المؤلفون: Leurs, Ulrike, Klein, Anders B, McSpadden, Ethan D, Griem-Krey, Nane, Solbak, Sara MØ, Houlton, Josh, Villumsen, Inge S, Vogensen, Stine B, Hamborg, Louise, Gauger, Stine J, Palmelund, Line B, Larsen, Anne Sofie G, Shehata, Mohamed A, Kelstrup, Christian D, Olsen, Jesper V, Bach, Anders, Burnie, Robert O, Kerr, D Steven, Gowing, Emma K, Teurlings, Selina MW, C., Chris, Gee, Christine L, Frølund, Bente, Kornum, Birgitte R, van Woerden, Geeske M, Clausen, Rasmus P, Kuriyan, John, Clarkson, Andrew N, Wellendorph, Petrine

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 118(31)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Brain Disorders, Neurosciences, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Binding Sites, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Carboxylic Acids, Crystallography, X-Ray, Cyclopentanes, Gene Expression Regulation, Enzymologic, HEK293 Cells, Humans, Neuroprotection, Protein Binding, Protein Domains, Signal Transduction, Sodium Oxybate, photoaffinity labeling, x-ray crystallography, HOCPCA, excitotoxicity, photothrombotic storke, photothrombotic stroke

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6fq63908Test
https://escholarship.org/content/qt6fq63908/qt6fq63908.pdfTest

المؤلفون: Mortensen, Martin, Xu, Yue, Shehata, Mohamed A, Krall, Jacob, Ernst, Margot, Frølund, Bente, Smart, Trevor G

المصدر: British Journal of Pharmacology (2023) (In press).

مصطلحات موضوعية: GABA, GABAA receptor, chemical analogues, electrophysiology, human embryonic kidney cells, kinetic modelling, molecular dynamics simulations, organic chemistry, pregnenolone sulfate, recombinant expression, synthesis

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10171398/3/Smart_British%20J%20Pharmacology%20-%202023%20-%20Mortensen%20-%20Pregnenolone%20sulfate%20analogues%20differentially%20modulate%20GABAA%20receptor%20closed.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10171398Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10171398/3/Smart_British%20J%20Pharmacology%20-%202023%20-%20Mortensen%20-%20Pregnenolone%20sulfate%20analogues%20differentially%20modulate%20GABAA%20receptor%20closed.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10171398Test/

المؤلفون: den Hartigh, Andreas B., Loomis, Wendy P., Anderson, Marisa J., Frølund, Bente, Fink, Susan L.

المصدر: den Hartigh , A B , Loomis , W P , Anderson , M J , Frølund , B & Fink , S L 2023 , ' Muscimol inhibits plasma membrane rupture and ninjurin-1 oligomerization during pyroptosis ' , Communications Biology , vol. 6 , no. 1 , 1010 . https://doi.org/10.1038/s42003-023-05354-4Test

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1038/s42003-023-05354-4Test
https://curis.ku.dk/portal/da/publications/muscimol-inhibits-plasma-membrane-rupture-and-ninjurin1-oligomerization-during-pyroptosisTest(e78dbea1-5f9a-4ba6-8fff-121dfb00320a).html
https://curis.ku.dk/ws/files/370471925/s42003_023_05354_4.pdfTest

المؤلفون: Mortensen, Martin, Xu, Yue, Shehata, Mohamed A., Krall, Jacob, Ernst, Margot, Frølund, Bente, Smart, Trevor G.

المصدر: Mortensen , M , Xu , Y , Shehata , M A , Krall , J , Ernst , M , Frølund , B & Smart , T G 2023 , ' Pregnenolone sulfate analogues differentially modulate GABA A receptor closed/desensitised states ' , British Journal of Pharmacology , vol. 180 , no. 19 , pp. 2482-2499 . https://doi.org/10.1111/bph.16143Test

مصطلحات موضوعية: chemical analogues, electrophysiology, GABA, GABA receptor, human embryonic kidney cells, kinetic modelling, molecular dynamics simulations, organic chemistry, pregnenolone sulfate, recombinant expression, synthesis

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1111/bph.16143Test
https://curis.ku.dk/portal/da/publications/pregnenolone-sulfate-analogues-differentially-modulate-gabaa-receptor-closeddesensitised-statesTest(69c62cd5-1789-4fe3-a6c5-82cb374f32e6).html
https://curis.ku.dk/ws/files/367836977/British_J_Pharmacology_2023_Mortensen.pdfTest

المؤلفون: Petersen, Jonas, Ludwig, Mette Q., Juozaityte, Vaida, Ranea-Robles, Pablo, Svendsen, Charlotte, Hwang, Eunsang, Kristensen, Amalie W., Fadahunsi, Nicole, Lund, Jens, Breum, Alberte W., Mathiesen, Cecilie V., Sachs, Luisa, Moreno-Justicia, Roger, Rohlfs, Rebecca, Ford, James C., Douros, Jonathan D., Finan, Brian, Portillo, Bryan, Grose, Kyle, Petersen, Jacob E., Trauelsen, Mette, Feuchtinger, Annette, DiMarchi, Richard D., Schwartz, Thue W., Deshmukh, Atul S., Thomsen, Morten B., Kohlmeier, Kristi A., Williams, Kevin W., Pers, Tune H., Frølund, Bente, Strømgaard, Kristian, Klein, Anders B., Clemmensen, Christoffer

المصدر: Nature; May 2024, Vol. 629 Issue: 8014 p1133-1141, 9p

المؤلفون: Griem-Krey, Nane, Gauger, Stine J., Gowing, Emma K., Thiesen, Louise, Frølund, Bente, Clarkson, Andrew N., Wellendorph, Petrine

