المؤلفون: Yli-Öyrä, Johanna, Juvonen, Risto, Lehtonen, Marko, Herrala, Mikko, Finel, Moshe, Räisänen, Riikka, Rysä, Jaana

المساهمون: Divisions of Faculty of Pharmacy, Pharmaceutical Design and Discovery group, Drug Research Program, Medicum, Moshe Finel / Principal Investigator, Department of Education

مصطلحات موضوعية: 116 Chemical sciences, 516 Educational sciences

وصف الملف: application/pdf

العلاقة: Yli-Öyrä , J , Juvonen , R , Lehtonen , M , Herrala , M , Finel , M , Räisänen , R & Rysä , J 2024 , ' Anthraquinone biocolourant dermocybin is metabolized whereas dermorubin is not in in vitro liver fractions and recombinant metabolic enzymes ' , Basic & Clinical Pharmacology & Toxicology . https://doi.org/10.1111/bcpt.14013Test; ORCID: /0000-0003-2918-3739/work/159034775; http://hdl.handle.net/10138/575090Test; bc49646a-0c0f-48cd-8dd8-f7947add16c9

الإتاحة: http://hdl.handle.net/10138/575090Test

المؤلفون: Yli‐Öyrä, Johanna, Juvonen, Risto O., Lehtonen, Marko, Herrala, Mikko, Finel, Moshe, Räisänen, Riikka, Rysä, Jaana

المساهمون: Research Council of Finland

المصدر: Basic & Clinical Pharmacology & Toxicology ; ISSN 1742-7835 1742-7843

الإتاحة: https://doi.org/10.1111/bcpt.14013Test

المؤلفون: Tu, Dong-Zhu, Liu, Pei-Qi, Zhu, Guang-Hao, Zeng, Hai-Rong, Deng, Yan-Yan, Huang, Jian, Niu, Xiao-Ting, Liu, Yan-Fang, Hu, Jing, Liang, Xin-Miao, Finel, Moshe, Wang, Ping, Ge, Guang-Bo

المساهمون: National Natural Science Foundation of China

المصدر: Journal of Ethnopharmacology ; volume 328, page 118116 ; ISSN 0378-8741

مصطلحات موضوعية: Drug Discovery, Pharmacology

الإتاحة: https://doi.org/10.1016/j.jep.2024.118116Test
https://api.elsevier.com/content/article/PII:S037887412400415X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S037887412400415X?httpAccept=text/plainTest

المؤلفون: Zhou, Qi-Hang, Qin, Wei-Wei, Finel, Moshe, He, Qing-Qing, Tu, Dong-Zhu, Wang, Chao-Ran, Ge, Guang-Bo

المساهمون: Divisions of Faculty of Pharmacy, Pharmaceutical Design and Discovery group, Drug Research Program, Moshe Finel / Principal Investigator, Division of Pharmaceutical Chemistry and Technology

مصطلحات موضوعية: Methylophiopogonanone A, UDP-glucuronosyltransferases (UGTs), Drug-drug interactions (DDI), HUMAN CYTOCHROME-P450 3A4, IN-VIVO, 1-NAPHTHOL GLUCURONIDATION, ISOFORM SELECTIVITY, N-GLUCURONIDATION, HUMAN-LIVER, DRUG, IDENTIFICATION, ENZYMES, METABOLISM, Chemical sciences, Biochemistry, cell and molecular biology, Pharmacy

وصف الملف: application/pdf

العلاقة: This work was supported by the NSF of China (81922070, 81773687), the National Key Research and Development Program of China (2017YFC1700200, 2017YFC1702000), the Three-year Action Plan of Shanghai TCM Development (ZY-(2018-2020)-CCCX-5001), Shanghai Talent Development Fund (2019093), Program of Shanghai Academic/Technology Research Leader (18XD1403600), Shanghai Science and Technology Innovation Action Plans (20S21901500 & 20S21900900) supported by Shanghai Science and Technology Committee, and Shuguang Program (18SG40) supported by Shanghai Education Development Foundation and ShanghaiMunicipal Education Commission.; Zhou , Q-H , Qin , W-W , Finel , M , He , Q-Q , Tu , D-Z , Wang , C-R & Ge , G-B 2021 , ' A broad-spectrum substrate for the human UDP-glucuronosyltransferases and its use for investigating glucuronidation inhibitors ' , International Journal of Biological Macromolecules , vol. 180 , pp. 252-261 . https://doi.org/10.1016/j.ijbiomac.2021.03.073Test; http://hdl.handle.net/10138/341746Test; 72757e1d-9911-42cb-bd26-f28e5b5f80c9; 000649643500009

