دورية أكاديمية
Cognitive and affective changes in mild to moderate Alzheimer's disease patients undergoing switch of cholinesterase inhibitors: a 6-month observational study.
| العنوان: | Cognitive and affective changes in mild to moderate Alzheimer's disease patients undergoing switch of cholinesterase inhibitors: a 6-month observational study. |
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| المؤلفون: | Spalletta G, Caltagirone C, Padovani A, Sorbi S, Attar M, Colombo D, Cravello L, Giuseppe Zappala`, Francesco Iemolo, Nicola Sermoni, Amleto Gabriele, Stefano Viola, Angiola Maria Fasanaro, Giuseppe Sancesario, Giovanni Cantone, Simonetta Mearelli, Giuseppe Acierno, Maria Cozzolino, Serenella Grioli, Emanuele Cassetta, Simone Vidale, Gabriella Bottini, Luigi Di Cioccio, Riccardo Riva, Tiziana Tassinari, Maria Grazia Arena, Alessio Pietrella, Giancarlo Logroscino, Giuseppe Gambina, Graziella Rossi, Leonardo Scarsella, Andrea Fabbo, Marco Bartolini, Camilla Prete, Michele Zito, Annachiara Cagnin, Francesco Scoppa, Stefano De Carolis, Elio Agostani, Albert March, Antonella Angelini, RAINERO, Innocenzo |
| المساهمون: | Spalletta G, Caltagirone C, Padovani A, Sorbi S, Attar M, Colombo D, Cravello L, Giuseppe Zappala`, Francesco Iemolo, Nicola Sermoni, Amleto Gabriele, Stefano Viola, Angiola Maria Fasanaro, Giuseppe Sancesario, Giovanni Cantone, Simonetta Mearelli, Innocenzo Rainero, Giuseppe Acierno, Maria Cozzolino, Serenella Grioli, Emanuele Cassetta, Simone Vidale, Gabriella Bottini, Luigi Di Cioccio, Riccardo Riva, Tiziana Tassinari, Maria Grazia Arena, Alessio Pietrella, Giancarlo Logroscino, Giuseppe Gambina, Graziella Rossi, Leonardo Scarsella, Andrea Fabbo, Marco Bartolini, Camilla Prete, Michele Zito, Annachiara Cagnin, Francesco Scoppa, Stefano De Caroli, Elio Agostani, Albert March, Antonella Angelini |
| سنة النشر: | 2014 |
| المجموعة: | Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| الوصف: | Patients with Alzheimer's disease after an initial response to cholinesterase inhibitors may complain a later lack of efficacy. This, in association with incident neuropsychiatric symptoms, may worsen patient quality of life. Thus, the switch to another cholinesterase inhibitor could represent a valid therapeutic strategy. The aim of this study was to investigate the effectiveness of the switch from one to another cholinesterase inhibitor on cognitive and affective symptoms in mild to moderate Alzheimer disease patients. Four hundred twenty-three subjects were included from the EVOLUTION study, an observational, longitudinal, multicentre study conducted on Alzheimer disease patients who switched to different cholinesterase inhibitor due either to lack/loss of efficacy or response, reduced tolerability or poor compliance. All patients underwent cognitive and neuropsychiatric assessments, carried out before the switch (baseline), and at 3 and 6-month follow-up. A significant effect of the different switch types was found on Mini-Mental State Examination score during time, with best effectiveness on mild Alzheimer's disease patients switching from oral cholinesterase inhibitors to rivastigmine patch. Depressive symptoms, when measured using continuous Neuropsychiatric Inventory values, decreased significantly, while apathy symptoms remained stable over the 6 months after the switch. However, frequency of both depression and apathy, when measured categorically using Neuropsychiatric Inventory cut-off scores, did not change significantly during time. In mild to moderate Alzheimer disease patients with loss of efficacy and tolerability during cholinesterase inhibitor treatment, the switch to another cholinesterase inhibitor may represent an important option for slowing cognitive deterioration. The evidence of apathy stabilization and the positive tendency of depressive symptom improvement should definitively be confirmed in double-blind controlled studies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/24586603; info:eu-repo/semantics/altIdentifier/wos/WOS:000331711900109; volume:9; issue:2; firstpage:89216; lastpage:89224; numberofpages:9; journal:PLOS ONE; http://hdl.handle.net/2318/145685Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84896757411 |
| DOI: | 10.1371/journal.pone.0089216 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0089216Test http://hdl.handle.net/2318/145685Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DF2C5009 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0089216 |
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