المصدر: Griem-Krey , N , Gauger , S J , Gowing , E K , Thiesen , L , Frølund , B , Clarkson , A N & Wellendorph , P 2022 , ' The CaMKIIα hub ligand Ph-HTBA promotes neuroprotection after focal ischemic stroke by a distinct molecular interaction ' , Biomedicine and Pharmacotherapy , vol. 156 , 113895 . https://doi.org/10.1016/j.biopha.2022.113895Test

مصطلحات موضوعية: Autophosphorylation, Baclofen (PubChem CID: 44602), KN93 (PubChem CID: 5312122), CaMKII, GHB (PubChem CID: 23663870), HOCPCA (PubChem CID: 21750168), Hub domain, Motor behavior, Photothrombotic stroke

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1016/j.biopha.2022.113895Test
https://curis.ku.dk/portal/da/publications/the-camkii-hub-ligand-phhtba-promotes-neuroprotection-after-focal-ischemic-stroke-by-a-distinct-molecular-interactionTest(3ee80d1d-a021-4021-a788-305209948489).html
https://curis.ku.dk/ws/files/323978490/1_s2.0_S0753332222012847_main.pdfTest

المؤلفون: Kickinger, Stefanie, Lie, Maria E.K., Suemasa, Akihiro, Al-Khawaja, Anas, Fujiwara, Koichi, Watanabe, Mizuki, Wilhelmsen, Kristine S., Falk-Petersen, Christina B., Frølund, Bente, Shuto, Satoshi, Ecker, Gerhard F., Wellendorph, Petrine

المصدر: Kickinger , S , Lie , M E K , Suemasa , A , Al-Khawaja , A , Fujiwara , K , Watanabe , M , Wilhelmsen , K S , Falk-Petersen , C B , Frølund , B , Shuto , S , Ecker , G F & Wellendorph , P 2021 , ' Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT1 ' , Frontiers in Chemistry , vol. 9 , 736457 . https://doi.org/10.3389/fchem.2021.736457Test

مصطلحات موضوعية: BGT1, bicyclo-GABA, binding mode analysis, competitive inhibition, computational chemistry, GABA transporter, molecular docking, molecular dynamics, SLC6 neurotransmitter transporters

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.3389/fchem.2021.736457Test
https://curis.ku.dk/portal/da/publications/molecular-determinants-and-pharmacological-analysis-for-a-class-of-competitive-nontransported-bicyclic-inhibitors-of-the-betainegaba-transporter-bgt1Test(3c1da4ed-3d83-4788-9076-097464fac337).html
https://curis.ku.dk/ws/files/286502859/fchem_09_736457.pdfTest

المؤلفون: Falk-Petersen, Christina B, Rostrup, Frederik, Löffler, Rebekka, Buchleihtner, Stine, Harpsøe, Kasper, Gloriam, David E, Frølund, Bente, Wellendorph, Petrine

المصدر: Falk-Petersen , C B , Rostrup , F , Löffler , R , Buchleihtner , S , Harpsøe , K , Gloriam , D E , Frølund , B & Wellendorph , P 2021 , ' Molecular Determinants underlying Delta Selective Compound 2 (DS2) Activity at δ-Containing GABAA Receptors ' , Molecular Pharmacology , vol. 100 , no. 1 , pp. 46-56 . https://doi.org/10.1124/molpharm.121.000266Test

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1124/molpharm.121.000266Test
https://curis.ku.dk/portal/da/publications/molecular-determinants-underlying-delta-selective-compound-2-ds2-activity-at-containing-gabaa-receptorsTest(ac8d76d5-3e91-4e05-8858-5aced5be502f).html
https://curis.ku.dk/ws/files/277682985/molpharm.121.000266.full.pdfTest

المؤلفون: Dalby, Nils Ole, Falk-Petersen, Christina Birkedahl, Leurs, Ulrike, Scholze, Petra, Krall, Jacob, Frølund, Bente, Wellendorph, Petrine

المصدر: Dalby , N O , Falk-Petersen , C B , Leurs , U , Scholze , P , Krall , J , Frølund , B & Wellendorph , P 2020 , ' Silencing of spontaneous activity at α4β1/3δ GABAA receptors in hippocampal granule cells reveals different ligand pharmacology ' , British Journal of Pharmacology , vol. 177 , no. 17 , pp. 3975-3990 . https://doi.org/10.1111/bph.15146Test

الإتاحة: https://doi.org/10.1111/bph.15146Test
https://curis.ku.dk/portal/da/publications/silencing-of-spontaneous-activity-at-413-gabaa-receptors-in-hippocampal-granule-cells-reveals-different-ligand-pharmacologyTest(fc4414d4-5aac-4dd0-a06b-d1ab6a6abadf).html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429488/pdf/BPH-177-3975.pdfTest

المؤلفون: Falk-Petersen, Christina Birkedahl, Tsonkov, Tsonko M., Nielsen, Malene Sofie, Harpsøe, Kasper, Bundgaard, Christoffer, Frølund, Bente, Kristiansen, Uffe, Gloriam, David E., Wellendorph, Petrine

المصدر: Falk-Petersen , C B , Tsonkov , T M , Nielsen , M S , Harpsøe , K , Bundgaard , C , Frølund , B , Kristiansen , U , Gloriam , D E & Wellendorph , P 2020 , ' Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA A receptors ' , Scientific Reports , vol. 10 , no. 1 , 10078 . https://doi.org/10.1038/s41598-020-66821-0Test

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1038/s41598-020-66821-0Test
https://curis.ku.dk/portal/da/publications/discovery-of-a-new-class-of-orthosteric-antagonists-with-nanomolar-potency-at-extrasynaptic-gabaa-receptorsTest(63860d8b-7094-49d2-972c-fd2f0cb4a36b).html
https://curis.ku.dk/ws/files/247546698/s41598_020_66821_0.pdfTest