المؤلفون: Dario Zimmerli, Chiara S. Brambillasca, Francien Talens, Jinhyuk Bhin, Renske Linstra, Lou Romanens, Arkajyoti Bhattacharya, Stacey E. P. Joosten, Ana Moises Da Silva, Nuno Padrao, Max D. Wellenstein, Kelly Kersten, Mart de Boo, Maurits Roorda, Linda Henneman, Roebi de Bruijn, Stefano Annunziato, Eline van der Burg, Anne Paulien Drenth, Catrin Lutz, Theresa Endres, Marieke van de Ven, Martin Eilers, Lodewyk Wessels, Karin E. de Visser, Wilbert Zwart, Rudolf S. N. Fehrmann, Marcel A. T. M. van Vugt, Jos Jonkers

المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/07f7321be51a4bf993332239abb08b2bTest

المؤلفون: Anne Margriet Heijink, Francien Talens, Lucas T. Jae, Stephanie E. van Gijn, Rudolf S. N. Fehrmann, Thijn R. Brummelkamp, Marcel A. T. M. van Vugt

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/fe87c5673305416fa0c30e5631b208edTest

المؤلفون: Pepijn M. Schoonen, Francien Talens, Colin Stok, Ewa Gogola, Anne Margriet Heijink, Peter Bouwman, Floris Foijer, Madalena Tarsounas, Sohvi Blatter, Jos Jonkers, Sven Rottenberg, Marcel A. T. M. van Vugt

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/86272fb47c1c44e091878a6dfa6f26deTest

المؤلفون: Ana Moises Da Silva, Stacey E. P. Joosten, Jinhyuk Bhin, Marcel A. T. M. van Vugt, Maurits Roorda, Wilbert Zwart, Anne Paulien Drenth, Chiara S. Brambillasca, Roebi de Bruijn, Lodewyk F. A. Wessels, Rudolf S N Fehrmann, Catrin Lutz, Linda Henneman, Arkajyoti Bhattacharya, Dario Zimmerli, Eline van der Burg, Jos Jonkers, Max D. Wellenstein, Marieke van de Ven, Karin E. de Visser, Francien Talens, Stefano Annunziato, Mart de Boo, Kelly Kersten

مصطلحات موضوعية: Innate immune system, Immune system, Transcription (biology), Interferon, Stimulator of interferon genes, Immunogenicity, Cancer research, medicine, Promoter, Biology, Chromatin immunoprecipitation, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f1a3a50f12778f74686f5c57e2768675Test
https://doi.org/10.1101/2021.02.24.432659Test

المؤلفون: Marcel A. T. M. van Vugt, Thijn R. Brummelkamp, Anne Margriet Heijink, Stephanie E van Gijn, Rudolf S N Fehrmann, Francien Talens, Lucas T. Jae

المساهمون: Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), University of Zurich, van Vugt, Marcel A T M

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, 10(1):100. Nature Publishing Group

مصطلحات موضوعية: 0301 basic medicine, endocrine system diseases, 10039 Institute of Medical Genetics, medicine.medical_treatment, NF-KAPPA-B, CANCER SUSCEPTIBILITY GENE, General Physics and Astronomy, 02 engineering and technology, CHROMOSOMAL INSTABILITY, HOMOLOGOUS RECOMBINATION, Interferon, ASK1, skin and connective tissue diseases, lcsh:Science, Multidisciplinary, Chemistry, 021001 nanoscience & nanotechnology, Nucleotidyltransferases, 3100 General Physics and Astronomy, female genital diseases and pregnancy complications, 3. Good health, Cytokine, STRAND BREAK REPAIR, Tumor necrosis factor alpha, Signal transduction, 0210 nano-technology, Signal Transduction, medicine.drug, Programmed cell death, Cell Survival, Science, 610 Medicine & health, 1600 General Chemistry, DNA-DAMAGE RESPONSE, EMBRYONIC CELLULAR PROLIFERATION, SUSTAINED JNK ACTIVATION, MICE LACKING, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, 1300 General Biochemistry, Genetics and Molecular Biology, medicine, Humans, neoplasms, BRCA2 Protein, Inflammation, Tumor Necrosis Factor-alpha, HUMAN-CELLS, General Chemistry, NFKB1, 030104 developmental biology, Cell culture, Cancer research, 570 Life sciences, biology, lcsh:Q, Gene Deletion

وصف الملف: application/pdf; s41467-018-07927-y.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593ab79c1e19556680c972035bd9fc32Test
http://link.springer.com/article/10.1038/s41467-018-07927-yTest

المؤلفون: Francien Talens

المساهمون: van Vugt, Marcel, Gietema, Jourik

مصطلحات موضوعية: Computational biology, Biology, skin and connective tissue diseases, Homologous recombination, Selection (genetic algorithm)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb6e432abe6b2b792218b0bab36aa22Test
https://research.rug.nl/en/publications/b00e2986-e8e8-43f1-bd2c-6a913a020671Test

المؤلفون: Francien Talens, Colin Stok, Sven Rottenberg, Ewa Gogola, Floris Foijer, Madalena Tarsounas, Marcel A. T. M. van Vugt, Peter Bouwman, Pepijn M Schoonen, Sohvi Blatter, Anne Margriet Heijink, Jos Jonkers

المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)

