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1دورية أكاديمية
المؤلفون: Johannes A. Burkhard, Sebastian Herold, Christian Leitner, Haiming Zhang, Rémy Angelaud, Qingping Tian, Chong Han, Francis Gosselin
مصطلحات موضوعية: Biophysics, Biochemistry, Immunology, Developmental Biology, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unusual halogen scrambling, nine chemical steps, minimal purging power, low levels due, kras g12c inhibitor, dabco − msoh, catalyzed halex reaction, highly functionalized quinazoline, streamlined manufacturing process, 2 sub, 2 b, streamlined process, manufacturing process, key 2, divarasib <, telescoped four, presented herein, overall yield, hplc purity, fluorobenzonitrile intermediate, five isolations, enabled late, downstream chemistry
الإتاحة: https://doi.org/10.1021/acs.oprd.3c00351.s001Test
https://figshare.com/articles/journal_contribution/Development_of_a_Streamlined_Manufacturing_Process_for_the_Highly_Substituted_Quinazoline_Core_Present_in_KRAS_G12C_Inhibitor_i_Divarasib_i_/24968782Test -
2دورية أكاديمية
المؤلفون: Natalie P. Romer, Daniel S. Min, Jason Y. Wang, Richard C. Walroth, Kyle A. Mack, Lauren E. Sirois, Francis Gosselin, Daniel Zell, Abigail G. Doyle, Matthew S. Sigman
مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Biotechnology, Cancer, Computational Biology, Biological Sciences not elsewhere classified, Information Systems not elsewhere classified, training set design, thereby expanding access, untested monophosphine ligands, improved reaction parameters, stereodefined trisubstituted alkenes, corresponding enol tosylates, >- trisubstituted products, multiobjective bayesian optimization, >- isomer formation, trisubstituted alkenes, enol tosylates, reaction optimization, bayesian optimization, stereoconvergent formation, monophosphine ligand, ∼ 30, z <, two steps, stereoconvergent synthesis, statistical modeling, search space, predominantly relies
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3دورية أكاديمية
المؤلفون: Jeff Shen, Nicholas A. White, Qingping Tian, Lauren E. Sirois, Haiming Zhang, Francis Gosselin
مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, generation route furnishing, bromine halogen exchange, 5 -( trifluoromethyl, additional process research, comprised 9 steps, generation manufacturing process, methoxybenzyl )- 4, 1 b, amine (< b, manufacturing process, n <, 3 steps, superstoichiometric copper, sub ><, scalable second, readily available, mediated trifluoromethylation, key intermediate, development enabled, bromo -<
الإتاحة: https://doi.org/10.1021/acs.oprd.3c00366.s001Test
https://figshare.com/articles/journal_contribution/Manufacturing_Process_for_6_Bromo_i_N_i_i_N_i_bis_4-methoxybenzyl_-4-methyl-5-_trifluoromethyl_pyridin-2-amine_a_Key_Intermediate_in_the_Synthesis_of_KRAS_G12C_Inhibitor_Divarasib/24919538Test -
4دورية أكاديمية
المؤلفون: Fabienne Hoffmann-Emery (2648983), Katrin Niedermann (1332993), Pankaj D. Rege (2536939), Manuel Konrath (11979810), Christian Lautz (1883692), Anne Katrin Kraft (11979813), Carine Steiner (196548), Fritz Bliss (9993124), André Hell (4405729), Rolf Fischer (11979816), Diane E. Carrera (1442908), Danial Beaudry (5131568), Remy Angelaud (1442911), Sushant Malhotra (1784344), Francis Gosselin (1442914)
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, produce 150 kg, minimizing uncontrolled h, process mass intensity, n sub, 2 sub, 0134 comprising two, dosing h, greener process, generation process, two steps, suzuki coupling, sulfonyl intermediate, successfully used, strong specifications, solvents classified, reducing accumulation, reaction conditions, reach regulation, particular focus, higher temperatures, higher concentrations, high concern, faster way
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5
المؤلفون: Jie Xu, Ngiap-Kie Lim, Jacob C. Timmerman, Jeff Shen, Kyle Clagg, Ugo Orcel, Raphael Bigler, Etienne Trachsel, Roland Meier, Nicholas A. White, Johannes A. Burkhard, Lauren E. Sirois, Qingping Tian, Remy Angelaud, Stephan Bachmann, Haiming Zhang, Francis Gosselin
