raynaud Disease, General Medicine, Middle Aged, Platelet Activation, beta-Thromboglobulin, Endothelin 1, Endothelial stem cell, Endocrinology, medicine.anatomical_structure, chemistry, Tissue Plasminogen Activator, biology.protein, Female, business, Biomarkers, Platelet-derived growth factor receptor |
| الوصف: | Objective : To evaluate the relative roles of endothelium and platelets in the pathogenesis of primary RP and RP secondary to SSc. Methods : Endothelial derived ET-1, t-PA, PAI-1, and platelet derived g -TG, PDGF, TGF- g were measured in 36 patients with primary RP, 14 patients with RP secondary to SSc and 30 age and sex matched controls. Results : A significative increase of ET-1, t-PA, PAI-1, TGF- g, and g -TG were the most relevant changes in patients with RP secondary to SSc with respect to the controls. Less relevant increases of t-PA, PAI-1, PDGF, and g -TG levels were observed in patients with primary RP vs controls. Conclusions : These data seem to confirm the involvement of endothelial cells and platelets in the pathogenesis of RP, with mild changes in primary RP and more relevant changes in RP secondary to SSc. |
| تدمد: | 1502-7732 0300-9742 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e0ed4050dd5491b9eae474b2a8b98dTest https://doi.org/10.1080/030097401753180372Test |
| رقم الانضمام: | edsair.doi.dedup.....d7e0ed4050dd5491b9eae474b2a8b98d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15027732 03009742 |
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