المصدر: Nature Communications
Schoonen, Pepijn M; Talens, Francien; Stok, Colin; Gogola, Ewa; Heijink, Anne Margriet; Bouwman, Peter; Foijer, Floris; Tarsounas, Madalena; Blatter, Sohvi Tuulikki; Jonkers, Jos; Rottenberg, Sven; van Vugt, Marcel A T M (2017). Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells. Nature communications, 8(15981), p. 15981. Nature Publishing Group 10.1038/ncomms15981 <http://dx.doi.org/10.1038/ncomms15981Test>
Nature Communications, 8:15981. Nature Publishing Group
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

مصطلحات موضوعية: 0301 basic medicine, General Physics and Astronomy, POLY(ADP-RIBOSE) POLYMERASE, medicine.disease_cause, Poly (ADP-Ribose) Polymerase Inhibitor, FRAGILE SITES, Mice, skin and connective tissue diseases, Mice, Knockout, Multidisciplinary, 630 Agriculture, BRCA1 Protein, 3. Good health, Chromatin, SUSCEPTIBILITY GENE, STRAND BREAK REPAIR, PARP inhibitor, Female, Science, Poly ADP ribose polymerase, MAMMARY-TUMORS, Mitosis, Breast Neoplasms, Mammary Neoplasms, Animal, 610 Medicine & health, Poly(ADP-ribose) Polymerase Inhibitors, Biology, Article, General Biochemistry, Genetics and Molecular Biology, SYNTHETIC LETHALITY, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, Cytokinesis, BRCA2 Protein, Tumor Suppressor Proteins, ADP-RIBOSE POLYMERASE, Mammary Neoplasms, Experimental, Recombinational DNA Repair, General Chemistry, BRCA2-DEFICIENT TUMORS, 030104 developmental biology, Cancer cell, FANCONI-ANEMIA, REPLICATION, Cancer research, 570 Life sciences, biology, Tumor Suppressor Protein p53, Anaphase, Carcinogenesis, DNA Damage, HeLa Cells

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70117100ba952781234384abba7c4cbaTest
https://hdl.handle.net/11370/191d6e7a-6e93-40f6-92c5-9e17409a85caTest

المؤلفون: Mathilde Jalving, Marcel A. T. M. van Vugt, Francien Talens, Jourik A. Gietema

المصدر: Expert Opinion on Drug Discovery

مصطلحات موضوعية: 0301 basic medicine, Genome instability, homologous recombination, Synthetic lethality, DOUBLE-STRAND BREAKS, chemistry.chemical_compound, 0302 clinical medicine, BRCA2 MUTATION CARRIERS, Drug Discovery, DNA Breaks, Double-Stranded, Molecular Targeted Therapy, DNA END RESECTION, Ovarian Neoplasms, BRCA1 Protein, personalized medicine, 3. Good health, 030220 oncology & carcinogenesis, SENSITIVE OVARIAN-CANCER, PARP inhibitor, Lynparza, Female, Context (language use), Breast Neoplasms, EMBRYONIC CELLULAR PROLIFERATION, Biology, Poly(ADP-ribose) Polymerase Inhibitors, olaparib, Olaparib, 03 medical and health sciences, medicine, Animals, Humans, Genetic Predisposition to Disease, EX-VIVO ASSAY, BRCA2 Protein, FANCONI-ANEMIA PATHWAY, Patient Selection, Cancer, Recombinational DNA Repair, RANDOMIZED PHASE-2 TRIAL, BRCA1, medicine.disease, BRCA2, genome instability, synthetic lethality, NEGATIVE BREAST-CANCER, 030104 developmental biology, chemistry, OLAPARIB MAINTENANCE THERAPY, Drug Design, Mutation, Cancer research, Ovarian cancer, Homologous recombination

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c0403601531c5f53f764f17dff1b04Test

المؤلفون: Francien Talens, Anouk Baars, Anne Margriet Heijink, Marcel A. T. M. van Vugt

المصدر: Cancer Research. 77:2488-2488

مصطلحات موضوعية: Cancer Research, Oncology, Cell culture, DNA repair, Cancer cell, Cancer research, Tumor necrosis factor alpha, Viability assay, Biology, Gene mutation, Clonogenic assay, Autocrine signalling

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3afe8fee505cf0a6e643bba81319ef78Test
https://doi.org/10.1158/1538-7445.am2017-2488Test

المؤلفون: Francien Talens, Marcel A. T. M. van Vugt

المصدر: Cell Cycle

مصطلحات موضوعية: 0301 basic medicine, Genome instability, DNA Repair, Review, CHROMOSOMAL INSTABILITY, 0302 clinical medicine, Cytosol, AICARDI-GOUTIERES-SYNDROME, Chromosome instability, Neoplasms, Tumor Microenvironment, Molecular Targeted Therapy, I INTERFERON, TUMOR-REGRESSION, cytoplasmic DNA, INTRACELLULAR DNA, Nucleotidyltransferases, 3. Good health, 030220 oncology & carcinogenesis, interferon response, CYTOSOLIC DNA SENSOR, Immunotherapy, INNATE IMMUNE SENSOR, Signal Transduction, Genomic instability, DNA, Single-Stranded, Tumor cells, Biology, 03 medical and health sciences, Breast cancer, medicine, BREAST-CANCER, Animals, Humans, inflammatory signaling, Molecular Biology, Inflammation, Tumor microenvironment, Membrane Proteins, CYCLIC GMP-AMP, Cell Biology, medicine.disease, Immune surveillance, eye diseases, Sting, 030104 developmental biology, Cancer research, Aicardi–Goutières syndrome, Tumor Escape, DEPENDENT ANTITUMOR IMMUNITY, Developmental Biology, DNA Damage, cGAS, STING

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80b5c416b24a1402beb113b1e71b115Test