الإتاحة: http://hdl.handle.net/10138/341746Test

المؤلفون: Jin, Qiang, Wu, JingJing, Wu, Yue, Li, Hongxin, Finel, Moshe, Wang, Dandan, Ge, Guangbo

المصدر: Acta Pharmaceutica Sinica B ; volume 12, issue 3, page 1068-1099 ; ISSN 2211-3835

مصطلحات موضوعية: General Pharmacology, Toxicology and Pharmaceutics

الإتاحة: https://doi.org/10.1016/j.apsb.2022.01.009Test
https://api.elsevier.com/content/article/PII:S2211383522000223?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2211383522000223?httpAccept=text/plainTest

المؤلفون: Skledar, Darja Gramec, Carino, Adriana, Trontelj, Jurij, Troberg, Johanna, Distrutti, Eleonora, Marchiano, Silvia, Tornasic, Tihomir, Zega, Anamarija, Finel, Moshe, Fiorucci, Stefano, Maisic, Lucija Peterlin

المساهمون: Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, Pharmaceutical Design and Discovery group, Drug Research Program, Moshe Finel / Principal Investigator

مصطلحات موضوعية: Bisphenol AF, Bisphenol AF glucuronide, Glucuronidation, Endocrine activities, Lipid accumulation, IN-VITRO, SEWAGE-SLUDGE, ANALOGS, CELLS, TOXICITY, GAMMA, IDENTIFICATION, PREADIPOCYTES, ANTAGONIST, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: The authors thank OpenEye Scientific Software, Santa Fe, NM, USA, for free academic licenses for the use of their software, and Johanna Mosorin for skillful assistance in recombinant UGT preparations. Financial support of the Slovenian Research Agency (Grant No. P1-0208) and the Sigrid Juseliuksen Saatio, Finland (grant no. 4704583) are acknowledged.; Skledar , D G , Carino , A , Trontelj , J , Troberg , J , Distrutti , E , Marchiano , S , Tornasic , T , Zega , A , Finel , M , Fiorucci , S & Maisic , L P 2019 , ' Endocrine activities and adipogenic effects of bisphenol AF and its main metabolite ' , Chemosphere , vol. 215 , pp. 870-880 . https://doi.org/10.1016/j.chemosphere.2018.10.129Test; ORCID: /0000-0003-3886-4771/work/51564915; http://hdl.handle.net/10138/325049Test; f063b300-8d14-4568-8375-b75ca2da9adc; 85055983814; 000450383400096

الإتاحة: http://hdl.handle.net/10138/325049Test

المؤلفون: Zhu, Ya-Di, Guan, Xiao-Qing, Chen, Jing, Peng, Sheng, Finel, Moshe, Zhao, Ying-Yuan, Wang, Rui-Min, Bi, Hui-Chang, Lei, Ming, Wang, Dan-Dan, Ge, Guang-Bo

المساهمون: Divisions of Faculty of Pharmacy, Pharmaceutical Design and Discovery group, Drug Research Program, Moshe Finel / Principal Investigator, Division of Pharmaceutical Chemistry and Technology

مصطلحات موضوعية: flavonoids, induction, peroxisome proliferator-activated receptors, neobavaisoflavone, 317 Pharmacy

وصف الملف: application/pdf

العلاقة: This work was financially supported by the Outstanding Clinical Discipline Project of Shanghai Pudong (PWYgy2018-01), the NSF of China (82073813, 81922070, 81703604, 81773687), the National Key Research and Development Program of China (2020YFC0845400, 2017YFC1700200, 2017YFC1702000), Program of Shanghai Academic/Technology Research Leader (18XD1403600), the Three-year Action Plan of Shanghai TCM Development (ZY-(2018-2020)-CCCX-5001), the National Science and Technology Major Project of China (2018ZX09731016), the Shanghai Talent Development Fund (2019093) and Shuguang Program (18SG40) supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission.; Zhu , Y-D , Guan , X-Q , Chen , J , Peng , S , Finel , M , Zhao , Y-Y , Wang , R-M , Bi , H-C , Lei , M , Wang , D-D & Ge , G-B 2021 , ' Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARα and PPARγ ' , Frontiers in Pharmacology , vol. 11 , 628314 . https://doi.org/10.3389/fphar.2020.628314Test; 40b676d4-d28e-45cf-8bc4-82a5c5567a20; http://hdl.handle.net/10138/328198Test; 000620032500001

الإتاحة: http://hdl.handle.net/10138/328198Test

المؤلفون: Stroh, Anke, Anderka, Oliver, Pfeiffer, Kathy, Yagi, Takao, Finel, Moshe, Ludwig, Bernd, Schägger, Hermann

