التفاصيل البيبلوغرافية
| العنوان: |
Frequency of Kell and Rh alloantibodies in Iranian Thalassemia Patients in Khorasan Razavi Province, Iran. |
| المؤلفون: |
Foomani, Farzad Mollahoseini1 shams8869@gmail.com, Sadeghian, Mohammad Hadi2, Bagheri, Saeede3, Badiee, Zahra4, Bazargani, Reihane1, Aryanpour, Zahra1, Hallajiayan, Saeid1, Shams, Seyyede Fatemeh3 |
| المصدر: |
International Journal of Hematology-Oncology & Stem Cell Research. Jan2023, Vol. 17 Issue 1, p4-8. 5p. |
| مصطلحات موضوعية: |
*BLOOD group antigens, *ABO blood group system, *BLOOD transfusion reaction, *BLOOD groups, *GENETIC disorders, *BLOOD transfusion |
| مصطلحات جغرافية: |
IRAN |
| مستخلص: |
Background: Thalassemia is an inherited disease with anemia and hemolysis. Blood transfusion is a routine treatment for thalassemia patients; alloimmunization is one of the complications of blood transfusion, which is very serious for these patients, especially girls and young women. Materials and Methods: In this cross-sectional study 446 thalassemia patients were examined. Demographic information of patients was extracted and recorded. The phenotype of ABO, Rh and Kell antigens (tube method) with antisera from IMMUNDIANOSTICA Company (Germany) and frequency of alloantibodies was determined. Results: 55.8% of studied individuals were male and 44.2% were female. Mean age of studied patients was 19.94±10.63. The alloantibodies were detected in 7.5% of pack cell receivers. The most prevalent phenotype of ABO system was O blood group (37.4%), and the most abundant antigen of Rh group was 'e', which was found in 99.8% of studied population. The most frequent detected alloantibody was Anti K (38.2%); concerning kell phenotype, (K_k+) and (K+k+) were found in 99.3% and 0.7% of patients, respectively. The frequency of Anti-D, Anti-C, Anti-c and Anti-E was 23.5%, 14.7%, 2.9% and 14.7%, respectively. Conclusion: According to the results of this paper, finding the compatible pack cells in terms of Kell and Rh systems antigens in addition to ABO blood group is recommended to decrease the rate of alloantibodies in thalassemia patients. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder