المؤلفون: Gahbauer, Stefan, DeLeon, Chelsea, Braz, Joao, Craik, Veronica, Kang, Hye, Wan, Xiaobo, Huang, Xi-Ping, Billesbølle, Christian, Liu, Yongfeng, Che, Tao, Deshpande, Ishan, Fink, Elissa, Kondratov, Ivan, Moroz, Yurii, Roth, Bryan, Basbaum, Allan, Shoichet, Brian, Jewell, Madison, Irwin, John

المصدر: Nature Communications. 14(1)

مصطلحات موضوعية: Humans, Mice, Animals, Dinoprostone, Receptors, Prostaglandin, Phagocytosis, Anti-Inflammatory Agents, Pain, Anti-Inflammatory Agents, Non-Steroidal

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4xz106d7Test

المؤلفون: Fink, Elissa A, Bardine, Conner, Gahbauer, Stefan, Singh, Isha, Detomasi, Tyler C, White, Kris, Gu, Shuo, Wan, Xiaobo, Chen, Jun, Ary, Beatrice, Glenn, Isabella, O'Connell, Joseph, O'Donnell, Henry, Fajtová, Pavla, Lyu, Jiankun, Vigneron, Seth, Young, Nicholas J, Kondratov, Ivan S, Alisoltani, Arghavan, Simons, Lacy M, Lorenzo‐Redondo, Ramon, Ozer, Egon A, Hultquist, Judd F, O'Donoghue, Anthony J, Moroz, Yurii S, Taunton, Jack, Renslo, Adam R, Irwin, John J, García‐Sastre, Adolfo, Shoichet, Brian K, Craik, Charles S

المصدر: Protein Science. 32(8)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Lung, Prevention, Emerging Infectious Diseases, Infectious Diseases, Vaccine Related, Biodefense, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, Humans, COVID-19, SARS-CoV-2, Pandemics, Protease Inhibitors, Molecular Docking Simulation, Viral Nonstructural Proteins, Antiviral Agents, major protease, SARS-COV-2, structure-based inhibitor, discoverydockinganti-viral, Biochemistry and Cell Biology, Computation Theory and Mathematics, Other Information and Computing Sciences, Biophysics, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/61h336z6Test

المؤلفون: Singh, Isha, Li, Fengling, Fink, Elissa A, Chau, Irene, Li, Alice, Rodriguez-Hernández, Annía, Glenn, Isabella, Zapatero-Belinchón, Francisco J, Rodriguez, M Luis, Devkota, Kanchan, Deng, Zhijie, White, Kris, Wan, Xiaobo, Tolmachova, Nataliya A, Moroz, Yurii S, Kaniskan, H Ümit, Ott, Melanie, García-Sastre, Adolfo, Jin, Jian, Fujimori, Danica Galonić, Irwin, John J, Vedadi, Masoud, Shoichet, Brian K

المصدر: Journal of Medicinal Chemistry. 66(12)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Emerging Infectious Diseases, Infectious Diseases, Humans, Methyltransferases, SARS-CoV-2, Viral Nonstructural Proteins, COVID-19, RNA, Viral, Exoribonucleases, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, Pharmacology and pharmaceutical sciences, Medicinal and biomolecular chemistry, Organic chemistry

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9th7x7gcTest
https://escholarship.org/content/qt9th7x7gc/qt9th7x7gc.pdfTest

المؤلفون: Fink, Elissa A, Xu, Jun, Hübner, Harald, Braz, Joao M, Seemann, Philipp, Avet, Charlotte, Craik, Veronica, Weikert, Dorothee, Schmidt, Maximilian F, Webb, Chase M, Tolmachova, Nataliya A, Moroz, Yurii S, Huang, Xi-Ping, Kalyanaraman, Chakrapani, Gahbauer, Stefan, Chen, Geng, Liu, Zheng, Jacobson, Matthew P, Irwin, John J, Bouvier, Michel, Du, Yang, Shoichet, Brian K, Basbaum, Allan I, Gmeiner, Peter

المصدر: Science. 377(6614)

مصطلحات موضوعية: Adrenergic alpha-2 Receptor Agonists, Analgesics, Non-Narcotic, Animals, Dexmedetomidine, Drug Design, Drug Discovery, Humans, Ligands, Mice, Molecular Docking Simulation, Pain, Pain Management, Structure-Activity Relationship, Neurosciences, Pain Research, Chronic Pain, General Science & Technology

الوصول الحر: https://escholarship.org/uc/item/6r0990sdTest

المؤلفون: Bender, Brian J, Gahbauer, Stefan, Luttens, Andreas, Lyu, Jiankun, Webb, Chase M, Stein, Reed M, Fink, Elissa A, Balius, Trent E, Carlsson, Jens, Irwin, John J, Shoichet, Brian K

المصدر: Nature Protocols. 16(10)

