المؤلفون: Holt, Amy K., Najumudeen, Arafath K., Collard, Tracey J., Li, Hao, Millett, Laura M., Hoskin, Ashley J., Legge, Danny N., Mortensson, Eleanor M. H., Flanagan, Dustin J., Jones, Nicholas, Kollareddy, Madhu, Timms, Penny, Hitchings, Matthew D., Cronin, James, Sansom, Owen J., Williams, Ann C., Vincent, Emma E.

المساهمون: Institute of Biotechnology, Kidney development, Helsinki Institute of Life Science HiLIFE

مصطلحات موضوعية: Aspirin, Cb-839, Colorectal cancer, Glutaminase, Metabolic reprogramming, Metabolism, 1182 Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: AKH and AJH were supported by the James Tudor Foundation; AKH, AJH and EMHM were supported by John and Bridget Maynard; and PT was supported by a PhD studentship from Bowel & Cancer Research. AKH, AJH, EMHM and PT were also supported by the John James Bristol Foundation. DF, TJC, OJS and ACW by an MRC Research Grant (MR/R017247/1). EEV and DNL are supported by Diabetes UK (17/0005587) and the World Cancer Research Fund (WCRF UK), as part of the World Cancer Research Fund International grant programme (IIG_2019_2009). EEV and TJC are supported by the Cancer Research UK (CRUK) Integrative Cancer Epidemiology Programme (C18281/A29019). AKN was supported by Cancer Research UK (CRUK) Beatson Institute core funding (A17196, A31287)-awarded to OJS. OJS was supported by CRUK grants (A21139, A12481, A17196 and A31287) and ERC Starting grant (311301). LMM is supported by a CRUK Scotland Centre Grant (CTRQQR-2021\100006).; Holt , A K , Najumudeen , A K , Collard , T J , Li , H , Millett , L M , Hoskin , A J , Legge , D N , Mortensson , E M H , Flanagan , D J , Jones , N , Kollareddy , M , Timms , P , Hitchings , M D , Cronin , J , Sansom , O J , Williams , A C & Vincent , E E 2023 , ' Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition ' , Cancer & Metabolism , vol. 11 , 18 . https://doi.org/10.1186/s40170-023-00318-yTest; 79183b88-6bce-46f8-be9f-33f80fb83f77; http://hdl.handle.net/10138/568723Test; 001097431700001

الإتاحة: http://hdl.handle.net/10138/568723Test

المؤلفون: Azkanaz, Maria, Corominas-Murtra, Bernat, Ellenbroek, Saskia I. J., Bruens, Lotte, Webb, Anna T., Laskaris, Dimitrios, Oost, Koen C., Lafirenze, Simona J. A., Annusver, Karl, Messal, Hendrik A., Iqbal, Sharif, Flanagan, Dustin J., Huels, David J., Rojas-Rodriguez, Felipe, Vizoso, Miguel, Kasper, Maria, Sansom, Owen J., Snippert, Hugo J., Liberali, Prisca, Simons, Benjamin D., Katajisto, Pekka, Hannezo, Edouard, van Rheenen, Jacco

المساهمون: Helsinki Institute of Life Science HiLIFE, Centre of Excellence in Stem Cell Metabolism, Institute of Biotechnology, Molecular and Integrative Biosciences Research Programme, University of Helsinki

مصطلحات موضوعية: IN-VIVO, COMPETITION, GENERATION, PLATFORM, PATTERN, MARKER, 1182 Biochemistry, cell and molecular biology, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: We thank the members of the van Rheenen laboratory for reading the manuscript, and the members of the bioimaging, FACS and animal facility of the NKI for experimental support. We acknowledge the staff at the MedH Flow Cytometry core facility, Karolinska Institutet, and LCI facility/Nikon Center of Excellence, Karolinska Institutet. This work was financially supported by the Netherlands Organization of Scientific Research NWO (Veni grant 863.15.011 to S.I.J.E. and Vici grant 09150182110004 to J.v.R.) and the CancerGenomics.nl (Netherlands Organisation for Scientific Research) program (to J.v.R.) the Doctor Josef Steiner Foundation (to J.v.R). B.D.S. acknowledges funding from the Royal Society E.P. Abraham Research Professorship (RP\R1\180165) and the Wellcome Trust (098357/Z/12/Z and 219478/Z/19/Z). B.C.-M. acknowledges the support of the field of excellence `Complexity of life in basic research and innovation' of the University of Graz. O.J.S. and their laboratory acknowledge CRUK core funding to the CRUK Beatson Institute (A17196 and A31287) and CRUK core funding to the Sansom laboratory (A21139). P.K. and their laboratory are supported by grants from the Swedish Research Council (2018-03078), Cancerfonden (190634), Academy of Finland Centre of Excellence (266869, 304591 and 320185) and the Jane and Aatos Erkko Foundation. P.L. has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 758617). E.H. acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 851288).; Azkanaz , M , Corominas-Murtra , B , Ellenbroek , S I J , Bruens , L , Webb , A T , Laskaris , D , Oost , K C , Lafirenze , S J A , Annusver , K , Messal , H A , Iqbal , S , Flanagan , D J , Huels , D J , Rojas-Rodriguez , F , Vizoso , M , Kasper , M , Sansom , O J , Snippert , H J , Liberali , P , Simons , B D , Katajisto , P , Hannezo , E & van Rheenen , J 2022 , ' Retrograde movements determine effective stem cell numbers in the intestine ' , Nature , vol. 607 , no. 7919 , pp. 548-+ . https://doi.org/10.1038/s41586-022-04962-0Test; 844f1b03-67b0-41f6-9d6a-84d7cebda907; http://hdl.handle.net/10138/355501Test; 000824430000004