المصدر: Organic Letters. 25:3417-3422
مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry, Biochemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::09cbdcd4382cf571f2b56ef6bc311558Test
https://doi.org/10.1021/acs.orglett.3c00961Test -
6
المؤلفون: Andreas Stumpf, Di Xu, Rohit Ranjan, Remy Angelaud, Francis Gosselin
المصدر: Organic Process Research & Development. 27:523-529
مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fcd4b29171f5374e91b4bfc12a689973Test
https://doi.org/10.1021/acs.oprd.2c00384Test -
7دورية أكاديمية
المؤلفون: Daniel Zell (1493587), Michael E. Dalziel (4111468), Diane E. Carrera (1442908), Andreas Stumpf (1581568), Stephan Bachmann (1438546), Eduardo Mercado-Marin (11421228), Stefan G. Koenig (1798633), Haiming Zhang (651820), Francis Gosselin (1442914)
مصطلحات موضوعية: Biophysics, Developmental Biology, Marine Biology, Mental Health, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, safe protocol employing, multikilogram production scale, highly chemoselective pt, catalyzed carbonylation reaction, >′- tetramethylchloroformamidinium hexafluorophosphate, final amide coupling, efficient key reactions, streamlined manufacturing process, raf inhibitor belvarafenib, generation manufacturing process, >, n <, 2 b, efficient second, coupling reagent, belvarafenib features, afforded belvarafenib, scalable pd, penultimate intermediate, generate thienopyrimidine
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8دورية أكاديمية
المؤلفون: Daniel Zell (1493587), Cian Kingston (3862867), Janis Jermaks (1438639), Sleight R. Smith (11648195), Natalie Seeger (2606950), Jana Wassmer (11648198), Lauren E. Sirois (2068171), Chong Han (818950), Haiming Zhang (651820), Matthew S. Sigman (1306671), Francis Gosselin (1442914)
مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Biotechnology, Immunology, Chemical Sciences not elsewhere classified, results provided insight, optimized catalytic system, boronic acid esters, b >- b, detailed computational analysis, chemical space analysis, various tetrasubstituted alkenes, either diastereomeric product, tetrasubstituted alkenes, stereoelectronic analysis, product isomer, diastereomeric ratios, z <, throughput optimization, synthetic utility, stereoselective synthesis, selectively accessed, reaction conditions, kraken <, judicious choice, enol tosylates, e <, diverse selection, divergent synthesis
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9دورية أكاديمية
المؤلفون: Jie Xu (34477), Cheol K. Chung (1857052), Andrew McClory (2531356), Kyle A. Mack (3595676), Michael E. Dalziel (4111468), Alec Fettes (1883689), Kyle Clagg (1695886), Ngiap-Kie Lim (1667338), Georg Wuitschik (532037), Christian Jenny (11668140), Laure Finet (11668143), Michael Kammerer (11668146), Haiming Zhang (651820), Rémy Angelaud (2226466), Francis Gosselin (1442914)
مصطلحات موضوعية: Biochemistry, Molecular Biology, Evolutionary Biology, Developmental Biology, Cancer, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, wenker aziridine synthesis, construct key intermediate, efficient manufacturing process, convergent manufacturing process, 9545 · tartrate, 9 b, process features
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10دورية أكاديمية
المؤلفون: Andreas Stumpf (1581568), Johannes Burkhard (2423572), Di Xu (1443394), Andreas Marx (559902), David Lao (2437354), Miriam Ochsenbein (11681338), Rohit Ranjan (11681341), Remy Angelaud (1442911), Francis Gosselin (1442914)
مصطلحات موضوعية: Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, size distribution suitable, endgame process features, jak1 inhibitor gdc, 4379 b, 4 sub, jak1 inhibitor, new process, wet milling, transfer conditions, telescoped oximation, selective n, scale synthesis, pyrazole moiety, provide access, penultimate intermediate, novel copper, nitroso group, improved kilogram, hydrazine condensation, generate nitrosopyrazole, economical construction, defined particle