مصطلحات موضوعية: Brain Disorders, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Drug Design, Ligands, Molecular Docking Simulation, Software, Chemical Sciences, Biological Sciences, Medical and Health Sciences, Bioinformatics

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9hs932s0Test

المؤلفون: Newberry, Robert W, Arhar, Taylor, Costello, Jean, Hartoularos, George C, Maxwell, Alison M, Naing, Zun Zar Chi, Pittman, Maureen, Reddy, Nishith R, Schwarz, Daniel MC, Wassarman, Douglas R, Wu, Taia S, Barrero, Daniel, Caggiano, Christa, Catching, Adam, Cavazos, Taylor B, Estes, Laurel S, Faust, Bryan, Fink, Elissa A, Goldman, Miriam A, Gomez, Yessica K, Gordon, M Grace, Gunsalus, Laura M, Hoppe, Nick, Jaime-Garza, Maru, Johnson, Matthew C, Jones, Matthew G, Kung, Andrew F, Lopez, Kyle E, Lumpe, Jared, Martyn, Calla, McCarthy, Elizabeth E, Miller-Vedam, Lakshmi E, Navarro, Erik J, Palar, Aji, Pellegrino, Jenna, Saylor, Wren, Stephens, Christina A, Strickland, Jack, Torosyan, Hayarpi, Wankowicz, Stephanie A, Wong, Daniel R, Wong, Garrett, Redding, Sy, Chow, Eric D, DeGrado, William F, Kampmann, Martin

المصدر: ACS Chemical Biology. 15(8)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Brain Disorders, Genetics, Neurosciences, Neurodegenerative, Parkinson's Disease, 2.1 Biological and endogenous factors, Aetiology, Generic health relevance, Amino Acid Sequence, Humans, Mutation, Parkinson Disease, Protein Conformation, Saccharomyces cerevisiae, alpha-Synuclein, Chemical Sciences, Organic Chemistry, Biological sciences, Chemical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9k81784dTest

المؤلفون: Bender, Brian J., Gahbauer, Stefan, Luttens, Andreas, Lyu, Jiankun, Webb, Chase M., Stein, Reed M., Fink, Elissa A., Balius, Trent E., Carlsson, Jens, Irwin, John J., Shoichet, Brian K.

المصدر: Nature Protocols ; volume 17, issue 1, page 177-177 ; ISSN 1754-2189 1750-2799

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology

الإتاحة: https://doi.org/10.1038/s41596-021-00650-xTest
https://www.nature.com/articles/s41596-021-00650-x.pdfTest
https://www.nature.com/articles/s41596-021-00650-xTest

المؤلفون: Fink, Elissa A., Xu, Jun, Hübner, Harald, Braz, Joao M., Seemann, Philipp, Avet, Charlotte, Craik, Veronica, Weikert, Dorothee, Schmidt, Maximilian F., Webb, Chase M., Tolmachova, Nataliya A., Moroz, Yurii S., Huang, Xi-Ping, Kalyanaraman, Chakrapani, Gahbauer, Stefan, Chen, Geng, Liu, Zheng, Jacobson, Matthew P., Irwin, John J., Bouvier, Michel, Du, Yang, Shoichet, Brian K., Basbaum, Allan I., Gmeiner, Peter

المصدر: Science ; volume 377, issue 6614 ; ISSN 0036-8075 1095-9203

الإتاحة: https://doi.org/10.1126/science.abn7065Test

المؤلفون: Fink, Elissa

المساهمون: Shoichet, Brian K

مصطلحات موضوعية: Biophysics, Biology, Chemistry, molecular docking, MPro, Nsp14, pain, polypharmacology, α2A adrenergic receptor

وصف الملف: application/pdf

العلاقة: qt41n618z3; https://escholarship.org/uc/item/41n618z3Test; https://escholarship.org/content/qt41n618z3/qt41n618z3.pdfTest

الإتاحة: https://escholarship.org/uc/item/41n618z3Test
https://escholarship.org/content/qt41n618z3/qt41n618z3.pdfTest

المؤلفون: Zang, Xiaoyu, Peraro, Leila, Davison, Ryan T., Blum, Travis R., Vallabhaneni, Deepak, Fennell, Caitlyn E., Cramer, Stephanie L., Shah, Heli K., Wholly, Deirdre M., Fink, Elissa A., Sivak, Jacob T., Ingalls, Kathryn M., Herr, Chelsea T., Lawson, Vernon E., Burnett, Matthew R., Slade, David J., Cole, Kathryn E., Carle, Sigrid A., Miller, Justin S.

المساهمون: U.S. Department of Health and Human Services, National Science Foundation, Virginia Academy of Science, Camille and Henry Dreyfus Foundation, Virginia's Commonwealth Health Research Board, Research Corp

المصدر: The Journal of Organic Chemistry ; volume 85, issue 12, page 8253-8260 ; ISSN 0022-3263 1520-6904

مصطلحات موضوعية: Organic Chemistry

الإتاحة: https://doi.org/10.1021/acs.joc.0c00854Test