دورية أكاديمية
On the role of bacterial metalloproteases in COVID-19 associated cytokine storm
| العنوان: | On the role of bacterial metalloproteases in COVID-19 associated cytokine storm |
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| المؤلفون: | Foldvari-Nagy, L, Schnabel, T, Dornyei, G, Korcsmaros, T, Lenti, K |
| المصدر: | 7 ; 1 |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2020 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Cell Biology, IL-6, Cytokine storm, Metalloprotease, Bacteria, COVID-19, SOLUBLE INTERLEUKIN-6 RECEPTOR, STAPHYLOCOCCUS-AUREUS, VIRUS-INFECTION, IL-6 PRODUCTION, ACTIVATION, EXPRESSION, MECHANISM, GENE, TOCILIZUMAB, INDUCTION, Bacterial Proteins, Cytokine Release Syndrome, Humans, Interleukin-6, Metalloproteases, Receptors, SARS-CoV-2, Signal Transduction |
| الوصف: | The cytokine release syndrome or cytokine storm, which is the hyper-induction of inflammatory responses has a central role in the mortality rate of COVID-19 and some other viral infections. Interleukin-6 (IL-6) is a key player in the development of cytokine storms. Shedding of interleukin-6 receptor (IL-6Rα) results in the accumulation of soluble interleukin-6 receptors (sIL-6R). Only relatively few cells express membrane-bound IL-6Rα. However, sIL-6R can act on potentially all cells and organs through the ubiquitously expressed gp130, the coreceptor of IL-6Rα. Through this, so-called trans-signaling, IL-6–sIL-6R is a powerful factor in the development of cytokine storms and multiorgan involvement. Some bacteria (e.g., Serratia marcescens, Staphylococcus aureus, Pseudomonas aeruginosa, Listeria monocytogenes), commonly considered to cause co-infections during viral pneumonia, can directly induce the shedding of membrane receptors, including IL-6Rα, or enhance endogenous shedding mechanisms causing the increase of sIL-6R level. Here we hypothesise that bacteria promoting shedding and increase the sIL-6R level can be an important contributing factor for the development of cytokine storms. Therefore, inhibition of IL-6Rα shedding by drastically reducing the number of relevant bacteria may be a critical element in reducing the chance of a cytokine storm. Validation of this hypothesis can support the consideration of the prophylactic use of antibiotics more widely and at an earlier stage of infection to decrease the mortality rate of COVID-19. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1478-811X |
| العلاقة: | Cell Communication and Signaling; http://hdl.handle.net/10044/1/94350Test |
| DOI: | 10.1186/s12964-020-00699-3 |
| الإتاحة: | https://doi.org/10.1186/s12964-020-00699-3Test http://hdl.handle.net/10044/1/94350Test |
| حقوق: | © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0Test/. The Creative Commons Public Domain Dedication waiver (http://creativecoTest mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.E4D3F94C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1478811X |
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| DOI: | 10.1186/s12964-020-00699-3 |