الإتاحة: http://hdl.handle.net/10138/355501Test

المؤلفون: Flanagan, Dustin J, Amirkhah, Raheleh, Vincent, David F, Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J, McCorry, Amy M B, Fisher, Natalie C, Davis, Hayley L, Ridgway, Rachel A, Lohuis, Jeroen, Leach, Joshua D G, Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K, Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L, Kerr, Emma M, Longley, Daniel B, Ginty, Fiona, Cho, Sanghee, Coleman, Helen G, Loughrey, Maurice B, Bardelli, Alberto, Maughan, Timothy S, Campbell, Andrew D, Lawler, Mark, Leedham, Simon J, Barry, Simon T, Inman, Gareth J, van Rheenen, Jacco, Dunne, Philip D, Sansom, Owen J

المصدر: Flanagan , D J , Amirkhah , R , Vincent , D F , Gunduz , N , Gentaz , P , Cammareri , P , McCooey , A J , McCorry , A M B , Fisher , N C , Davis , H L , Ridgway , R A , Lohuis , J , Leach , J D G , Jackstadt , R , Gilroy , K , Mariella , E , Nixon , C , Clark , W , Hedley , A , Markert , E K , Strathdee , D , Bartholin , L , ....

الإتاحة: https://doi.org/10.1038/s41467-023-36266-wTest
https://pure.qub.ac.uk/en/publications/eb4cecdd-957d-49df-922a-f34920a05c4fTest

المؤلفون: Lim, Chuan K., Romeo, Ornella, Tran, Bang M., Flanagan, Dustin J., Kirby, Emily N., McCartney, Erin M., Tse, Edmund, Vincan, Elizabeth, Beard, Michael R.

المصدر: Journal of Medical Virology ; volume 95, issue 11 ; ISSN 0146-6615 1096-9071

الإتاحة: https://doi.org/10.1002/jmv.29232Test

المؤلفون: van Driel, Milou S., Linssen, Jasmijn D.G., Flanagan, Dustin J., Vlahov, Nikola, Nijman, Lisanne E., de Groot, Nina E., Elbers, Clara C., Koster, Jan, Sansom, Owen J., Vermeulen, Louis, van Neerven, Sanne M.

المصدر: Cellular and Molecular Gastroenterology and Hepatology ; volume 16, issue 4, page 652-655 ; ISSN 2352-345X

مصطلحات موضوعية: Gastroenterology, Hepatology

الإتاحة: https://doi.org/10.1016Test/j.jcmgh.2023.06.008
https://api.elsevier.com/content/article/PII:S2352345X23001236?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2352345X23001236?httpAccept=text/plainTest

المؤلفون: Vasquez, Ester Gil, Nasreddin, Nadia, Valbuena, Gabriel N, Mulholland, Eoghan J, Belnoue-Davis, Hayley L, Eggington, Holly R, Schenck, Ryan O, Wouters, Valérie M, Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R M, Flanagan, Dustin J, Najumudeen, Arafath K, Omwenga, Sulochana, McCorry, Amy M B, Easton, Alistair, Koelzer, Viktor H, East, James E, Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D, Loughrey, Maurice B, Dunne, Philip D, Tsantoulis, Petros, Huels, David J, Tejpar, Sabine, Sansom, Owen J, Leedham, Simon J

المساهمون: Vasquez, Ester Gil, Nasreddin, Nadia, Valbuena, Gabriel N, Mulholland, Eoghan J, Belnoue-Davis, Hayley L, Eggington, Holly R, Schenck, Ryan O, Wouters, Valérie M, Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R M, Flanagan, Dustin J, Najumudeen, Arafath K, Omwenga, Sulochana, McCorry, Amy M B, Easton, Alistair, Koelzer, Viktor H, East, James E, Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D, Loughrey, Maurice B, Dunne, Philip D, Tsantoulis, Petro, Huels, David J, Tejpar, Sabine, Sansom, Owen J, Leedham, Simon J

مصطلحات موضوعية: cell plasticity, colorectal cancer, colorectal neoplasia, intestinal polyp, intestinal stem cell, molecular phenotyping, stem cell, Animal, Homeostasi, Human, Intestine, Mice, Neoplastic Stem Cell, Receptors, G-Protein-Coupled, Colorectal Neoplasm, Intestinal Mucosa