مصطلحات موضوعية: ddc:570, ddc:610

وصف الملف: application/pdf

العلاقة: http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/76143Test; urn:nbn:de:hebis:30:3-761435; https://nbn-resolving.org/urn:nbn:de:hebis:30:3-761435Test; https://doi.org/10.1074/jbc.M309505200Test; http://publikationen.ub.uni-frankfurt.de/files/76143/1-s2.0-S0021925820750908-main.pdfTest

الإتاحة: https://doi.org/10.1074/jbc.M309505200Test
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/76143Test
https://nbn-resolving.org/urn:nbn:de:hebis:30:3-761435Test
http://publikationen.ub.uni-frankfurt.de/files/76143/1-s2.0-S0021925820750908-main.pdfTest

المؤلفون: Zhu, Ya-Di, Pang, Hui-Lin, Zhou, Qi-Hang, Qin, Zi-Fei, Jin, Qiang, Finel, Moshe, Wang, Yi-Nan, Qin, Wei-Wei, Lu, Yin, Wang, Dan-Dan, Ge, Guang-Bo

المساهمون: Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Pharmaceutical Design and Discovery group, Moshe Finel / Principal Investigator, University Management

مصطلحات موضوعية: UGT1A1, LC-FD, N-butyl-4-(4-hydroxyphenyl)-1,8-naphthalimide, Modulators, CHROMATOGRAPHY/TANDEM MASS-SPECTROMETRY, UDP-GLUCURONOSYLTRANSFERASE 1A1, FLUORESCENT-PROBE, HUMAN LIVER, GLUCURONIDATION, BILIRUBIN, INDUCTION, CHRYSIN, INHIBITION, MICROSOMES, Pharmacy

وصف الملف: application/pdf

العلاقة: This work was finically supported by the NSF of China (81773687, 81922070, 81973286, 81703604), the National Key Research and Development Program of China (2017YFC1700200, 2017YFC1702000), the Open Project Program of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica (No.JKLPSE-201803), the Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), Program of Shanghai Academic/Technology Research Leader (18XD1403600), Drug Innovation Major Project (2018ZX09731016), Shuguang Program (18SG40) supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission, and the Graduate Innovation Project of Shanghai University of Traditional Chinese Medicine (Y2019063).; Zhu , Y-D , Pang , H-L , Zhou , Q-H , Qin , Z-F , Jin , Q , Finel , M , Wang , Y-N , Qin , W-W , Lu , Y , Wang , D-D & Ge , G-B 2020 , ' An ultra-sensitive and easy-to-use assay for sensing human UGT1A1 activities in biological systems ' , Journal of Pharmaceutical Analysis , vol. 10 , no. 3 , pp. 263-270 . https://doi.org/10.1016/j.jpha.2020.05.005Test; http://hdl.handle.net/10138/317883Test; a7d68f50-1eb7-4778-b84d-cc24504ac72e; 000544131200009

الإتاحة: http://hdl.handle.net/10138/317883Test

المؤلفون: Järvinen, Erkka, Deng, Feng, Kidron, Heidi, Finel, Moshe

المساهمون: Pharmaceutical Design and Discovery group, Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, Division of Pharmaceutical Biosciences, Drug Research Program, Moshe Finel / Principal Investigator, Drug Delivery Unit

مصطلحات موضوعية: Drug transporters, Steroid disposition, Steroid transport, Estrogen, Glucuronides, Steroid excretion, MULTIDRUG-RESISTANCE PROTEIN-2, PHENOLIC STEROIDS, HUMAN FEMALE, HUMAN LIVER, 17-ALPHA-ETHINYLESTRADIOL ASSESSMENT, 3-O-SULFATE CONJUGATE, LIQUID-CHROMATOGRAPHY, METABOLISM, ESTRIOL, 1182 Biochemistry, cell and molecular biology, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: The funding from the University of Helsinki Doctoral Program in Drug Research, Sigrid Juselius Foundation (grant no. 4704583) and the Academy of Finland (grant no. 292779) is acknowledged.; Järvinen , E , Deng , F , Kidron , H & Finel , M 2018 , ' Efflux transport of estrogen glucuronides by human MRP2, MRP3, MRP4 and BCRP ' , Journal of Steroid Biochemistry and Molecular Biology , vol. 178 , pp. 99-107 . https://doi.org/10.1016/j.jsbmb.2017.11.007Test; RIS: urn:ED82590D26CEA9F871692D87FA306F02; ORCID: /0000-0001-6427-8042/work/43736667; ORCID: /0000-0001-8970-5194/work/43736799; ORCID: /0000-0002-9173-6923/work/106339712; 85042154617; bf7010de-b6f7-4285-a33a-a6d6d08826c7; http://hdl.handle.net/10138/321530Test; 000428483800012

الإتاحة: http://hdl.handle.net/10138/321530Test