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35931031; info:eu-repo/semantics/altIdentifier/wos/WOS:000843892000007; volume:29; issue:8; firstpage:1213; lastpage:1228; numberofpages:16; journal:CELL STEM CELL; https://hdl.handle.net/2318/1880629Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85135464912

الإتاحة: https://doi.org/10.1016Test/j.stem.2022.07.008
https://hdl.handle.net/2318/1880629Test

المؤلفون: Flanagan, Dustin J, Amirkhah, Raheleh, Vincent, David F, Gundaz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J, McCorry, Amy M B, Fisher, Natalie C, Davis, Hayley L, Ridgway, Rachel A, Lohuis, Jeroen, Leach, Joshua D G, Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K, Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L, Kerr, Emma M, Longley, Daniel B, Ginty, Fiona, Cho, Sanghee, Coleman, Helen G, Loughrey, Maurice B, Bardelli, Alberto, Maughan, Timothy S, Campbell, Andrew D, Lawler, Mark, Leedham, Simon J, Barry, Simon T, Inman, Gareth J, van Rheenen, Jacco, Dunne, Philip D, Sansom, Owen J

المساهمون: Flanagan, Dustin J, Amirkhah, Raheleh, Vincent, David F, Gundaz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J, McCorry, Amy M B, Fisher, Natalie C, Davis, Hayley L, Ridgway, Rachel A, Lohuis, Jeroen, Leach, Joshua D G, Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K, Strathdee, Dougla, Bartholin, Laurent, Redmond, Keara L, Kerr, Emma M, Longley, Daniel B, Ginty, Fiona, Cho, Sanghee, Coleman, Helen G, Loughrey, Maurice B, Bardelli, Alberto, Maughan, Timothy S, Campbell, Andrew D, Lawler, Mark, Leedham, Simon J, Barry, Simon T, Inman, Gareth J, van Rheenen, Jacco, Dunne, Philip D, Sansom, Owen J

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36477656; volume:13; issue:1; firstpage:7551; lastpage:-; numberofpages:18; journal:NATURE COMMUNICATIONS; https://hdl.handle.net/2318/1888614Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85143536191; https://www.nature.com/articles/s41467-022-35134-3Test

الإتاحة: https://doi.org/10.1038/s41467-022-35134-3Test
https://hdl.handle.net/2318/1888614Test
https://www.nature.com/articles/s41467-022-35134-3Test

المؤلفون: Parker, Christopher, Chambers, Adam C, Flanagan, Dustin J, Ho, Jasmine Wing Yu, Collard, Tracey J, Ngo, Greg, Baird, Duncan M, Timms, Penny, Morgan, Rhys G, Sansom, Owen J, Williams, Ann C

وصف الملف: application/pdf

العلاقة: http://sro.sussex.ac.uk/id/eprint/105552/1/1-s2.0-S1568786422000647-main.pdfTest; Parker, Christopher, Chambers, Adam C, Flanagan, Dustin J, Ho, Jasmine Wing Yu, Collard, Tracey J, Ngo, Greg, Baird, Duncan M, Timms, Penny, Morgan, Rhys G, Sansom, Owen J and Williams, Ann C (2022) BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination. DNA Repair, 115. a103331 1-11. ISSN 1568-7864

الإتاحة: https://doi.org/10.1016Test/j.dnarep.2022.103331
http://sro.sussex.ac.uk/id/eprint/105552Test/
http://sro.sussex.ac.uk/id/eprint/105552/1/1-s2.0-S1568786422000647-main.pdfTest

المؤلفون: Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gundaz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D.G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., Sansom, Owen J.

وصف الملف: text

العلاقة: https://eprints.gla.ac.uk/287245/1/287245.pdfTest; Flanagan, D. J. et al. (2022) Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features. Nature Communications , 13, 7551. (doi:10.1038/s41467-022-35134-3 ) (PMID:36477656) (PMCID:PMC9729215)

الإتاحة: https://doi.org/10.1038/s41467-022-35134-3Test
https://eprints.gla.ac.uk/287245Test/
https://eprints.gla.ac.uk/287245/1/287245.pdfTest

المؤلفون: Flanagan, Dustin J., Woodcock, Simon A., Phillips, Caroline, Eagle, Catherine, Sansom, Owen J.

وصف الملف: text

العلاقة: http://eprints.gla.ac.uk/269180/1/269180.pdfTest; Flanagan, D. J. , Woodcock, S. A., Phillips, C., Eagle, C. and Sansom, O. J. (2022) Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition. Pharmacology and Therapeutics , 238, 108179. (doi:10.1016/j.pharmthera.2022.108179 ) (PMID:35358569)

الإتاحة: https://doi.org/10.1016Test/j.pharmthera.2022.108179
http://eprints.gla.ac.uk/269180Test/
http://eprints.gla.ac.uk/269180/1/269180.pdfTest